Format:
Online-Ressource (PDF-Datei: VI, 107 S.)
ISBN:
9783805592444
,
1283153556
,
9781283153553
Series Statement:
Else-Kröner-Fresenius-Symposia 1
Content:
There is growing evidence that adult stem cells age. This process can result in alterations in the number and function of stem cells, leading to distinct phenotypic outcomes in different organ systems. This publication provides an outstanding overview of this emerging field.The molecular causes of stem cell aging remain to be defined. Stem cell aging can involve cell-intrinsic as well as cell-extrinsic alterations affecting the stem cell niche or the macroenvironment. Stem cells have a longer life span than other cell populations and retain a capacity to proliferate and differentiate in adult organs. The aging of adult stem cells plays a key role in the decline of organ maintenance and regenerative potential during aging and during the end stage of chronic diseases. In addition, it can contribute to stem cell transformation and carcinogenesis.Molecular Mechanisms of Adult Stem Cell Aging will appeal to scientists working in the fields such as stem cells, aging, regeneration and cancer. This subject matter should be of interest to physicians and scientists specializing in geriatric medicine, internal medicine, and surgery. It is also likely to be an invaluable resource for medical students and biologists who wish to enhance their understanding of molecular and stem cell biology
Note:
A meeting report of the first international Else Kröner-Fresenius-Symposium on Adult Stem Cell Aging
,
""Cover""; ""Contents""; ""Preface""; ""Introduction""; ""Chapter 1: Speakers at the Symposium""; ""Thomas Braun, MD""; ""Tao Cheng, MD""; ""James DeGregori, PhD""; ""Gerald de Haan, PhD""; ""Ronald A. DePinho, MD""; ""Kenneth Dorshkind, PhD""; ""Toren Finkel, MD, PhD""; ""Hartmut Geiger, PhD""; ""Margaret A. Goodell, PhD""; ""D. Leanne Jones, PhD""; ""Zhenyu Ju, MD, PhD""; ""Sean J. Morrison, PhD""; ""Hiromitsu Nakauchi, MD, PhD""; ""Andre Nussenzweig, PhD""; ""Thomas A. Rando, MD, PhD""; ""Tannishtha Reya, PhD""; ""Hans-Reimer Rodewald, PhD""; ""Derrick J. Rossi, PhD""
,
""Karl Lenhard Rudolph, MD""""Norman E. Sharpless, MD""; ""Toshio Suda, MD""; ""Andreas Trumpp, PhD""; ""Maarten van Lohuizen, PhD""; ""Gary Van Zant, PhD""; ""Amy J. Wagers, PhD""; ""Irving L. Weissman, MD""; ""Ting Xie, PhD""; ""Chapter 2: Hematopoietic Stem Cell Aging and Fate Decision""; ""Abstract""; ""Characteristics of Hematopoietic Stem Cells""; ""Functional Changes during Aging""; ""Immuno-Phenotype Changes during Aging""; ""Epigenetic Regulation of Stem Cell Function""; ""DNA Damage Signaling in the Regulation ofHSCs""
,
""Dissecting Age-Dependent Effects on Hematopoiesis in Recombinant Inbred Mouse Strains""""Genes Controlling HSC Quiescence and Self-Renewal""; ""Regulation of Dormant HSCs""; ""Summary""; ""References""; ""Chapter 3: Alterations of Systemic Environment Impair Stem Cell Function during Aging ""; ""Abstract""; ""Introduction""; ""Macroenvironmental Alterations Regulate HSC Function""; ""Macroenvironmental Alterations Regulate SMP Function""; ""Macroenvironmental Aging Characterized by Alterations of Circulatory Factors""
,
""DNA Damage and Telomere Dysfunction Induce Age-Dependent Secretion ofv Circulating Factors""""References""; ""Chapter 4: Novel Insights into Regulation of Stem Cell Aging by Aging of the Niche and Alterations in Systemic Factors""; ""Abstract""; ""Aging of Muscle Stem Cells Is Reversible""; ""Hematopoietic Stem Cells Can Be Rejuvenated by Systemic Factors""; ""Adhesion Is Central to Stem Cell Niche Interactions""; ""Drosophila Germ Line Stem Cells and Their Niche""; ""References""; ""Chapter 5: Aging and Hematopoietic Malignancies ""; ""Abstract""
,
""Loss of Proliferative Capacity of Hematopoietic Cells Can Accelerate Leukemogenesis""""Leukemic Cells Evade the Immune System""; ""Patterns of Cell Divisions in Leukemia""; ""References""; ""Chapter 6: Intestinal Stem Cell Aging ""; ""Abstract""; ""Intestinal Epithelium""; ""Intestinal Stem Cells""; ""Molecular Control of Cell Proliferation and Organ Maintenance in the Intestine""; ""Age-Associated Diseases of the Intestine""; ""Mechanisms of Intestinal Stem Cell Aging in Model Systems""; ""Outlook""; ""References""; ""Chapter 7: Molecular Mechanisms of Aging in Muscle Stem Cells ""
,
""Abstract""
Additional Edition:
ISBN 9783805592437
Additional Edition:
Erscheint auch als Druck-Ausgabe Molecular mechanisms of adult stem cell aging Basel : Karger, 2010 ISBN 9783805592437
Language:
English
Subjects:
Biology
Keywords:
Adulte Stammzelle
;
Altern
;
Telomer
;
Konferenzschrift
Author information:
Rudolph, Karl Lenhard 1969-
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