Kooperativer Bibliotheksverbund

UID:

Format: 1 Online-Ressource (XIV, 273 Seiten) : , Illustrationen, Diagramme.

ISBN: 978-3-318-01254-5

Series Statement: Nestlé nutrition workshop series : Pediatric program Vol. 57

Content: The 57th Nestlé Pediatric Nutrition Workshop assembled a panel of leading international scientists in order to assess and extend the current state of knowledge on the long-term effects of early nutrition. Prevention of diseases, such as obesity, diabetes, cardiovascular disease, osteoporosis, cancer and the metabolic syndrome, by early nutrition intervention is the declared goal of this kind of research.Single papers deal with dietary effects on mental and motor impairment, the epidemical aspects of obesity, the complexity of the relationship between birth weight and adult BMI, the importance for primary prevention in childhood diabetes, the potential of nutritional prevention of osteoporosis, the nutritional key influences on cancer, and the surprising link between cancer and obesity, and many more.Complex, multifaceted and contradictory health outcomes of early nutrition elements clearly show that genetic or environmental interactions have to be taken into account, and compromises have to be found to establish a good balance of risks and benefits for the wide range of different health issues which depend on nutrition and early nutrition in particular

Note: 57th Nestlé Nutrition Workshop, Pediatric Program, Half Moon Bay, San Francisco, Calif., May 2005 ; understanding the interaction of early nutrition and long-term outcome

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-8055-7978-0

Language: English

Subjects: Medicine

Keywords: Kind ; Ernährung ; Primärprävention ; Kind ; Ernährung ; Erwachsener ; Chronische Krankheit ; Prävention ; Konferenzschrift ; Konferenzschrift

DOI: 10.1159/isbn.978-3-318-01254-5

URL: Volltext

UID:

Format: 1 Online-Ressource (XIV, 273 Seiten) : , Illustrationen, Diagramme.

ISBN: 978-3-318-01254-5

Series Statement: Nestlé nutrition workshop series : Pediatric program Vol. 57

Content: The 57th Nestlé Pediatric Nutrition Workshop assembled a panel of leading international scientists in order to assess and extend the current state of knowledge on the long-term effects of early nutrition. Prevention of diseases, such as obesity, diabetes, cardiovascular disease, osteoporosis, cancer and the metabolic syndrome, by early nutrition intervention is the declared goal of this kind of research.Single papers deal with dietary effects on mental and motor impairment, the epidemical aspects of obesity, the complexity of the relationship between birth weight and adult BMI, the importance for primary prevention in childhood diabetes, the potential of nutritional prevention of osteoporosis, the nutritional key influences on cancer, and the surprising link between cancer and obesity, and many more.Complex, multifaceted and contradictory health outcomes of early nutrition elements clearly show that genetic or environmental interactions have to be taken into account, and compromises have to be found to establish a good balance of risks and benefits for the wide range of different health issues which depend on nutrition and early nutrition in particular

Note: 57th Nestlé Nutrition Workshop, Pediatric Program, Half Moon Bay, San Francisco, Calif., May 2005 ; understanding the interaction of early nutrition and long-term outcome

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-8055-7978-0

Language: English

Subjects: Medicine

Keywords: Kind ; Ernährung ; Primärprävention ; Kind ; Ernährung ; Erwachsener ; Chronische Krankheit ; Prävention ; Konferenzschrift ; Konferenzschrift

DOI: 10.1159/isbn.978-3-318-01254-5

URL: Volltext

UID:

Format: 1 Online-Ressource (XIV, 273 Seiten) , Illustrationen, Diagramme

ISBN: 9783318012545

Series Statement: Nestlé nutrition workshop series : Pediatric program Vol. 57

Content: The 57th Nestlé Pediatric Nutrition Workshop assembled a panel of leading international scientists in order to assess and extend the current state of knowledge on the long-term effects of early nutrition. Prevention of diseases, such as obesity, diabetes, cardiovascular disease, osteoporosis, cancer and the metabolic syndrome, by early nutrition intervention is the declared goal of this kind of research.Single papers deal with dietary effects on mental and motor impairment, the epidemical aspects of obesity, the complexity of the relationship between birth weight and adult BMI, the importance for primary prevention in childhood diabetes, the potential of nutritional prevention of osteoporosis, the nutritional key influences on cancer, and the surprising link between cancer and obesity, and many more.Complex, multifaceted and contradictory health outcomes of early nutrition elements clearly show that genetic or environmental interactions have to be taken into account, and compromises have to be found to establish a good balance of risks and benefits for the wide range of different health issues which depend on nutrition and early nutrition in particular

Note: 57th Nestlé Nutrition Workshop, Pediatric Program, Half Moon Bay, San Francisco, Calif., May 2005 ; understanding the interaction of early nutrition and long-term outcome

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-8055-7978-0

Language: English

Subjects: Medicine

Keywords: Kind ; Ernährung ; Primärprävention ; Kind ; Ernährung ; Erwachsener ; Chronische Krankheit ; Prävention ; Konferenzschrift ; Konferenzschrift

DOI: 10.1159/isbn.978-3-318-01254-5

URL: Volltext

UID:

Format: 1 online resource (410 p.)

Edition: 1st ed.

