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  • 1
    UID:
    almahu_9949281364302882
    Format: 1 online resource (233 p.)
    ISBN: 94-024-2086-X
    Series Statement: NATO Science for Peace and Security Series C: Environmental Security
    Content: Synthetic biology is a field of biotechnology that is rapidly growing in various applications, such as in medicine, environmental sustainability, and energy production. However these technologies also have unforeseen risks and applications to humans and the environment. This open access book presents discussions on risks and mitigation strategies for these technologies including biosecurity, or the potential of synthetic biology technologies and processes to be deliberately misused for nefarious purposes. The book presents strategies to prevent, mitigate, and recover from ‘dual-use concern’ biosecurity challenges that may be raised by individuals, rogue states, or non-state actors. Several key topics are explored including opportunities to develop more coherent and scalable approaches to govern biosecurity from a laboratory perspective up to the international scale and strategies to prevent potential health and environmental hazards posed by deliberate misuse of synthetic biology without stifling innovation. The book brings together the expertise of top scholars in synthetic biology and biotechnology risk assessment, management, and communication to discuss potential biosecurity governing strategies and offer perspectives for collaboration in oversight and future regulatory guidance.
    Note: Description based upon print version of record. , Intro -- Disclaimer -- Acknowledgments -- Contents -- About the Editors -- Chapter 1: Biosecurity for Synthetic Biology and Emerging Biotechnologies: Critical Challenges for Governance -- 1.1 An Introduction to the Dual-Use Nature of Emerging Biotechnology -- 1.2 History -- 1.3 Effective Governance and Policy for Biosecurity -- 1.4 Conclusion -- References -- Chapter 2: Emerging Biosecurity Threats and Responses: A Review of Published and Gray Literature -- 2.1 Introduction -- 2.2 Methods -- 2.3 Results and Discussion -- 2.3.1 US and EU Governmental Frameworks -- 2.3.1.1 US Framework , 2.3.1.2 EU Framework -- 2.3.2 Threats Identified in the Literature -- 2.3.3 Responses Identified in the Literature -- 2.4 Conclusion -- References -- Chapter 3: Opportunities, Challenges, and Future Considerations for Top-Down Governance for Biosecurity and Synthetic Biology -- 3.1 Introduction -- 3.2 Understanding the Scope and Limitations of Top-Down Governance for Biosecurity and Synthetic Biology -- 3.2.1 International Instruments for Biosecurity -- 3.2.1.1 Biological Weapons Convention (BWC) -- 3.2.1.2 Chemical Weapons Convention (CWC) , 3.2.1.3 Australia Group, United Nations Security Council Resolution 1540 and Others -- 3.2.2 National Implementation -- 3.2.2.1 Hard Law vs. Soft Law -- 3.2.2.2 Biosafety vs. Biosecurity, GMOs vs. Synthetic Biology -- 3.2.2.3 National Implementation: An Inevitable Patchwork -- 3.3 Key Novelties and Tensions Introduced by Synthetic Biology -- 3.3.1 Convergence -- 3.3.2 Democratization -- 3.3.3 Intangibility -- 3.4 Conclusions and Recommendations -- References -- Chapter 4: Biological Standards and Biosecurity: The Unexplored Link -- 4.1 Standards in Biology , 4.2 Implications of Standards in Biosecurity in Terms of Risks -- 4.3 Universality -- 4.4 Chassis and Trojan Horses -- 4.5 Breaking Down the Species Barrier -- 4.6 Standards as Social Constructs -- 4.7 Final Remarks and Open Questions -- References -- Chapter 5: Responsible Governance of Biosecurity in Armenia -- 5.1 Introduction -- 5.2 Capacity Building in Dual Use Export Control in TI Partner Countries -- 5.3 Legal Framework Governing Dual Use Life Sciences and Biosecurity , 5.3.1 Protocol for the Prohibition of the Use of Asphyxiating, Poisonous or Other Gases, and of Bacteriological Methods of Warfare - Geneva Protocol of 17 June 1925 -- 5.3.2 The Convention on the Prohibition of the Development, Production and Stockpiling of Bacteriological (Biological) and Toxin Weapons and on Their Destruction -- 5.3.3 United Nation Security Council Resolution No. 1540 (UNSCR 1540) -- 5.3.4 National Laws and Law Enforcement -- 5.4 Ethics of Dual Use Life Sciences -- 5.5 Case Study Life Sciences and Biosecurity in Armenia -- 5.6 Dual Use Life Sciences in Armenia , 5.7 Discussing Ethical Dilemmas , English
    Additional Edition: ISBN 94-024-2085-1
    Language: English
    Keywords: Llibres electrònics ; Konferenzschrift ; Llibres electrònics ; Llibres electrònics ; Llibres electrònics ; Konferenzschrift ; Electronic books.
