Kooperativer Bibliotheksverbund

UID:

Format: 1 online resource (509 p.)

ISBN: 0-85709-671-0

Series Statement: Woodhead Publishing Series in Biomaterials ; Number 72

Content: Heart disease is the leading cause of death in the Western World and heart failure following a myocardial infarction continues to increase despite urgent revascularization. Cell therapy offered the promise to reverse cardiac injury and prevent heart failure, but the initial clinical trials were not as effective as anticipated. New approaches to restore ventricular function are urgently needed. Cardiac regeneration and repair Volume 2 reviews the use of biomaterials, alone or combined with cell therapy, to provide tissue engineered constructs to repair the injured heart and prevent or reverse h

Note: Description based upon print version of record. , Cover; Cardiac regeneration and repair: Volume 2: Biomaterials and tissue engineering; Copyright; Contents; Contributor contact details; Woodhead Publishing Series in Biomaterials; Foreword; Introduction; Part I Biomaterials for cardiac regeneration and repair; 1 Nanotechnology and nanomaterials for cardiac repair; 1.1 Introduction; 1.2 Electrospinning nanofibrous scaffolds; 1.3 Conductive nanomaterial for myocardial infarction (MI); 1.4 Nanomedicine; 1.5 Future trends; 1.6 References; 2 Hydrogels for cardiac repair; 2.1 Introduction; 2.2 Hydrogels , 2.3 Injectable hydrogels alone for cardiac repair2.4 Hydrogels as a platform for co-delivery; 2.5 Delivery strategies of hydrogels; 2.6 Future trends; 2.7 Sources of further information and advice; 2.8 References; 3 Injectable biomaterials for cardiac regeneration and repair; 3.1 Introduction; 3.2 Design criteria for biomaterials in cardiac tissue engineering; 3.3 Injectable biomaterials; 3.4 Bioactive molecules used in cardiac tissue engineering; 3.5 Hydrogels to promote endogenous cardiac regeneration and repair; 3.6 Hydrogels for the delivery of cells for cardiac regeneration , 3.7 Hydrogels for the artificial maintenance of ventricle geometry and repair3.8 Future trends; 3.9 References; 4 Biomaterials for enhancing endothelial progenitor cell (EPC) therapy for cardiac regeneration; 4.1 Introduction; 4.2 Endothelial progenitor cells (EPCs); 4.3 Enhancing EPC therapy; 4.4 Future trends; 4.5 Conclusion; 4.6 References; 5 Endothelial progenitor cell (EPC)-seeded intravascular stents; 5.1 Intravascular stents; 5.2 Endothelial progenitor cells (EPCs); 5.3 EPC-seeded intravascular stents; 5.4 Conclusion; 5.5 Sources of further information and advice; 5.6 References , Part II Tissue engineering for cardiac regeneration and repair6 Biomaterials and cells for cardiac tissue engineering; 6.1 Introduction; 6.2 Cardiac structure; 6.3 Cardiac remodeling in myocardial infarction (MI); 6.4 Cells for cardiac tissue engineering; 6.5 Materials for cardiac tissue engineering; 6.6 Creation of heart tissue using cell and biomaterials: an in vitro approach; 6.7 Creation of heart tissue using cell andbiomaterials: an in vivo approach ofinjectable matrices; 6.8 Vascularization in myocardial tissue engineering; 6.9 Ventricular aneurysm repair using cells and biomaterials , 6.10 Clinical applications6.11 Conclusion and future trends; 6.12 References; 7 Decellularized biological scaffolds for cardiac repair and regeneration; 7.1 Introduction; 7.2 Methods of bioscaffold preparation; 7.3 Cardiac repair with non-cardiac bioscaffolds; 7.4 Tissue specificity of extracellular matrix bioscaffolds; 7.5 Current methods for decellularizing cardiac tissue; 7.6 Whole organ engineering; 7.7 References; 8 Biomaterial scaffolds for cardiac regeneration and repair derived from native heart matrix; 8.1 Heart failure and cardiac tissue engineering , 8.2 Extracellular matrix (ECM) as a biomaterial , English

Additional Edition: ISBN 0-85709-659-1

Language: English

UID:

Format: 1 online resource (459 p.)

