UID:
edoccha_9960074463102883
Format:
1 online resource (238 pages)
ISBN:
0-12-815836-0
,
0-12-815508-6
Note:
Front Cover -- BIOMARKERS OF POSTPARTUM PSYCHIATRIC DISORDERS -- BIOMARKERS OF POSTPARTUM PSYCHIATRIC DISORDERS -- Copyright -- Contents -- Contributors -- Preface -- References -- 1 - Clinical phenotypes of peripartum depression and time of onset: the PACT Consortium -- Introduction -- Rationale and creation of the PACT Consortium -- Membership and committees -- Approach -- Specific research aims of the PACT Consortium -- Summary and future directions -- References -- 2 - Genetic basis for postpartum depression -- Introduction -- General approach to genetic studies -- Heritability and familial aggregation of PPD -- Heritability of PPD versus nonpostpartum MDES -- PPD and bipolar disorder -- Genome-wide linkage and association studies -- Candidate gene studies -- Moving forward: approaches for identifyng the genetic basis of PPD -- Conclusions -- References -- 3 - Epigenetic biomarkers of postpartum depression -- Introduction -- Estrogen-based epigenetic studies in postpartum depression -- Oxytocin receptor epigenetic studies of postpartum depression -- Conclusions -- References -- 4 - Potential hormonal and neurochemical biomarkers for postpartum depression -- Introduction -- Neuroactive steroid hormones -- Progesterone and allopregnanolone -- Estrogens -- Testosterone -- The HPA axis -- Thyroid hormones -- The monoamines -- Serotonin -- Epinephrine and norepinephrine -- Dopamine -- Brain-derived Neurotrophic factor -- The microbiome -- Conclusions -- References -- 5 - Immunological biomarkers of postpartum depression -- Introduction -- Early work -- Interleukin 6 -- Other cytokines -- More complex immune markers and associations -- Discussion -- References -- 6 - Phenomenology of perinatal obsessive-compulsive disorder -- Introduction -- Clinical phenomenology -- The nature of obsessive-compulsive disorder.
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Perinatal obsessive-compulsive disorder symptoms -- Comorbidity and differential diagnoses -- Postpartum depression -- Postpartum psychosis -- Prevalence and incidence -- Prenatal obsessive-compulsive disorder -- Postpartum obsessive-compulsive disorder -- Maintaining factors -- Normally occurring intrusive thoughts -- Situational and cognitive factors -- Effects of avoidance and compulsive rituals -- Case vignette -- Summary and conclusions -- References -- 7 - Genetics of perinatal obsessive-compulsive disorder: a focus on past genetic studies to inform future inquiry -- Introduction -- Family and twin studies -- Linkage studies -- Genome-wide association studies -- Candidate genes -- SERT genes -- Dopamine receptor and transporter genes -- COMT gene -- Monoamine oxidase-A gene -- Glutamate transporter gene -- BDNF gene -- Oxytocin receptor -- Estrogen receptor genes -- Conclusion -- References -- Further reading -- 8 - Hormonal contributions to perinatal obsessive-compulsive disorder -- Introduction -- Evidence for contribution by specific hormones -- Estrogen -- Progesterone -- Allopregnanolone -- Oxytocin -- The hypothalamic-pituitaryadrenal axis and cortisol -- Challenges -- Future directions -- References -- 9 - Immunological biomarkers of postpartum obsessive-compulsive disorder -- Introduction -- Autoantibodies and OCD -- Inflammatory biomarkers and OCD -- Leukocyte subpopulations and OCD -- Treatment effects on immune parameters -- OCD in the perinatal period: future directions for immune research -- References -- 10 - Clinical phenotypes of postpartum psychosis -- Introduction -- Terminology -- Epidemiology -- Risk factors -- Clinical presentation -- Assessment and diagnosis -- Differential diagnosis -- Screening and prevention -- References -- 11 - Genetic basis for postpartum psychosis -- Introduction.
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Clinical and epidemiological studies -- Familial association between postpartum psychosis and other mental disorders -- Familial association of the puerperal trigger -- Molecular genetic studies -- Future directions -- References -- 12 - Hormonal and immunological factors in postpartum psychosis -- Introduction -- Hormonal changes associated with postpartum psychosis -- Estrogen -- Progesterone and allopregnanolone -- Oxytocin -- Prolactin -- Stress hormones: CRH, ACTH, and cortisol -- Thyroid hormones -- Immunological changes associated with postpartum psychosis -- Conclusions -- References -- 13 - Functional MRI biomarkers of peripartum psychiatric disorders -- Introduction -- Methods -- Results -- An overview of functional magnetic resonance imaging -- fMRI studies in healthy postpartum and nonpostpartum women -- Unipolar peripartum depression -- fMRI studies in unipolar peripartum depression -- Peripartum bipolar depression -- fMRI findings in nonperipartum bipolar disorder -- Peripartum psychosis -- fMRI findings in nonperipartum psychosis -- Peripartum anxiety disorders and obsessive-compulsive disorder -- fMRI findings in peripartum anxiety -- Peripartum generalized anxiety disorder -- fMRI findings in peripartum generalized anxiety disorder -- Peripartum posttraumatic stress disorder -- fMRI findings in peripartum posttraumatic stress disorder -- Peripartum obsessive-compulsive disorder -- fMRI findings in peripartum obsessive-compulsive disorder -- Discussion -- ACKNOWLEDGMENT -- References -- 14 - Synthesis and future directions -- Because the rate of psychiatric illness increases in the immediate postpartum time period, this period represents a unique ... -- There is much more research on postpartum depression than other postpartum psychiatric illnesses -- Timing of onset of illness may matter.
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It remains unclear if perinatal psychiatric illness is biologically distinct from psychiatric illness outside of the peripartum -- Sensitivity to times of hormonal change may be present in a subset of women with psychiatric illness -- In most areas, it is premature to talk about biomarkers -- It is likely that a combination of factors, including genetics, hormonal changes, and immune system changes, underlie the p ... -- References -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- L -- M -- N -- O -- P -- R -- S -- T -- U -- V -- Z -- Back Cover.
Language:
English
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