    URL: Volltext  (kostenfrei)
    URL: Volltext  (kostenfrei)
    URL: Volltext  (kostenfrei)
    URL: Volltext  (kostenfrei)
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Book
    Book
    Champaign, Ill. :AOCS Press,
    UID:
    almafu_BV024396165
    Format: VIII, 438 S. : Ill., graph. Darst.
    ISBN: 0-935315-47-0
    Note: Weitere Ausgabe: Teilausg. von: Analyses of fats, oils and lipoproteins
    Subjects: Chemistry/Pharmacy
    RVK:
    Library Location Call Number Volume/Issue/Year Availability
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  • 3
    UID:
    gbv_436928051
    Format: XVI, 456 S , Ill., Kt , 8°
    Language: English
    Keywords: Reise ; Australien
    Library Location Call Number Volume/Issue/Year Availability
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  • 4
    UID:
    gbv_1778405495
    Format: 1 Online-Ressource (225 p.)
    ISBN: 9789402420869
    Series Statement: NATO Science for Peace and Security Series C: Environmental Security
    Content: Synthetic biology is a field of biotechnology that is rapidly growing in various applications, such as in medicine, environmental sustainability, and energy production. However these technologies also have unforeseen risks and applications to humans and the environment. This open access book presents discussions on risks and mitigation strategies for these technologies including biosecurity, or the potential of synthetic biology technologies and processes to be deliberately misused for nefarious purposes. The book presents strategies to prevent, mitigate, and recover from ‘dual-use concern’ biosecurity challenges that may be raised by individuals, rogue states, or non-state actors. Several key topics are explored including opportunities to develop more coherent and scalable approaches to govern biosecurity from a laboratory perspective up to the international scale and strategies to prevent potential health and environmental hazards posed by deliberate misuse of synthetic biology without stifling innovation. The book brings together the expertise of top scholars in synthetic biology and biotechnology risk assessment, management, and communication to discuss potential biosecurity governing strategies and offer perspectives for collaboration in oversight and future regulatory guidance
    Note: English
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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  • 5
    Book
    Book
    Champaign, Ill. :American Oil Chemists' Soc.,
    UID:
    almafu_BV024390197
    Format: VIII, 664 S. : Ill., graph. Darst.
    ISBN: 0-935315-36-5
    Subjects: Chemistry/Pharmacy
    RVK:
    Library Location Call Number Volume/Issue/Year Availability
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  • 6
    Book
    Book
    London :British Council,
    UID:
    almafu_BV026586679
    Format: S. 99 - 184 : , Ill., graph. Darst.
    Series Statement: British medical bulletin 26,2
    Language: English
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  • 7
    UID:
    gbv_1747662372
    Format: 1 Online-Ressource (57 p.)
    Series Statement: OECD Series on Adverse Outcome Pathways no.11
    Content: This AOP begins with the interaction of chemicals to the picrotoxin binding site of the ionotropic GABA receptor complex causing blockage of the ion channel. As a result, decrease in inward chloride conductance occurs, followed by a reduction in postsynaptic inhibition, reflected as reduced frequency and amplitude of spontaneous inhibitory postsynaptic current or abolishment of GABA-induced firing action. Consequently, the resistance of excitatory neurons to fire is decreased, resulting in the generation of a large excitatory postsynaptic potential (EPSP) that causes voltage-gated Na+ to open, which results in action potentials. The depolarisation is followed by a period of hyper-polarisation mediated by Ca2+-dependent K+ channels or GABA-activated Cl− influx, which becomes smaller, gradually disappears, and is replaced by a depolarisation known as “paroxysmal depolarizing shift” (PDS). A PDS is an indication of epilepsy at the cellular level and initiates the adverse outcome at the organismal level of epileptic seizure.