ISBN: 0-12-799930-2

Note: Description based upon print version of record. , Front Cover -- Allergy, Immunity and Tolerance in Early Childhood: The First Steps of the Atopic March -- Copyright -- Contents -- List of Contributors -- Introduction -- 1 - The Maturation of Immune Function in Pregnancy and Early Childhood -- Introduction -- Immune development in health and disease -- Early life immune regulation -- Interplay of innate and adaptive immune regulation in organ-specific responses -- Key influences and determinants of early immune function and regulation -- Genetic factors -- Direct effects of maternal allergy on immune maturation -- Maternal environmental exposures and immune maturation -- Early postnatal exposures and immune maturation -- Modulating early immune development to promote immune regulation -- Conclusion -- References -- 2 - Immunological Aspects of the Atopic March -- Introduction -- Global inventory of the developmental pattern of allergen-specific antibody -- Tentative interpretation of phases observed in the serological picture -- The trends of IgE levels to allergenic sources -- Immunoglobulin E trends examined at a molecular level -- Discussion -- References -- 3 - Atopic Dermatitis in Infancy and Childhood -- Definition -- Family history and genetics -- Natural history of disease -- Allergic sensitization and allergy as comorbidity -- Rhinitis and asthma as comorbidity -- Urticaria as comorbidity -- Determinants of the disease -- Socioeconomic status -- Infant feeding -- Domestic environment -- Key elements of treatment -- Prevention -- Long-term outcome in adulthood -- References -- Further reading -- 4 - Adverse Reactions to Food -- Clinical presentation of food allergy in infancy -- Epidemiology and natural course -- Pathogenesis -- Diagnostic -- Therapy -- Immunotherapy for food allergy -- References -- Further reading -- 5 - Viral-Induced Wheeze and Asthma Development -- Introduction. , Longitudinal studies of childhood wheezing -- Etiology of wheezing illnesses in infancy -- Risk factors for virus-induced wheezing -- Progression from virus-induced wheezing to asthma -- Do severe viral respiratory infections in infancy cause asthma? -- Conclusions -- References -- 6 - Infantile Lung Function and Airway Hyperresponsiveness -- Introduction -- Lung development -- Lung function measurements -- Lung function development -- Postnatal impact on lung function development -- Factors that may influence in utero lung function development -- Infantile AHR -- Summary and conclusion -- References -- 7 - The Development of Allergic Rhinitis in Childhood -- Incidence -- Period prevalence -- Sex differences -- Comorbidity -- The role of sensitization -- Early predictors -- Protective factors -- Principles of therapy -- Options for prevention -- References -- Further reading -- 8 - Genes and Atopic Phenotypes -- Introduction -- Tools for disentangling the genetics of atopy -- Do genes co-associated with multiple childhood atopy phenotypes represent atopic march candidate genes? -- Summary and conclusions -- References -- 9 - Epigenetic Factors Before and After Birth -- Introduction -- Principles of epigenetic mechanisms -- Epigenetics in T-cell development as a decisive mechanism for allergy development -- Epigenetic control in fetal immune development -- Environmental factors and epigenetic modifications in early allergy development -- Allergens as triggers for Th2 responses are associated with epigenetic modifications in target cells -- Microbes in the human environment are capable to protect against allergy development via epigenetic mechanisms -- Airborne, xenobiotic exposures act though epigenetic modulation and enhance early allergic development -- Dietary and metabolic factors are capable to modify epigenetic programs -- Conclusion. , Abbreviations -- References -- 10 - The Physiological Induction of Tolerance to Allergens -- Introduction -- Mechanisms of oral tolerance -- Mechanisms of airway tolerance -- Mechanisms of action of iTreg in mediating oral and airway tolerance -- Early-life exposures can influence immune programming of tolerance -- Summary -- References -- 11 - Microbiome and the Effect on Immune Response -- Introduction -- Coevolutionary interdependency of the microbiome and the immune system -- Microbiome acquisition and development -- Effects of the microbiome on immune development -- Influence of the microbiome on allergy development -- Future perspectives -- References -- 12 - Indoor Allergen Exposure -- Pet exposure -- Preventive measures reducing pet allergen exposure -- House dust mite -- House dust mite avoidance -- Cockroaches -- Molds -- Other allergens -- Summary -- References -- 13 - Microbial Influences on the Development of Atopy -- References -- 14 - Role of Vaccines -- Introduction -- Allergens that may be contained in vaccines -- Allergic immune responses to vaccines -- Immunization and development of allergy -- Considerations for some specific vaccines -- Diphtheria/tetanus/pertussis -- Rotavirus -- Measles, Mumps, and Rubella -- Influenza -- Diagnostic aspects -- Identification of patients at heightened risk -- Immunization of patients at heightened risk -- Conclusion -- References -- 15 - Breast-Always Best? -- Introduction -- Historical aspects -- Challenges with studies -- Evidence for breastfeeding in allergy prevention -- Possible mechanisms by which breastfeeding may protect against allergies -- Use of infant formulas versus breastfeeding -- Human milk immunomodulatory components -- Secretory IgA -- Cytokines, chemokines, and growth factors -- Leukocytes -- Soluble CD14 -- Fatty acids -- Human milk microbiome -- Oligosaccharides -- Exosomes. , Impact of maternal interventions during breastfeeding on prevention of allergy -- Food avoidance diets -- Maternal probiotics, PUFA, vitamins, and antibiotics -- Conclusions -- Abbreviations -- References -- 16 - Dietary Interventions in Infancy -- Introduction -- The gut, the diet, and oral tolerance in early life -- Allergens in the diet: from avoidance toward tolerance induction -- Allergens in the maternal diet -- Allergens in the infant diet -- Immunomodulation via dietary interventions -- Breast milk -- Hydrolysates -- Tolerogenic peptides -- Probiotics -- Prebiotics -- Synbiotics -- Polyunsaturated fatty acids -- Antioxidants -- Conclusion -- Abbreviations -- References -- 17 - Allergen Exposure and Avoidance as Part of Early Intervention and Prevention -- Allergen avoidance -- Allergen exposure, sensitization, and disease -- House dust mite allergen avoidance in primary prevention -- Avoidance of other allergens -- Why environmental allergen avoidance in primary prevention is not effective -- Secondary avoidance -- Studies involving moving patients to a sanatorium or hospital -- Secondary allergen avoidance by making changes in the patient's own home -- References -- 18 - Pharmacotherapies Early in Life to Prevent the Atopic March -- Introduction -- Adverse effects of pharmacotherapies on allergy outcomes -- Paracetamol/Acetaminophen -- Antibiotics -- Acid-suppressive drugs -- Prevention strategies -- Primary prophylaxis agents -- Skin barrier lotions -- Secondary prophylaxis agents -- Antihistamines -- Topical calcineurin inhibitors -- Specific allergen immunotherapy -- Tertiary prophylaxis agents -- Inhaled corticosteroids -- Future therapies -- Conclusions -- References -- 19 - The Role of Antiviral Strategies for the Prevention of Childhood Asthma -- Introduction/Background -- General antiviral strategies to consider. , Lessons learned from antiviral strategies focused on RSV -- Antiviral strategies for rhinovirus -- Specific antivirals -- Interferon and interferon inducers -- Vaccine development -- Other antiviral agents -- Asthma exacerbations provoked by rhinovirus in the atopic population -- Conclusions -- References -- 20 - Prevention of Allergy/Asthma-New Strategies -- Introduction -- Asthma initiation during childhood -- Asthma genetics and environmental risk factors -- Major risk factors for atopic asthma operating during early life -- Timing is crucial -- Plasticity of clinical phenotypes in early life -- Postnatal allergen exposure and risk for allergic disease: is more worse, or better? -- Hidden complexities relating to effects of microbial exposures on atopic disease phenotypes -- Interactions between early infections and aeroallergen sensitization in driving development of allergic disease: atopic asthma a... -- Causal pathways for asthma development in childhood-development of a roadmap for rational design of early intervention strategie... -- Asthma/allergy prevention trials: what can be contemplated now? -- ?Prevention of induction and/or progression of sensitization to aeroallergens -- ?Prevention of respiratory infections during early infancy -- ?Targeting atopic effector pathways for modulation of inflammatory damage associated with viral infections in school-aged atopic... -- ?Pan-specific approaches to protection of infants against viral-induced inflammatory damage of airway tissues -- Possibilities for the near-term future: new therapeutics and repurposing of existing drugs for asthma prevention -- References -- 21 - Antiallergic Strategies: Induction of Tolerance to Food -- Introduction -- Definition of oral tolerance -- Immunological mechanisms of oral tolerance -- Clinical phenotypes of oral tolerance. , Risk and protective factors for food allergy. , English

