UID:
almafu_9958068616102883
Format:
1 online resource (203 p.)
ISBN:
1-280-94094-8
,
9786610940943
,
3-8055-8075-4
Series Statement:
Endocrine development, vol. 10
Content:
As is the case in all fields of medicine, developmental endocrinology is now being studied at the molecular level. In this volume world-class researchers review the advances of the past decade in the study of normal and abnormal organogenesis of the thyroid gland and of the ontogeny of its function. They describe human thyroid development and its defects with the help of genetic studies in mouse models. Genetic defects of thyroid hormone synthesis are covered and their clinical relevance debated. The important field of thyroid cancer in the context of spontaneous occurrence and as part of familial neoplasia syndromes is described in detail. Finally, the important problem of environmental iodine deficiency which has emerged as a global public health concern is addressed. For the first time, a decade of work is presented in a concise and highly readable form. Offering valuable insight both for senior clinicians and graduate students, this publication will be of central interest to basic scientists involved in developmental biology as well as to pediatricians and endocrinologists dealing with patients with congenital disorders of thyroid function.
Note:
Description based upon print version of record.
,
""Cover""; ""Contents""; ""Foreword""; ""Preface""; ""Disorders of Thyroid Gland Development""; ""Murine Models for the Study of Thyroid Gland Developmen""; ""Abstract""; ""Introduction""; ""Genetics of Early Stages of Thyroid Development""; ""Specification of the Thyroid Anlage""; ""Budding of the Thyroid Primordium""; ""Hhex""; ""Titf1""; ""Pax8""; ""Migration of the Thyroid Primordium""; ""Gene Interactions at Early Stages of Thyroid Morphogenesis""; ""Genetics of Late Stages of Thyroid Development""; ""Lobulation""; ""Functional Differentiation""; ""Expansion of the Fetal Thyroid""
,
""From Mouse Models to Human Diseases""""References""; ""Familial Forms of Thyroid Dysgenesis""; ""Abstract""; ""Introduction""; ""Thyroid Development""; ""Different Types of TD""; ""Familial Forms of CH due to TD""; ""Familial Forms of TD in First-Degree Relatives of Children with CH""; ""Molecular Mechanisms of Thyroid Developmental Abnormalities""; ""Acknowledgment""; ""References""; ""Possible Non-Mendelian Mechanisms of Thyroid Dysgenesis""; ""Abstract""; ""Introduction""; ""How to Define and Classify Patients with Thyroid Dysgenesis?""; ""Early Somatic Mutations""
,
""Epigenetic Modifications""""Towards a Unifying Hypothesis Combining Germline and Somatic Changes in a Two-Hit Model""; ""Acknowledgments""; ""References""; ""Thyroid Imaging in Children""; ""Abstract""; ""Normal Appearance of the Thyroid Gland on US""; ""Technique""; ""Developmental Abnormalities of the Thyroid Gland with or without Hypothyroidism""; ""Chronic Autoimmune Thyroiditis""; ""Acute Thyroiditis""; ""Hyperthyroidism""; ""Thyroid Nodules""; ""Thyroid Tumours""; ""Conclusion""; ""References""; ""Disorders of Thyroid Function""
,
""Clinical and Biological Consequences of Iodine Deficiency during Pregnancy""""Abstract""; ""Introduction""; ""Regulation of Thyroid Function during Pregnancy""; ""Metabolism of Iodine during Pregnancy""; ""Epidemiology and Management of ID during Pregnancy""; ""Epidemiological Aspects""; ""Managerial Aspects""; ""Monitoring the Adequacy of Iodine Intake""; ""Consequences of ID during Pregnancy""; ""Biological Consequences""; ""Goiter Formation""; ""Long-Term Consequences of Gestational Goitrogenesis""; ""Prevention of Gestational Goiter Due to ID""; ""Pregnancy in Regions with Severe ID""
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""Fetal and Neonatal Consequences of Maternal ID and Thyroid Underfunction""""Conclusions and Perspectives""; ""Acknowledgments""; ""References""; ""Ontogenesis of Thyroid Function and Interactions with Maternal Function""; ""Abstract""; ""Ontogenesis of Thyroid Function""; ""The Influence of Maternal Thyroid Hormones until Midgestation""; ""Findings from Experimental Rat Models""; ""Findings in the Human Fetus""; ""From Conception to Midgestation""; ""Availability of Thyroid Hormones to the Fetus from Midgestation to Birth""; ""Fluids of the Fetal Compartment and Fetal Brain""
,
""The Role of the Mother from Midgestation to Birth""
,
English
Additional Edition:
ISBN 3-8055-8296-X
Language:
English
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