Format:
Online-Ressource (XVII, 465 p. 74 illus., 38 illus. in color, digital)
ISBN:
9781461452034
Series Statement:
Advances in Biochemistry in Health and Disease 4
Content:
The processes of adaptation and maladaptation play an important role in the pathogeny of serious cardiovascular diseases, such as hypertension, valvular diseases, congenital heart disease, myocardial infarction and different cardiomyopathies as well as during adaptation to exercise and high altitude hypoxia. This volume incorporates the rapidly developing basic and clinically relevant information on adaptive mechanisms, thereby contributing to the better understanding of possible prevention and therapy of life-threatening cardiovascular diseases. The first section of this volume focuses on developmental aspects of cardiac adaptation, including chapters on comparative and molecular aspects of cardiac development, prenatal and postnatal developments, coronary vascular development, and ontogenetic adaptation to hypoxia, as well as cardiac and arterial adaptation during aging. The second section is devoted to cardiac adaptations to overload on the heart, centered around the mechanisms of cardiac hypertrophy due to pressure overload, volume overload, exercise, gender difference, high altitude, and different pathological situations. The third section of this volume highlights the roles of sympathetic nervous system with respect to α-adrenoceptor and β-adrenoceptor mechanisms in the development of cardiac hypertrophy. Cardiac Adaptations will be of great value to cardiovascular investigators, who will find this book highly useful in their cardiovascular studies for finding solutions in diverse pathological conditions; it will also appeal to students, fellows, scientists, and clinicians interested in cardiovascular abnormalities.
Note:
Description based upon print version of record
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Cardiac Adaptations; Preface; Contents; Contributors; Part I Developmental Aspects of CardiacAdaptation; 1 Comparative Aspects of Cardiac Adaptation; Abstract; 1.1…Introduction; 1.2…Comparative Anatomy; 1.3…Relationship Between Heart and Body Weights in the Animal Kingdom; 1.4…Comparative Aspects of the Myocardial Structure/Blood Supply Relationship; 1.5…The Role of Compact Layer in the Adaptive Growth of the Poikilothermic Heart; 1.6…Cardiac Energy Metabolism in Poikilotherms; 1.7…Cold Adaptation of the Poikilothermic Heart
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1.8…AdaptationAdaptation of the Poikilothermic Heart to Chronic Hypoxia1.9…Conclusions; Acknowledgments; References; 2 Molecular Mechanisms of Cardiac Development; Abstract; 2.1…Introduction to CardiogenesisCardiogenesis; 2.2…Transcriptional Regulators of CardiogenesisCardiogenesis; 2.2.1 Nkx2-5; 2.2.2 MEF2C; 2.2.3 Hand1/Hand2; 2.2.4 Tbx5; 2.2.5 Gata4; 2.2.6 Second Heart Field; 2.2.7 Isl1; 2.2.8 Tbx1; 2.2.9 Hand2; 2.3…Proepicardial Organ and Epicardium; 2.3.1 Tbx18; 2.3.2 Wilms Tumor 1; 2.3.3 Epicardially-Derived Cardiac Endothelial Cells; 2.4…miRNAs and Cardiac Development
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3.4.1 Fetal Guinea Pig Model3.4.2 Genetic Mouse Models; 3.5…Human Fetal Studies; 3.5.1 Hypoplastic Left Heart Syndrome; 3.5.2 Abnormal Hemodynamics in Non-Cardiac Malformations; 3.6…Adaptations in Early Postnatal Period; 3.6.1 Physiological Changes After Birth; 3.6.2 Differences in Reaction to Pressure Overload; 3.6.3 Increased Regenerative Potential; 3.6.4 Implications for Neonatal Cardiac Surgery; 3.7…Conclusions and Perspectives; Conflict of Interests:; References; 4 HypoxiaHypoxia and Mechanical Factors Drive Coronary Vascular DevelopmentDevelopment; Abstract; 4.1…Introduction
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4.2…Hypoxia and Neovascularization: General Concepts4.2.1 HIFs Activate Multiple Vascular Growth Factors; 4.2.2 HypoxiaHypoxia Upregulates VEGFVEGF and VEGFR-1 Signaling; 4.2.3 HypoxiaHypoxia and Vessel Sprouting; 4.3…Hypoxia Signaling During Coronary Development; 4.3.1 Derivation of Coronary Vessel Cells; 4.3.2 In Vivo Studies; 4.3.3 Experimentally-Induced HypoxiaHypoxia in Vitro; 4.3.4 Hypoxic Induces Embryonic Stem Cells; 4.3.5 Fetal Coronary DevelopmentDevelopment: Responses to Hypoxemia; 4.3.6 HypoxiaHypoxia and Blood Flow Induce Coronary Growth
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4.3.7 Nitric Oxide and High Coronary Blood Flow
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Comparative Aspects of Cardiac Adaptation -- Molecular Mechanisms in Cardiac Development -- Prenatal Adaptation to Overload -- Hypoxia and Mechanical Factors Drive Coronary Vascular Development -- Cardiac Metabolic Adaptation During Postnatal Development -- Ontogenetic Adaptation to Chronic Hypoxia -- Heart and Arterial Aging -- Differences in Concentric Cardiac Hypertrophy and Eccentric Hypertrophy -- Cardiac Adaptation to Volume Overload -- Functional Adaptation during the Development of Cardiac Hypertrophy and Heart Failure in Females -- Impact of Gender and Exercise on Cardiac Adaptation to Pathological Situations -- Cardiopulmonary Adaptation to High Altitude -- Cardiac Hypertrophy in Hypertension -- Exercise Training and Adverse Cardiac Remodeling and Dysfunction in Mice -- The Athlete’s Heart -- Role of β - Adrenoceptor/Adenylyl Cyclase System in Cardiac Hypertrophy -- Role of Phospholipase C in the α1 - Adrenoceptor Mediated Cardiac Hypertrophy -- Maladaptive Cardiac Remodeling: Signal-dependent Regulation of the Fibrotic Gene Program by CLP-1 in the Hypertrophic Heart -- Role of Sirtuins in Regulation of Cardiac Adaptation Associated with Hypertrophy -- Adaptation of Cardiac and Skeletal Muscle Mitochondria to Endurance Training: Implications for Cardiac Protection -- Adenosine as an Endogenous Adaptive Cardiac Antihypertrophic and Antiremodelling Factor -- Myocardial Adaptation and Autophagy -- Modulatory Role of VEGF in Angiogenesis for Cell Survival -- The Role of CaM Kinase II in Cardiac Function in Health and Disease..
Additional Edition:
ISBN 9781461452027
Additional Edition:
Buchausg. u.d.T. ISBN 978-1-461-45202-7
Language:
English
DOI:
10.1007/978-1-4614-5203-4
URL:
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