ISBN: 0-85709-670-2

Series Statement: Woodhead Publishing Series in Biomaterials ; Number 71

Content: Heart disease is the leading cause of death in the Western World and heart failure following a myocardial infarction continues to increase despite urgent revascularization. Cell therapy offered the promise to reverse cardiac injury and prevent heart failure, but the initial clinical trials were not as effective as anticipated. New approaches to improve the benefits of cell therapy are urgently needed. Cardiac regeneration and repair Volume 1 reviews the pathology of cardiac injury and the latest advances in cell therapy.Chapters in part one explore the pathogenesis of congestive heart

Note: Description based upon print version of record. , Cover; Cardiac regeneration and repair: Volume 1: Pathology and therapies; Copyright; Contents; Contributor contact details; Woodhead Publishing Series in Biomaterials; Foreword; Introduction; Part I The pathogenesis of congestive heart failure; 1 Cardiac matrix remodeling and heart failure; 1.1 Introduction; 1.2 Cardiac matrix remodeling in the development and progression of heart failure (HF) after myocardial infarction (MI); 1.3 Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in matrix and cardiac remodeling , 1.4 Role of infl ammation in matrix and cardiac remodeling1.5 Role of monocytes and macrophages in matrix and cardiac remodeling; 1.6 Extracellular matrix (ECM) and collagen deposition; 1.7 Treatment strategies and considerations; 1.8 Future trends; 1.9 Acknowledgments; 1.10 References; 2 Cardiac biomechanics and heart dysfunction; 2.1 Introduction; 2.2 Measures of cardiac biomechanics; 2.3 Techniques for assessing the parameters used to quantify cardiac function; 2.4 Passive versus active cardiac function; 2.5 Effects of ischemia and infarction on cardiac biomechanics; 2.6 Conclusion , 2.7 References3 Modifying matrix remodeling to prevent heart failure; 3.1 Introduction; 3.2 Clinical progress and remaining issues; 3.3 Extracellular matrix (ECM) remodeling in the postmyocardial infarction setting; 3.4 Cells that modify ECM remodeling; 3.5 Therapeutic options; 3.6 Future trends; 3.7 Conclusion; 3.8 Sources of further information and advice; 3.9 Acknowledgements; 3.10 References; Part II Cell therapy for cardiac regeneration and repair; 4 Optimal cells for cardiac repair and regeneration; 4.1 Introduction; 4.2 Cell candidates for the repair of ischemic myocardium , 4.3 Mechanisms of stem cell transplantation for myocardium repair4.4 Overview of the centers for cardiac cell transplantation; 4.5 Conclusion and future trends; 4.6 References; 4.7 Appendix: abbreviations and acronyms; 5 Cell delivery routes for cardiac stem cell therapy; 5.1 Introduction; 5.2 Intravenous (IV) injection for cell therapy to the heart; 5.3 Intramyocardial (IM) injection for cell therapy to the heart; 5.4 Intracoronary (IC) injection for cell therapy to the heart; 5.5 Advanced methods for cell therapy to the heart: tissue engineering and the cellsheet technique , 5.6 Conclusion and future trends5.7 Acknowledgment; 5.8 References; 6 Cell therapy to regenerate the ischemic heart; 6.1 Introduction; 6.2 Pathology of ischemic damage; 6.3 Goals and mechanisms of cell therapy to regenerate the ischemic heart; 6.4 Candidate populations for cell therapy; 6.5 Variables of cell therapy; 6.6 Conclusion; 6.7 References; 7 Cell therapy for cardiac repair - bench to bedside and back; 7.1 Introduction; 7.2 Transition of stem cell therapeutics from the bench to the clinic; 7.3 Skeletal myoblasts; 7.4 Hematological stem cell (HSC) products; 7.5 Conclusion , 7.6 References , English

Additional Edition: ISBN 0-85709-658-3

Language: English

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Format: 1 online resource (250 pages).