Additional Edition: ISBN 0-12-420226-8

Language: English

Keywords: Electronic books.

URL: Click to View

UID:

Format: 1 online resource (289 p.)

ISBN: 1-280-51379-9 , 9786610513796 , 1-4294-0253-9 , 3-318-01254-8

Series Statement: Nestle Nutrition workshop series. Pediatric program ; v. 57

Content: The 57th Nestlé Pediatric Nutrition Workshop assembled a panel of leading international scientists in order to assess and extend the current state of knowledge on the long-term effects of early nutrition. Prevention of diseases, such as obesity, diabetes, cardiovascular disease, osteoporosis, cancer and the metabolic syndrome, by early nutrition intervention is the declared goal of this kind of research. Single papers deal with dietary effects on mental and motor impairment, the epidemical aspects of obesity, the complexity of the relationship between birth weight and adult BMI, the importance

Note: "57th Nestle Pediatric Nutrition Workshop, which took place in May 2005 at Half Moon Bay, San Francisco"--Foreword. , Infant nutrition and primary prevention / Lucas, A., Sampson, H.A. -- Nutritional interventions in infancy and childhood for prevention of atherosclerosis and the metabolic syndrome / Singhal, A. -- Childhood obesity / Maffeis, C. -- Prenatal and postnatal development of obesity / Kroke, A. -- Childhood diabetes mellitus with emphasis on perinatal factors / Laron, Z. -- The gut microbiota and potential health effects of intervention / Bjrksten, B. -- The relationship of breastfeeding to the development of atopic disorders / Zeiger, R.S., Friedman, N.J -- Prevention of atopy and allergic disease / Sampson, H.A. -- Introduction of solid foods / Berg, A.V. -- Osteoporosis / Fewtrell, M. -- Nutrition and cancer prevention / Hursting, S.D. ... [et al.] -- Long-chain polyunsaturated fatty acids in early life / Fewtrell, M.S -- Perinatal PUFA intake affects leptin and oral tolerance in neonatal rats and possibly immunoreactivity in intrauterine growth retardation in man / Hanson, L.A. ... [et al.] -- The crucial role of dietary n-6 polyunsaturated fatty acids in excessive adipose tissue development / Massiera, F.; Guesnet, P.; Ailhaud, G. -- Omics for prevention / Affolter, M. ... [et al.]. , English