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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  • 8
    UID:
    b3kat_BV047932010
    Format: 1 Online-Ressource (57 Seiten)
    Series Statement: OECD Series on Adverse Outcome Pathways
    Content: This AOP begins with the interaction of chemicals to the picrotoxin binding site of the ionotropic GABA receptor complex causing blockage of the ion channel. As a result, decrease in inward chloride conductance occurs, followed by a reduction in postsynaptic inhibition, reflected as reduced frequency and amplitude of spontaneous inhibitory postsynaptic current or abolishment of GABA-induced firing action. Consequently, the resistance of excitatory neurons to fire is decreased, resulting in the generation of a large excitatory postsynaptic potential (EPSP) that causes voltage-gated Na+ to open, which results in action potentials. The depolarisation is followed by a period of hyper-polarisation mediated by Ca2+-dependent K+ channels or GABA-activated Cl− influx, which becomes smaller, gradually disappears, and is replaced by a depolarisation known as "paroxysmal depolarizing shift" (PDS). A PDS is an indication of epilepsy at the cellular level and initiates the adverse outcome at the organismal level of epileptic seizure
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 9
    UID:
    almahu_9949177828402882
    Format: XV, 225 p. 15 illus., 13 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789402420869
    Series Statement: NATO Science for Peace and Security Series C: Environmental Security,
    Content: Synthetic biology is a field of biotechnology that is rapidly growing in various applications, such as in medicine, environmental sustainability, and energy production. However these technologies also have unforeseen risks and applications to humans and the environment. This open access book presents discussions on risks and mitigation strategies for these technologies including biosecurity, or the potential of synthetic biology technologies and processes to be deliberately misused for nefarious purposes. The book presents strategies to prevent, mitigate, and recover from 'dual-use concern' biosecurity challenges that may be raised by individuals, rogue states, or non-state actors. Several key topics are explored including opportunities to develop more coherent and scalable approaches to govern biosecurity from a laboratory perspective up to the international scale and strategies to prevent potential health and environmental hazards posed by deliberate misuse of synthetic biology without stifling innovation. The book brings together the expertise of top scholars in synthetic biology and biotechnology risk assessment, management, and communication to discuss potential biosecurity governing strategies and offer perspectives for collaboration in oversight and future regulatory guidance.
    Note: Chapter 1: Biosecurity for Synthetic Biology and Emerging Biotechnologies: Critical Challenges for Governance -- Chapter 2: Emerging Biosecurity Threats and Responses: A Review of Published and Gray Literature -- Chapter 3: Opportunities, Challenges, and Future Considerations for Top-Down Governance for Biosecurity and Synthetic Biology -- Chapter 4: Biological standards and biosecurity: The unexplored link -- Chapter 5: Responsible Governance of Biosecurity in Armenia -- Chapter 6: Addressing Emerging Synthetic Biology Threats: The Role of Education and Outreach in Fostering Effective Bottom-Up Grassroots Governance -- Chapter 7: Cybersecurity and Public Health in the Age of COVID-19 -- Chapter 8: Synthetic Biology Brings New Challenges to Managing Biosecurity and Biosafety -- Chapter 9: Emerging Biotechnology and Information Hazards -- Chapter 10: Technical Aspects of Biosecurity: Screening Guidance, Attribution, and Traceability -- Chapter 11: The Soil Habitat and Considerations for Synthetic Biology -- Chapter 12: Foresight in Synthetic Biology and Biotechnology Threats -- Chapter 13: Predicting Biosecurity Threats: Deployment and Detection of Biological Weapons -- Chapter 14: Promoting Effective Biosecurity Governance: Using Tripwires to Anticipate and Ameliorate Potentially Harmful Development Trends. .
    In: Springer Nature eBook
    Additional Edition: Printed edition: ISBN 9789402420852
    Additional Edition: Printed edition: ISBN 9789402420876
    Additional Edition: Printed edition: ISBN 9789402420883
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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  • 10
    UID:
    gbv_1747693898
    Format: 1 Online-Ressource (83 p.)
    Series Statement: OECD Series on Adverse Outcome Pathways no.10
    Content: The present AOP describes antagonistic chemical binding to the peroxisome proliferator-activated receptor α (PPARα), resulting in preferential binding a co-repressor to the overall PPARα signalling complex causing a chain of events that includes: antagonism of PPARα nuclear signalling, decreased transcriptional expression of PPARα-regulated genes that support energy metabolism, inhibited metabolic energy production (decreased fatty acid beta oxidation and ketogenesis), and increase in catabolism of muscle protein, culminating with starvation-like weight loss. The AOP is likely to be synergised during fasting, starvation or malnutrition events. The adverse outcome of this AOP is body-weight loss, which within the context of dynamic energy budget theory, decreases energy allocations to organismal maturation and reproduction and has been demonstrated to negatively affect ecological fitness.
    Language: English
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