Format:
Online-Ressource (XVI, 187 p. 35 illus., 34 illus. in color, digital)
ISBN:
9781461450825
Series Statement:
SpringerLink
Content:
Circadian rhythms are such an innate part of our lives that we rarely pause to speculate why they even exist. Perhaps this is the reason why in the medical practice the circadian variability of hormones, metabolites, physiological behaviors or the relevance of time in the presence or absence of different pathologies, have been practically ignored in the past. Some studies have suggested that the disruption of the circadian system may be cause for obesity and manifestations of Metabolic Syndrome (MetS). Shift-work, sleep-deprivation and bright-light-exposure at night are related to increased adiposity (obesity) and prevalence of MetS. Chronobiology and Obesity examines recent advances that have led to researchers to find the relevant link which exists between chronobiology and obesity, but, as it is emphasized throughout the book, there is much more that needs to be explored between the connection.
Note:
Description based upon print version of record
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Chronobiology and Obesity; A Historical Perspective; Preface; Contents; Contributors; Chapter 1: Discovery of the Clock Mutant and the First Mammalian Clock Gene and the Links to Obesity: Starting with Animal #25; The Importance of Mouse #25; Surprise: The Molecular Circadian Clock Is Everywhere; How #25 Led to New Links Between Circadian Clock and Obesity/Metabolic Regulatory Genes; Summary; References; Chapter 2: An Introduction to Chronobiology; Introduction: The Circadian System; Circadian Clocks; Input Pathways; Output Pathways; The Molecular Clock; Some Basic Issues in Chronobiology
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Monitoring the Functional Status of the Circadian SystemCentral and Peripheral Thermometry; Actimetry; Light Exposure; Integration of Variables; Melatonin; Cortisol; Expression of Clock Genes in Leukocytes and Oral Mucosa; Protocols for Measuring Circadian Rhythms; Analyses of Circadian Rhythm; Summary Points; References; Chapter 3: Adipose Tissue as a Peripheral Clock; Adipose Tissue as Endocrine Organ; Glucocorticoids: The Circadian Hormone; Brown and White Adipose Tissue: Adipocytes or Stromal-Vascular Cells?; Visceral and Subcutaneous, Two Different Adipose Tissues
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The "When" in the Adipose Tissue: A Peripheral ClockIntroduction; The Importance of "Time" in Metabolism of Adipose Tissue; Food Intake and Lipogenesis and Lipogenetic Processes; Circadian Rhythmicity in Adipokines; Adipocytes Differentiation and Adipogenesis; Other Key Nutrient Sensors; The Adipose Tissue: A Peripheral Clock; The Clock Control genes; Techniques in the Assessment of a Peripheral Clock in adipose tissue; A Map of Phases in Adipose Tissue; Timing Interconnections Among Different Adipokines; Causation; Differences Between Visceral and Subcutaneous AT; Conclusion; Summary Points
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ReferencesChapter 4: Processes Underlying Chronodisruption and Their Proposed Association with Illness; Introduction; What Causes Chronodisruption?; Inadequate Inputs; Importance of a Regular Light-Dark Cycle; Sleep Deprivation; Feeding Time; Impaired Pacemakers; Outputs; Pathological Consequences of CD; Chronodisruption and Cancer; Chronodisruption, Metabolic Syndrome (MetS), and Obesity; Other Pathologies Related to CD; Concluding Remarks; Summary Points; References; Chapter 5: Obesity and Chronodisruption: An Imbalance Between Energy Intake and Expenditure
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Introduction: Obesity and ChronodisruptionCircadian Rhythms in Metabolism; Circadian Rhythms and Body Weight; Effect of Restricted Feeding (RF) on Circadian Rhythms; Effect of Calorie Restriction (CR) on Circadian Rhythms; Effect of Intermittent Fasting (IF) on Circadian Rhythms; Effect of High-Fat Diet on Circadian Rhythms; Summary Points; References; Chapter 6: Sleep, Energy Homeostasis and Metabolic Syndrome Alterations; Introduction; Sleep Regulation and Function; Metabolic Syndrome; Sleep and Glucose Metabolism; Sleep and Lipid Metabolism; Sleep and Peripheral Appetite Hormones
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Sleep and Cardiovascular Function
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Preface -- Foreword -- Discovery of the Clock mutant and the first mammalian clock gene and the links to obesity: Staring with animal #25 -- An introduction to chronobiology -- Adipose tissue as a peripheral clock -- Processes Underlying Chronodisruption and their Proposed Association with illness -- Obesity and Chronodisrruption: An imbalance between energy intake and expenditure -- Sleep and MetS alterations -- Increased risk of diabetes due to obesity: does chronodisruption play a role? -- Genetics in chronobiology and obesity -- Chronobiology And Metabolic-Syndrome: From Genes To Systems Biology -- Index.
Additional Edition:
ISBN 9781461450818
Additional Edition:
Buchausg. u.d.T. ISBN 978-1-461-45081-8
Language:
English
DOI:
10.1007/978-1-4614-5082-5
URL:
Volltext
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