UID:
almahu_9949198737802882
Format:
X, 536 p. 163 illus., 1 illus. in color.
,
online resource.
Edition:
1st ed. 2003.
ISBN:
9781592593460
Content:
The advent of molecular genetics, the progression of transgenic animal and plant methodologies from the laboratory to industrial-scale production, and the development of powerful analytical techniques have each helped standardize the culturing of cells to produce desirable commercial products. In Handbook of Industrial Cell Culture: Mammalian, Microbial, and Plant Cells, a diverse team of researchers, technologists, and engineers describe, in simple and practical language, the major current and evolving technologies for improving the biocatalytic capabilities of mammalian, microbial, and plant cells. The authors present state-of-the-art techniques, proven methods, and strategies for industrial screening, cultivation, and scale-up of these cells, and describe their biotechnological and industrial uses. Special emphasis is given to solving the critical issues encountered during the discovery of new drugs, process development, and the manufacture of new and existing compounds. Other topics include recombinant protein expression, bioinformatics, high throughput screening, analytical tools in biotechnology, DNA shuffling, and genomics discovery. The authors all have proven track records in the successful implementation of commercial-scale processes. Cutting-edge and highly practical, the Handbook of Industrial Cell Culture: Mammalian, Microbial, and Plant Cells not only surveys the best current practices in the art of industrial cell culture across cell types, but also delineates today's evolving technologies with examples of proven practical applications, as well as projections of their future potential.
Note:
I. Mammalian Cell Culture -- 1 Analysis and Manipulation of Recombinant Glycoproteins Manufactured in Mammalian Cell Culture -- 2 • Genetic Approaches to Recombinant Protein Production in Mammalian Cells -- 3 • Protein Expression Using Transgenic Animals -- 4 • Mammalian Cell Culture: Process Development Considerations -- II. Microbial Cell Culture -- 5 • Natural Products: Discovery and Screening -- 6 • Genetic Engineering Solutions for Natural Products in Actinomycetes -- 7 • Culture Medium Optimization and Scale-Up for Microbial Fermentations -- III. Plant Cell Culture -- 8 • Functional Genomics for Plant Trait Discovery -- 9 • Molecular Tools for Engineering Plant Cells -- 10 • Plant Cell Culture: A Critical Tool for Agricultural Biotechnology -- 11 • Expression of Recombinant Proteins via the Plastid Genome -- 12 • Oleosin Partitioning Technology for Production of Recombinant Proteins in Oil Seeds -- IV. Critical Tools for Biotechnology -- 13 • Genome Sequencing and Genomic Technologies in Drug Discovery and Development -- 14 • Proteomics -- 15 • Metabolic Flux Analysis, Modeling, and Engineering Solutions -- 16 • Advances in Analytical Chemistry for Biotechnology: Mass Spectrometry of Peptides, Proteins, and Glycoproteins -- 17 • DNA Shuffling for Whole Cell Engineering -- 18 • Cell Culture Preservation and Storage for Industrial Bioprocesses.
In:
Springer Nature eBook
Additional Edition:
Printed edition: ISBN 9781617373152
Additional Edition:
Printed edition: ISBN 9781468497571
Additional Edition:
Printed edition: ISBN 9781588290328
Language:
English
DOI:
10.1007/978-1-59259-346-0
URL:
https://doi.org/10.1007/978-1-59259-346-0
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