Format:
Online-Ressource (XVIII, 211 p. 64 illus., 58 illus. in color, digital)
ISBN:
9789400765702
,
9789400765696
Series Statement:
SpringerLink
Content:
In this book we have taken a comprehensive look at the subject of familial and hereditary gastric tumors. In particular, the aim of this novel editorial work is to propose the correct management of hereditary diffuse gastric cancer patients, focusing in particular on E-cadherin germline mutations, clinical criteria definition, genetic screening and molecular mechanisms, pathology and microscopic features, surgical treatment and clinical approach for asymptomatic mutation carriers. We also describe other inherited predispositions involving gastric carcinoma.
Content:
In this book we have taken a comprehensive look at the subject of familial and hereditary gastric tumors. In particular, the aim of this novel editorial work is to propose the correct management of hereditary diffuse gastric cancer patients, focusing in particular on E-cadherin germline mutations, clinical criteria definition, genetic screening and molecular mechanisms, pathology and microscopic features, surgical treatment and clinical approach for asymptomatic mutation carriers. We also describe other inherited predispositions involving gastric carcinoma
Note:
Description based upon print version of record
,
Foreword; References; Preface; Contents; Contributors; Part I: General Issues; Chapter 1: Historical Overview of Familial Gastric Cancer; 1.1 Introduction; 1.2 The Māori Ethnicity; 1.2.1 The Māori Pedigree; 1.3 The Emperor Napoleon Bonaparte; 1.3.1 The Clinical History of Napoleon Bonaparte; 1.4 Pope John XXIII; 1.4.1 The Clinical History of John XXIII; 1.5 Conclusion; References; Chapter 2: Frequency of Familial Gastric Cancer; 2.1 Introduction; 2.2 The Incidence Rate of Familial Gastric Cancer; 2.3 CDH1 Mutations and Geographic Variability; 2.4 Prognosis and Long-Term Survival
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2.5 Cancer Risk2.6 Conclusion; References; Chapter 3: The Family Cancer Database; 3.1 Data Collection; 3.2 Family Cancer Database; Part II: Genetics and Epigenetics; Chapter 4: The E-Cadherin Gene, Structure and Function; 4.1 Introduction; 4.2 Human E-Cadherin Structure; 4.3 E-Cadherin Function; 4.4 CDH1 Gene Deregulation; References; Chapter 5: E-Cadherin Germline Mutations; 5.1 Introduction; 5.2 E-Cadherin Mutations in Hereditary Disorders; 5.2.1 Hereditary Diffuse Gastric Cancer; 5.2.2 Inherited E-Cadherin-Associated Lobular Breast Cancer
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5.2.3 E-Cadherin-Related Cleft Lip with or Without Cleft Palate5.2.4 Early-Onset Diffuse Gastric Cancer; 5.3 Final Remarks on E-Cadherin-Associated Disorders; References; Chapter 6: Molecular Mechanisms of Hereditary Diffuse Gastric Cancer Initiation and Progression; 6.1 Introduction; 6.2 Multifocality of Early Stage Cancer in Hereditary Diffuse Gastric Cancer; 6.3 Tumour Initiation: Mechanisms of 2nd CDH1 Hit; 6.4 Impact of CDH1 Loss on the Epithelial Monolayer; 6.5 Origin and Indolent Nature of Stage T1a Signet Ring Cell Carcinoma; 6.6 Role of the Epithelial-Mesenchymal Transition
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6.7 Parallels with Progression of Sporadic Diffuse Gastric Cancer6.7.1 EMT; 6.7.2 Stem Cells; 6.8 Concluding Remarks; References; Chapter 7: Germline Missense Mutants in Hereditary Diffuse Gastric Cancer; 7.1 Introduction; 7.2 Occurrence of CDH1 Missense Mutations; 7.3 Models to Study the Pathogenic Relevance of CDH1 Germline Missense Mutations. In Silico and In Vitro Approaches; 7.4 CDH1 Missense Mutations and Their Cellular Consequences: Protein Trafficking and Signal Transduction; References; Chapter 8: Alternative Mechanisms to Germline CDH1 Mutations in Hereditary Diffuse Gastric Cancer
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8.1 Introduction8.2 CDH1 Germline Deletions; 8.3 CDH1 Germline Promoter Methylation; 8.4 CDH1 Germline Allelic Imbalance; 8.5 Conclusion; References; Chapter 9: Beyond CDH1 Mutations: Causes of Hereditary Diffuse Gastric Cancer; 9.1 Introduction; 9.2 Previous Diagnostic Sequencing Techniques; 9.3 Advancements in Sequencing Technology: Next Generation Sequencing; 9.3.1 Advances in Sequencing Platforms; 9.3.2 Multiplexing; 9.3.3 Whole Genome Sequencing; 9.3.4 Exome Sequencing; 9.3.5 Targeted Amplicon-Based Sequencing; 9.4 Ethical Implications of Next Generation Sequencing
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9.5 Future Direction of Hereditary Diffuse Gastric Cancer: Utilizing Next Generation Sequencing
Additional Edition:
ISBN 9789400765696
Additional Edition:
Erscheint auch Druck-Ausgabe Spotlight on Familial and Hereditary Gastric Cancer Dordrecht : Springer, 2013 ISBN 9789400765696
Language:
English
Subjects:
Medicine
DOI:
10.1007/978-94-007-6570-2
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