Additional Edition: ISBN 3-8055-7978-0

Language: English

UID:

Format: 1 online resource (1 volume)

ISBN: 9781118744161 , 1118744160 , 9781118744185 , 1118744187

Uniform Title: Food allergy (John Wiley & Sons, Ltd.)

Note: pt. I. Adverse reactions to food antigens : basic science -- pt. II. Adverse reactions to food antigens : clinical science -- pt. III. Adverse reactions to foods : diagnosis -- pt. IV. Adverse reactions to food additives -- pt. V. Contemporary topics in adverse reactions to foods.

Additional Edition: Print version: Food allergy (John Wiley & Sons, Ltd.). Food allergy ISBN 9780470672556

Language: English

Keywords: Electronic books. ; Electronic books. ; Electronic books.

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781118744185

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781118744185

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781118744185

UID:

Format: 1 online resource

ISBN: 9781118609125 , 1118609123 , 9781118609156 , 1118609158 , 9781118609149 , 111860914X

Series Statement: Mount Sinai expert guides

Content: Contributors, xxx Series foreword, xxx Preface, xxx About the Companion Website, xxx Part 1: Allergy 1 Atopic dermatitis in the infant and young child Jean-Christoph Caubet, Anna Nowak-W©®grzyn 2 Atopic dermatitis in the teenage and adult Saakshi Khattri, Emma Guttman-Yassky 3 Contact Dermatitis Mariya Rozenblit, Emma Guttman-Yassky 4 Allergic rhinitis Supinda Bunyavanich 5 Non-allergic rhinitis Beth E. Corn 6 Sinusitis Yan W Ho, Satish Govindaraj 7 Allergic diseases of the eye Amanda L. Cox 8 Tests for assessing asthma Gwen S. Skloot 9 Asthma in infants and children.

Note: Title Page; Copyright Page; Contents; Contributors; Series Foreword; Preface; List of Abbreviations; About the Companion Website; Part 1 Allergy; Chapter 1 Atopic Dermatitis in Infants and℗ Young℗ Children; Section℗ 1: Background; Section℗ 2: Prevention; Section℗ 3: Diagnosis (Algorithm 1.1); Section℗ 4: Treatment (Algorithm 1.2); Section℗ 5: Special populations; Section℗ 6: Prognosis; Section℗ 7: Reading list; Section℗ 8: Guidelines; Section℗ 9: Evidence; Section℗ 10: Images; Chapter 2 Atopic Dermatitis in Teenagers and Adults; Section℗ 1: Background; Section℗ 2: Prevention. , Section℗ 3: Diagnosis (Algorithm 2.1)Section℗ 4: Treatment (Algorithm 2.2); Section℗ 5: Special populations; Section℗ 6: Prognosis; Section℗ 7: Reading list; Section℗ 8: Guidelines; Section℗ 9: Evidence; Section℗ 10: Images; Chapter 3 Contact Dermatitis; Section℗ 1: Background; Section℗ 2: Prevention; Section℗ 3: Diagnosis (Algorithm 3.1); Section℗ 4: Treatment (Algorithm 3.2); Section℗ 5: Special populations; Section℗ 6: Prognosis; Section℗ 7: Reading list; Section℗ 8: Guidelines; Section℗ 9: Evidence; Section℗ 10: Images; Chapter 4 Allergic Rhinitis; Section℗ 1: Background; Section℗ 2: Prevention. , Section℗ 3: DiagnosisSection℗ 4: Treatment; Section℗ 5: Special populations; Section℗ 6: Prognosis; Section℗ 7: Reading list; Section℗ 8: Guidelines; Section℗ 9: Evidence; Section℗ 10: Images; Chapter 5 Non-Allergic Rhinitis; Section℗ 1: Background; Section℗ 2: Prevention; Section℗ 3: Diagnosis (Algorithm 5.1); Section℗ 4: Treatment; Section℗ 5: Special populations; Section℗ 6: Prognosis; Section℗ 7: Reading list; Section℗ 8: Guidelines; Section℗ 9: Evidence; Section℗ 10: Images; Chapter 6 Sinusitis; Section℗ 1: Background; Section℗ 2: Prevention; Section℗ 3: Diagnosis; Section℗ 4: Treatment. , Section℗ 5: Special populationsSection℗ 6: Prognosis; Section℗ 7: Reading list; Section℗ 8: Guidelines; Section℗ 9: Evidence; Section℗ 10: Images; Chapter 7 Allergic Diseases of the Eye; Section℗ 1: Background; Section℗ 2: Prevention; Section℗ 3: Diagnosis (Algorithm 7.1); Section℗ 4: Treatment (Algorithm 7.2); Section℗ 5: Special populations; Section℗ 6: Prognosis; Section℗ 7: Reading list; Section℗ 8: Guidelines; Section℗ 9: Evidence; Section℗ 10: Images; Chapter 8 Tests for Assessing Asthma; Section℗ 1: Background; Section℗ 2: Prevention; Section℗ 3: Diagnosis; Section℗ 4: Treatment. , Section℗ 5: Special populationsSection℗ 6: Prognosis; Section℗ 7: Reading list; Section℗ 8: Guidelines; Section℗ 9: Evidence; Section℗ 10: Images; Chapter 9 Asthma in Infants and Children; Section℗ 1: Background; Section℗ 2: Prevention; Section 3: Diagnosis; Section℗ 4: Treatment; Section℗ 5: Special populations; Section℗ 6: Prognosis; Section℗ 7: Reading list; Section℗ 8: Guidelines; Section℗ 9: Evidence; Section℗ 10: Images; Chapter 10 Asthma in Teenagers and Adults; Section℗ 1: Background; Section℗ 2: Prevention; Section 3: Diagnosis; Section℗ 4: Treatment; Section℗ 5: Special populations.