ISBN: 0-12-814071-2

Series Statement: Translational epigenetics series ; Volume 7

Note: Front Cover -- Epigenetics of Chronic Pain -- Copyright -- Contents -- Contributors -- Preface -- Chapter 1: Epigenetic Tools in Chronic Pain Studies -- Introduction -- Measurement of Molecular Changes -- Sample Preparation -- DNA Methylation/Demethylation -- Genome-wide association studies -- Methylation -- Demethylation -- Gene-specific studies -- Chromatin Remodeling/Histone Modifications -- Global versus genome wide detection -- Gene specific studies of histone modification -- Noncoding RNA -- miRNA assay -- Studies of miRNA functions -- Studies of lncRNAs -- Fourth Epigenetic Mechanism -- Manipulation of Epigenetic Mechanisms -- Pharmacological Tools -- Inhibition of enzymes for DNA methylation/demethylation -- Activator and inhibitor for histone acetylation and deacetylation -- Inhibitor for histone methylation and demethylation -- Genetic Modification of Epigenetic Components -- Classic approaches -- EpiEditors -- Closing Remark -- Acknowledgements -- References -- Chapter 2: Epigenetic Regulation of Peripheral Macrophages in Neuropathic Pain -- Introduction -- Peripheral Sensitization in Neuropathic Pain -- Macrophage Infiltration and Cytokine Production -- Macrophage Polarization in Neuropathic Pain -- Chemokine Systems and Inflammation -- Peripheral Chemokines in Neuropathic Pain -- Epigenetic Regulation of Gene Expression -- Histone Modifications and Chemokine Production -- Epigenetic Regulation of Chemokines and Neuropathic Pain -- Conclusions and Future Directions -- Acknowledgments -- Conflicts of Interest -- References -- Chapter 3: Emphasizing Histone-Related Chromatin Remodeling in the Central Nervous System of Animal Models of Chronic Pain -- Histone-Related Chromatin Remodeling -- Neuropathic Pain Model -- Partial Sciatic Nerve Ligation (PSL) Model (Table 1) -- Spinal Nerve Ligation (SNL) Model (Table 1). , Chronic Constriction Injury (CCI) Model (Table 2) -- Spared Nerve Injury (SNI) Model (Table 2) -- Chemotherapy-Induced Neuropathic Pain Model (Table 2) -- Inflammatory Pain Model -- CFA-Induced Inflammation Model (Table 3) -- MIA-Induced Inflammation Model (Table 4) -- Other Pain Model -- Opioid-Induced Hyperalgesia Model (Table 5) -- Hindpaw Incision Model (Table 5) -- Conclusions and Perspectives -- Acknowledgment -- References -- Chapter 4: Role of Histone Modifications in Chronic Pain Development -- Histone Methylation -- H3K9me2 and H3K9me3 -- H3K27me3 -- H3K4me3 -- Histone Acetylation -- Histone Variants -- Other Histone-Modifying Factors -- Perspectives -- Chapter 5: Role of DNA Methylation in Chronic Pain -- Introduction -- The Process of DNA Methylation -- DNA Methylation and Neuropathic Pain -- DNA Methylation and Inflammatory Pain -- DNA Methylation and Cancer Pain -- Methyl-CpG-Binding Domain Proteins (MBDs) and Chronic Pain -- DNA Methylation and Clinical Painful Diseases -- Conclusion & Future Perspective -- References -- Chapter 6: Pain-Induced Chromatin Modifications -- Introduction -- Chromatin Modifications for Transcriptional Regulations -- Histone Modifications -- Noncoding RNAs -- DNA Methylation -- Histone Modifications in Chronic Pain -- Noncoding RNAs in Chronic Pain -- DNA Methylation in Chronic Pain -- Conclusion and Future Directions -- References -- Chapter 7: DNA Methylation/Demethylation Homeostasis and Various Pain Conditions -- Introduction -- DNA Methylation and Demethylation -- Emerging Technologies for Studying DNA Methylation and Demethylation -- DNA Methylation/Demethylation and Transcriptional Regulation -- DNA Methylation and Transcriptional Repression -- DNA Demethylation and Transcriptional Activation -- Role of DNA Methylation in Chronic Pain: An Imbalance Between Methylation and Demethylation. , Mechanisms Underlying the DNA Methylation and Demethylation -- Enhanced Binding Ability of the Demethylated Gene With the Transcription Factor -- Future Treatment Options by Drugging the DNA Methylome -- Concluding Remarks -- Acknowledgements -- References -- Chapter 8: Epigenetic Modulation of Visceral Pain -- Introduction -- Visceral Pain -- Types of Visceral Pain -- Characteristics of Visceral Pain -- Visceral Pain Pathways -- Monitoring Methods of Visceral Pain -- Animal Models of Visceral Pain -- Epigenetic Mechanisms in Visceral Pain -- DNA Methylation in Visceral Pain -- Histone Acetylation in Visceral Pain -- MicroRNA Activities in Visceral Pain -- Conclusion and Future Strategies -- Acknowledgments -- References -- Chapter 9: Noncoding RNAs Are New Players in Chronic Pain -- Introduction -- miRNAs in Chronic Pain -- Long Noncoding RNAs in Chronic Pain -- Circular RNAs in Chronic Pain -- Conclusion -- References -- Chapter 10: Epigenetics of Chronic Visceral Nociception -- Chronic Visceral Pain: A Major Health Care Concern -- Neurobiology of Visceral Nociception -- Modulating Factors of Afferent Input -- Epigenetic Alterations -- Conclusions -- References -- Chapter 11: An Overview of Epigenetic Correlates of Human Chronic Pain Conditions -- Introduction -- Epigenetic Marks and Chronic Pain -- Fibromyalgia and Chronic Widespread Pain -- Role of DNA methylation -- Role of microRNAs -- Headache -- Cancer Pain -- Low Back Pain -- Diabetic Neuropathy -- Chronic Postsurgical Pain -- Neonatal Stress-Related Pain -- Visceral Pain-Irritable Bowel Syndrome (IBS) and miRNA Profiles -- Complex Regional Pain Syndrome and miRNA Profiles -- Sex Differences in miRNA Profiles in Trauma/Stress Pain -- Transient Receptor Potential Cation Channel A1 (TRPA1) and Neuropathic Pain -- Opioid Receptors -- Epigenetics in Painful Disease Conditions. , Rheumatoid Arthritis -- DNA hypomethylation -- Histone code -- Osteoarthritis -- Endometriosis -- Myalgic Encephalomyelitis/Chronic Fatigue Syndrome -- Inflammatory Bowel Diseases and Crohn's Disease -- Periodontal Disease -- Translation and Therapeutic Potential -- General Comments and Concluding Remarks -- Blood-Based Analysis and Brain Epigenetics -- Cell and Tissue-Specificity of Altered Epigenetics -- Implications of Differential Genomic Methylation -- Confounding Factors in Human Epigenetic Studies -- Age -- Sex -- Other factors -- Concluding Remarks -- Acknowledgments -- References -- Index -- Back Cover.