Additional Edition: Print version: Mount Sinai expert guides. Chichester, West Sussex ; Hoboken, NJ : John Wiley & Sons Inc., 2015 ISBN 9781118609163

Language: English

Keywords: Electronic books. ; Electronic books. ; Electronic books. ; Electronic books.

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781118609125

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781118609125

URL: Click to View

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781118609125

UID:

Format: 1 Online-Ressource (XIV, 273 Seiten) : , Illustrationen, Diagramme.

ISBN: 978-3-318-01254-5

Series Statement: Nestlé nutrition workshop series : Pediatric program Vol. 57

Content: The 57th Nestlé Pediatric Nutrition Workshop assembled a panel of leading international scientists in order to assess and extend the current state of knowledge on the long-term effects of early nutrition. Prevention of diseases, such as obesity, diabetes, cardiovascular disease, osteoporosis, cancer and the metabolic syndrome, by early nutrition intervention is the declared goal of this kind of research.Single papers deal with dietary effects on mental and motor impairment, the epidemical aspects of obesity, the complexity of the relationship between birth weight and adult BMI, the importance for primary prevention in childhood diabetes, the potential of nutritional prevention of osteoporosis, the nutritional key influences on cancer, and the surprising link between cancer and obesity, and many more.Complex, multifaceted and contradictory health outcomes of early nutrition elements clearly show that genetic or environmental interactions have to be taken into account, and compromises have to be found to establish a good balance of risks and benefits for the wide range of different health issues which depend on nutrition and early nutrition in particular

Note: 57th Nestlé Nutrition Workshop, Pediatric Program, Half Moon Bay, San Francisco, Calif., May 2005 ; understanding the interaction of early nutrition and long-term outcome

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-8055-7978-0

Language: English

Subjects: Medicine

Keywords: Kind ; Ernährung ; Primärprävention ; Kind ; Ernährung ; Erwachsener ; Chronische Krankheit ; Prävention ; Konferenzschrift ; Konferenzschrift

DOI: 10.1159/isbn.978-3-318-01254-5

URL: Volltext

UID:

Format: 1 online resource (410 p.)

Edition: 1st ed.

ISBN: 0-12-799930-2

Note: Description based upon print version of record. , Front Cover -- Allergy, Immunity and Tolerance in Early Childhood: The First Steps of the Atopic March -- Copyright -- Contents -- List of Contributors -- Introduction -- 1 - The Maturation of Immune Function in Pregnancy and Early Childhood -- Introduction -- Immune development in health and disease -- Early life immune regulation -- Interplay of innate and adaptive immune regulation in organ-specific responses -- Key influences and determinants of early immune function and regulation -- Genetic factors -- Direct effects of maternal allergy on immune maturation -- Maternal environmental exposures and immune maturation -- Early postnatal exposures and immune maturation -- Modulating early immune development to promote immune regulation -- Conclusion -- References -- 2 - Immunological Aspects of the Atopic March -- Introduction -- Global inventory of the developmental pattern of allergen-specific antibody -- Tentative interpretation of phases observed in the serological picture -- The trends of IgE levels to allergenic sources -- Immunoglobulin E trends examined at a molecular level -- Discussion -- References -- 3 - Atopic Dermatitis in Infancy and Childhood -- Definition -- Family history and genetics -- Natural history of disease -- Allergic sensitization and allergy as comorbidity -- Rhinitis and asthma as comorbidity -- Urticaria as comorbidity -- Determinants of the disease -- Socioeconomic status -- Infant feeding -- Domestic environment -- Key elements of treatment -- Prevention -- Long-term outcome in adulthood -- References -- Further reading -- 4 - Adverse Reactions to Food -- Clinical presentation of food allergy in infancy -- Epidemiology and natural course -- Pathogenesis -- Diagnostic -- Therapy -- Immunotherapy for food allergy -- References -- Further reading -- 5 - Viral-Induced Wheeze and Asthma Development -- Introduction. , Longitudinal studies of childhood wheezing -- Etiology of wheezing illnesses in infancy -- Risk factors for virus-induced wheezing -- Progression from virus-induced wheezing to asthma -- Do severe viral respiratory infections in infancy cause asthma? -- Conclusions -- References -- 6 - Infantile Lung Function and Airway Hyperresponsiveness -- Introduction -- Lung development -- Lung function measurements -- Lung function development -- Postnatal impact on lung function development -- Factors that may influence in utero lung function development -- Infantile AHR -- Summary and conclusion -- References -- 7 - The Development of Allergic Rhinitis in Childhood -- Incidence -- Period prevalence -- Sex differences -- Comorbidity -- The role of sensitization -- Early predictors -- Protective factors -- Principles of therapy -- Options for prevention -- References -- Further reading -- 8 - Genes and Atopic Phenotypes -- Introduction -- Tools for disentangling the genetics of atopy -- Do genes co-associated with multiple childhood atopy phenotypes represent atopic march candidate genes? -- Summary and conclusions -- References -- 9 - Epigenetic Factors Before and After Birth -- Introduction -- Principles of epigenetic mechanisms -- Epigenetics in T-cell development as a decisive mechanism for allergy development -- Epigenetic control in fetal immune development -- Environmental factors and epigenetic modifications in early allergy development -- Allergens as triggers for Th2 responses are associated with epigenetic modifications in target cells -- Microbes in the human environment are capable to protect against allergy development via epigenetic mechanisms -- Airborne, xenobiotic exposures act though epigenetic modulation and enhance early allergic development -- Dietary and metabolic factors are capable to modify epigenetic programs -- Conclusion. , Abbreviations -- References -- 10 - The Physiological Induction of Tolerance to Allergens -- Introduction -- Mechanisms of oral tolerance -- Mechanisms of airway tolerance -- Mechanisms of action of iTreg in mediating oral and airway tolerance -- Early-life exposures can influence immune programming of tolerance -- Summary -- References -- 11 - Microbiome and the Effect on Immune Response -- Introduction -- Coevolutionary interdependency of the microbiome and the immune system -- Microbiome acquisition and development -- Effects of the microbiome on immune development -- Influence of the microbiome on allergy development -- Future perspectives -- References -- 12 - Indoor Allergen Exposure -- Pet exposure -- Preventive measures reducing pet allergen exposure -- House dust mite -- House dust mite avoidance -- Cockroaches -- Molds -- Other allergens -- Summary -- References -- 13 - Microbial Influences on the Development of Atopy -- References -- 14 - Role of Vaccines -- Introduction -- Allergens that may be contained in vaccines -- Allergic immune responses to vaccines -- Immunization and development of allergy -- Considerations for some specific vaccines -- Diphtheria/tetanus/pertussis -- Rotavirus -- Measles, Mumps, and Rubella -- Influenza -- Diagnostic aspects -- Identification of patients at heightened risk -- Immunization of patients at heightened risk -- Conclusion -- References -- 15 - Breast-Always Best? -- Introduction -- Historical aspects -- Challenges with studies -- Evidence for breastfeeding in allergy prevention -- Possible mechanisms by which breastfeeding may protect against allergies -- Use of infant formulas versus breastfeeding -- Human milk immunomodulatory components -- Secretory IgA -- Cytokines, chemokines, and growth factors -- Leukocytes -- Soluble CD14 -- Fatty acids -- Human milk microbiome -- Oligosaccharides -- Exosomes. , Impact of maternal interventions during breastfeeding on prevention of allergy -- Food avoidance diets -- Maternal probiotics, PUFA, vitamins, and antibiotics -- Conclusions -- Abbreviations -- References -- 16 - Dietary Interventions in Infancy -- Introduction -- The gut, the diet, and oral tolerance in early life -- Allergens in the diet: from avoidance toward tolerance induction -- Allergens in the maternal diet -- Allergens in the infant diet -- Immunomodulation via dietary interventions -- Breast milk -- Hydrolysates -- Tolerogenic peptides -- Probiotics -- Prebiotics -- Synbiotics -- Polyunsaturated fatty acids -- Antioxidants -- Conclusion -- Abbreviations -- References -- 17 - Allergen Exposure and Avoidance as Part of Early Intervention and Prevention -- Allergen avoidance -- Allergen exposure, sensitization, and disease -- House dust mite allergen avoidance in primary prevention -- Avoidance of other allergens -- Why environmental allergen avoidance in primary prevention is not effective -- Secondary avoidance -- Studies involving moving patients to a sanatorium or hospital -- Secondary allergen avoidance by making changes in the patient's own home -- References -- 18 - Pharmacotherapies Early in Life to Prevent the Atopic March -- Introduction -- Adverse effects of pharmacotherapies on allergy outcomes -- Paracetamol/Acetaminophen -- Antibiotics -- Acid-suppressive drugs -- Prevention strategies -- Primary prophylaxis agents -- Skin barrier lotions -- Secondary prophylaxis agents -- Antihistamines -- Topical calcineurin inhibitors -- Specific allergen immunotherapy -- Tertiary prophylaxis agents -- Inhaled corticosteroids -- Future therapies -- Conclusions -- References -- 19 - The Role of Antiviral Strategies for the Prevention of Childhood Asthma -- Introduction/Background -- General antiviral strategies to consider. , Lessons learned from antiviral strategies focused on RSV -- Antiviral strategies for rhinovirus -- Specific antivirals -- Interferon and interferon inducers -- Vaccine development -- Other antiviral agents -- Asthma exacerbations provoked by rhinovirus in the atopic population -- Conclusions -- References -- 20 - Prevention of Allergy/Asthma-New Strategies -- Introduction -- Asthma initiation during childhood -- Asthma genetics and environmental risk factors -- Major risk factors for atopic asthma operating during early life -- Timing is crucial -- Plasticity of clinical phenotypes in early life -- Postnatal allergen exposure and risk for allergic disease: is more worse, or better? -- Hidden complexities relating to effects of microbial exposures on atopic disease phenotypes -- Interactions between early infections and aeroallergen sensitization in driving development of allergic disease: atopic asthma a... -- Causal pathways for asthma development in childhood-development of a roadmap for rational design of early intervention strategie... -- Asthma/allergy prevention trials: what can be contemplated now? -- ?Prevention of induction and/or progression of sensitization to aeroallergens -- ?Prevention of respiratory infections during early infancy -- ?Targeting atopic effector pathways for modulation of inflammatory damage associated with viral infections in school-aged atopic... -- ?Pan-specific approaches to protection of infants against viral-induced inflammatory damage of airway tissues -- Possibilities for the near-term future: new therapeutics and repurposing of existing drugs for asthma prevention -- References -- 21 - Antiallergic Strategies: Induction of Tolerance to Food -- Introduction -- Definition of oral tolerance -- Immunological mechanisms of oral tolerance -- Clinical phenotypes of oral tolerance. , Risk and protective factors for food allergy. , English