Additional Edition: ISBN 0-12-814070-4

Language: English

UID:

Format: Online-Ressource

Original writing title: 日本技术的前十年与后十年

Note: 科研管理参考资料

Language: Chinese

URL: Volltext

UID:

Format: Online-Ressource

Original writing title: 国家注册实验室质量体系内部审核员培训教程

ISBN: 7505820478

Language: Chinese

URL: Volltext

UID:

Format: 1 online resource (196 pages)

Content: Conflict between resolution and total computational effort is a long term issue challenging scientists who are committed to develop computational tools with concerns of both accuracy and efficiency. The work is to implement the robust and effective LMR in the solution of Euler equations, the solution of Navier-Stokes equations and the simulation of detonation.

Note: Background -- Review of combustion codes, LMR and load balancing. -- Implementation of LMR in COM3D -- Load Balancing. -- Application of LMR -- Conclusions and future work -- References -- Appendix A -- Appendix B -- Appendix C -- Appendix D -- Appendix E -- Appendix F.

Language: English

DOI: 10.5445/KSP/1000041147

UID:

Format: Online-Ressource

Edition: 2版(修订版)

Original writing title: 中国实验室注册评审员培训教程

ISBN: 7502611932

Language: Chinese

URL: Volltext

UID:

Format: 6 册 , 地图

Edition: 据 1948 年铅印本影印

Original writing title: 贵州通志 卷首十九编一百七十卷 : 民国

Original writing person/organisation: 刘显世

Original writing publisher: 成都 : 巴蜀书社

Series Statement: zhong guo di fang zhi ji cheng / gui zhou fu xian zhi ji 6/11,1

Note: SBB-PK Berlin

Language: Chinese

UID:

Format: 1 册

Edition: Online-Ausgabe Bei jing 2012 1 Online-Ressource Min guo tu shu shu ju ku = Early Twentieth Century Book in China, 1911-1949. tu shu ; yi qi

Original writing title: 教育进化史

Original writing person/organisation: 民友社

Original writing publisher: 上海 : 普益书局

Note: Pinyin-Umschrift und Langzeichen wurden automatisiert erstellt , System requirements: Internet browser, Acrobat reader with Adobe simplified Chinese fonts.

Language: Chinese

URL: lizenzpflichtig

URL: lizenzpflichtig

UID:

Format: 62 Seiten , 10 x 8 cm

Edition: 1985年02月第1版, 1985年02月第1次印刷

Original writing title: “年”除“夕”的故事 : (一)

Original writing person/organisation: 任可

Original writing publisher: 上海 : 上海人民美术出版社

Series Statement: Nian de gu shi 1

Content: La yue san shi wei shi me jiao chu xi? Ren men wei shi me yao guo nian? Guo nian de shi hui wei shi me yao fang bao zhu, tie dui lian? Da jia yi ding hen xiang zhi dao zhei xie you qu de shi qing, zhe ge liu chuan zai min jian de gu shi jiang ba zhe yi qie dou gao su ni. '''Nian' chu 'xi' de gu shi'' gong fen wei san ce, zhe shi di yi ce. Shuo de shi ren jian chu le yi ge jiao ''xi'' de guai shou, mei feng la yue san shi jiu dao ren jia jia li qiang chi de, wei hai bai xing. Zao wang ye shang tian qing le shen nong de er zi, yi ge jiao ''nian'' de xiao shen ling lai ren jian chu hai......

Content: 腊月三十为什么叫除夕?人们为什么要过年?过年的是会为什么要放爆竹、贴对联?大家一定很想知道这些有趣的事情，这个流传在民间的故事将把这一切都告诉你。《''年''除''夕''的故事》共分为三册，这是第一册。说的是人间出了一个叫''夕''的怪兽，每逢腊月三十就到人家家里抢吃的，危害百姓。灶王爷上天请了神农的儿子，一个叫''年''的小神灵来人间除害......

Note: Enthält Zusammenfassung

Language: Chinese

Keywords: Comic ; Kinderbuch