Additional Edition: ISBN 0-12-420226-8

Language: English

UID:

Format: 1 online resource (410 p.)

Edition: 1st ed.

ISBN: 0-12-799930-2

Note: Description based upon print version of record. , Front Cover -- Allergy, Immunity and Tolerance in Early Childhood: The First Steps of the Atopic March -- Copyright -- Contents -- List of Contributors -- Introduction -- 1 - The Maturation of Immune Function in Pregnancy and Early Childhood -- Introduction -- Immune development in health and disease -- Early life immune regulation -- Interplay of innate and adaptive immune regulation in organ-specific responses -- Key influences and determinants of early immune function and regulation -- Genetic factors -- Direct effects of maternal allergy on immune maturation -- Maternal environmental exposures and immune maturation -- Early postnatal exposures and immune maturation -- Modulating early immune development to promote immune regulation -- Conclusion -- References -- 2 - Immunological Aspects of the Atopic March -- Introduction -- Global inventory of the developmental pattern of allergen-specific antibody -- Tentative interpretation of phases observed in the serological picture -- The trends of IgE levels to allergenic sources -- Immunoglobulin E trends examined at a molecular level -- Discussion -- References -- 3 - Atopic Dermatitis in Infancy and Childhood -- Definition -- Family history and genetics -- Natural history of disease -- Allergic sensitization and allergy as comorbidity -- Rhinitis and asthma as comorbidity -- Urticaria as comorbidity -- Determinants of the disease -- Socioeconomic status -- Infant feeding -- Domestic environment -- Key elements of treatment -- Prevention -- Long-term outcome in adulthood -- References -- Further reading -- 4 - Adverse Reactions to Food -- Clinical presentation of food allergy in infancy -- Epidemiology and natural course -- Pathogenesis -- Diagnostic -- Therapy -- Immunotherapy for food allergy -- References -- Further reading -- 5 - Viral-Induced Wheeze and Asthma Development -- Introduction. , Longitudinal studies of childhood wheezing -- Etiology of wheezing illnesses in infancy -- Risk factors for virus-induced wheezing -- Progression from virus-induced wheezing to asthma -- Do severe viral respiratory infections in infancy cause asthma? -- Conclusions -- References -- 6 - Infantile Lung Function and Airway Hyperresponsiveness -- Introduction -- Lung development -- Lung function measurements -- Lung function development -- Postnatal impact on lung function development -- Factors that may influence in utero lung function development -- Infantile AHR -- Summary and conclusion -- References -- 7 - The Development of Allergic Rhinitis in Childhood -- Incidence -- Period prevalence -- Sex differences -- Comorbidity -- The role of sensitization -- Early predictors -- Protective factors -- Principles of therapy -- Options for prevention -- References -- Further reading -- 8 - Genes and Atopic Phenotypes -- Introduction -- Tools for disentangling the genetics of atopy -- Do genes co-associated with multiple childhood atopy phenotypes represent atopic march candidate genes? -- Summary and conclusions -- References -- 9 - Epigenetic Factors Before and After Birth -- Introduction -- Principles of epigenetic mechanisms -- Epigenetics in T-cell development as a decisive mechanism for allergy development -- Epigenetic control in fetal immune development -- Environmental factors and epigenetic modifications in early allergy development -- Allergens as triggers for Th2 responses are associated with epigenetic modifications in target cells -- Microbes in the human environment are capable to protect against allergy development via epigenetic mechanisms -- Airborne, xenobiotic exposures act though epigenetic modulation and enhance early allergic development -- Dietary and metabolic factors are capable to modify epigenetic programs -- Conclusion. , Abbreviations -- References -- 10 - The Physiological Induction of Tolerance to Allergens -- Introduction -- Mechanisms of oral tolerance -- Mechanisms of airway tolerance -- Mechanisms of action of iTreg in mediating oral and airway tolerance -- Early-life exposures can influence immune programming of tolerance -- Summary -- References -- 11 - Microbiome and the Effect on Immune Response -- Introduction -- Coevolutionary interdependency of the microbiome and the immune system -- Microbiome acquisition and development -- Effects of the microbiome on immune development -- Influence of the microbiome on allergy development -- Future perspectives -- References -- 12 - Indoor Allergen Exposure -- Pet exposure -- Preventive measures reducing pet allergen exposure -- House dust mite -- House dust mite avoidance -- Cockroaches -- Molds -- Other allergens -- Summary -- References -- 13 - Microbial Influences on the Development of Atopy -- References -- 14 - Role of Vaccines -- Introduction -- Allergens that may be contained in vaccines -- Allergic immune responses to vaccines -- Immunization and development of allergy -- Considerations for some specific vaccines -- Diphtheria/tetanus/pertussis -- Rotavirus -- Measles, Mumps, and Rubella -- Influenza -- Diagnostic aspects -- Identification of patients at heightened risk -- Immunization of patients at heightened risk -- Conclusion -- References -- 15 - Breast-Always Best? -- Introduction -- Historical aspects -- Challenges with studies -- Evidence for breastfeeding in allergy prevention -- Possible mechanisms by which breastfeeding may protect against allergies -- Use of infant formulas versus breastfeeding -- Human milk immunomodulatory components -- Secretory IgA -- Cytokines, chemokines, and growth factors -- Leukocytes -- Soluble CD14 -- Fatty acids -- Human milk microbiome -- Oligosaccharides -- Exosomes. , Impact of maternal interventions during breastfeeding on prevention of allergy -- Food avoidance diets -- Maternal probiotics, PUFA, vitamins, and antibiotics -- Conclusions -- Abbreviations -- References -- 16 - Dietary Interventions in Infancy -- Introduction -- The gut, the diet, and oral tolerance in early life -- Allergens in the diet: from avoidance toward tolerance induction -- Allergens in the maternal diet -- Allergens in the infant diet -- Immunomodulation via dietary interventions -- Breast milk -- Hydrolysates -- Tolerogenic peptides -- Probiotics -- Prebiotics -- Synbiotics -- Polyunsaturated fatty acids -- Antioxidants -- Conclusion -- Abbreviations -- References -- 17 - Allergen Exposure and Avoidance as Part of Early Intervention and Prevention -- Allergen avoidance -- Allergen exposure, sensitization, and disease -- House dust mite allergen avoidance in primary prevention -- Avoidance of other allergens -- Why environmental allergen avoidance in primary prevention is not effective -- Secondary avoidance -- Studies involving moving patients to a sanatorium or hospital -- Secondary allergen avoidance by making changes in the patient's own home -- References -- 18 - Pharmacotherapies Early in Life to Prevent the Atopic March -- Introduction -- Adverse effects of pharmacotherapies on allergy outcomes -- Paracetamol/Acetaminophen -- Antibiotics -- Acid-suppressive drugs -- Prevention strategies -- Primary prophylaxis agents -- Skin barrier lotions -- Secondary prophylaxis agents -- Antihistamines -- Topical calcineurin inhibitors -- Specific allergen immunotherapy -- Tertiary prophylaxis agents -- Inhaled corticosteroids -- Future therapies -- Conclusions -- References -- 19 - The Role of Antiviral Strategies for the Prevention of Childhood Asthma -- Introduction/Background -- General antiviral strategies to consider. , Lessons learned from antiviral strategies focused on RSV -- Antiviral strategies for rhinovirus -- Specific antivirals -- Interferon and interferon inducers -- Vaccine development -- Other antiviral agents -- Asthma exacerbations provoked by rhinovirus in the atopic population -- Conclusions -- References -- 20 - Prevention of Allergy/Asthma-New Strategies -- Introduction -- Asthma initiation during childhood -- Asthma genetics and environmental risk factors -- Major risk factors for atopic asthma operating during early life -- Timing is crucial -- Plasticity of clinical phenotypes in early life -- Postnatal allergen exposure and risk for allergic disease: is more worse, or better? -- Hidden complexities relating to effects of microbial exposures on atopic disease phenotypes -- Interactions between early infections and aeroallergen sensitization in driving development of allergic disease: atopic asthma a... -- Causal pathways for asthma development in childhood-development of a roadmap for rational design of early intervention strategie... -- Asthma/allergy prevention trials: what can be contemplated now? -- ?Prevention of induction and/or progression of sensitization to aeroallergens -- ?Prevention of respiratory infections during early infancy -- ?Targeting atopic effector pathways for modulation of inflammatory damage associated with viral infections in school-aged atopic... -- ?Pan-specific approaches to protection of infants against viral-induced inflammatory damage of airway tissues -- Possibilities for the near-term future: new therapeutics and repurposing of existing drugs for asthma prevention -- References -- 21 - Antiallergic Strategies: Induction of Tolerance to Food -- Introduction -- Definition of oral tolerance -- Immunological mechanisms of oral tolerance -- Clinical phenotypes of oral tolerance. , Risk and protective factors for food allergy. , English

Additional Edition: ISBN 0-12-420226-8

Language: English