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Trace elements, ageing, and sex : impact on genome stability maintenance (2021)

Wandt, Victoria Klara Veronika [VerfasserIn] ; Schwerdtle, Tanja [AkademischeR BetreuerIn] 1975- ; Haase, Hajo [AkademischeR BetreuerIn] 1973- ; [et al.]

Potsdam

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UID:

gbv_1786854139

Format: XVI, 204, iii Seiten , Illustrationen, Diagramme

Note: kumulative Dissertation , Dissertation Universität Potsdam 2021

Language: English

Keywords: Hochschulschrift

Author information: Haase, Hajo 1973-

Author information: Schwerdtle, Tanja 1975-

Author information: Klotz, Lars-Oliver 1969-

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Development of LC-MS/MS multi-methods for the analysis of contaminants and residues (2021)

Rausch, Ann-Kristin [VerfasserIn] ; Schwerdtle, Tanja [AkademischeR BetreuerIn] 1975- ; Humpf, Hans-Ulrich [AkademischeR BetreuerIn] 1966- ; [et al.]

Potsdam

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UID:

gbv_1772128554

Format: IX, 234, v Seiten , Illustrationen, Diagramme

Content: Mycotoxins are secondary metabolites produced by several filamentous fungal species, thus occurring ubiquitously in the environment and food. While the heterogeneous group shows differences in their bioavailability and toxicity, the low-molecular-weight xenobiotics are capable of impacting human and animal health acutely and chronically. Therefore, maximum levels for the major mycotoxins in food and feed are regulated in the current European legislation. Besides free mycotoxins, naturally occurring modified mycotoxins are gaining more attention in recent years. Modified mycotoxins constitute toxins altered by plants, microorganisms, and living organisms in different metabolic pathways or food processing steps. The toxicological relevant compounds often co-occur with their free forms in infested food and feed. Thus, the toxins may contribute to the overall toxicity of mycotoxins, wherefore their presence and toxicity should be considered in risk assessment. [...]

Note: Kumulative Dissertation , Dissertation Universität Potsdam 2021

Language: English

Keywords: Mykotoxin ; LC-MS ; Tandem-Massenspektrometrie ; Hochschulschrift

URL: Inhaltsverzeichnis

Author information: Humpf, Hans-Ulrich 1966-

Author information: Schwerdtle, Tanja 1975-

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Toxicological characterization of arsenolipids in vitro and analysis of global DNA (Hydroxy)methylation in the context of aging, trace element status, and genomic stability (2020)

Finke, Hannah [VerfasserIn] ; Schwerdtle, Tanja [AkademischeR BetreuerIn] 1975- ; Kleuser, Burkhard [AkademischeR BetreuerIn] 1964- ; [et al.]

Potsdam

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UID:

gbv_1742335268

Format: 1 Band (verschiedene Seitenzählungen) , Illustrationen, Diagramme

Note: kumulative Dissertation , Dissertation Universität Potsdam 2020

Language: English

Keywords: Hochschulschrift

Author information: Schwerdtle, Tanja 1975-

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Entwicklung eines Lebensmitteluntersuchungssystems für mikrobielle Erreger mit Hilfe molekularbiologischer Methoden (2020)

Haferkorn-Starke, Robert Christian [VerfasserIn] 1983- ; Schwerdtle, Tanja [AkademischeR BetreuerIn] 1975- ; Kleuser, Burkhard [AkademischeR BetreuerIn] 1964- ; [et al.]

Potsdam

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UID:

gbv_1754877710

Format: XVII, 239, vi Seiten , Illustrationen, Diagramme

Note: Dissertation Universität Potsdam 2021

Language: German

Keywords: Hochschulschrift ; Dissertation ; Hochschulschrift

Author information: Schwerdtle, Tanja 1975-

Author information: Brockmeyer, Jens 1974-

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Toxische Effekte von Arsenolipiden in humanen Kulturzellen und Caenorhabditis elegans (2019)

Ziemann, Vanessa [VerfasserIn] ; Schwerdtle, Tanja [AkademischeR BetreuerIn] 1975- ; Kleuser, Burkhard [AkademischeR BetreuerIn] 1964- ; [et al.]

Potsdam

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UID:

gbv_1700462091

Format: X, 112 Seiten

Note: Dissertation Universität Potsdam 2020

Language: German

Keywords: Hochschulschrift

Author information: Haase, Hajo 1973-

Author information: Schwerdtle, Tanja 1975-

Author information: Ziemann, Vanessa

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Toxic or beneficial? : What is the role of food-relevant selenium species selenoneine? (2022)

Drobyshev, Evgenii [VerfasserIn] [VerfasserIn] ; Schwerdtle, Tanja [AkademischeR BetreuerIn] 1975- ; Kleuser, Burkhard [AkademischeR BetreuerIn] 1964- ; [et al.]

Potsdam

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UID:

gbv_1842789740

Format: xiv, 100 Seiten , Illustrationen, Diagramme

Content: Selenium (Se) is an essential trace element that is ubiquitously present in the environment in small concentrations. Essential functions of Se in the human body are manifested through the wide range of proteins, containing selenocysteine as their active center. Such proteins are called selenoproteins which are found in multiple physiological processes like antioxidative defense and the regulation of thyroid hormone functions. Therefore, Se deficiency is known to cause a broad spectrum of physiological impairments, especially in endemic regions with low Se content. Nevertheless, being an essential trace element, Se could exhibit toxic effects, if its intake exceeds tolerable levels. Accordingly, this range between deficiency and overexposure represents optimal Se supply. However, this range was found to be narrower than for any other essential trace element. Together with significantly varying Se concentrations in soil and the presence of specific bioaccumulation factors, this represents a noticeable difficulty in the assessment of Se ...

Note: Dissertation Universität Potsdam 2022

Additional Edition: Erscheint auch als Online-Ausgabe Drobyshev, Evgenii Toxic or beneficial? Potsdam, 2022

Language: English

Keywords: Hochschulschrift

Author information: Schwerdtle, Tanja 1975-

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Role of proteolytic systems in lipotoxicity - induced hepatocellular damage (2021)

Korovila, Ioanna [VerfasserIn] ; Grune, Tilman [AkademischeR BetreuerIn] 1962- ; Schwerdtle, Tanja [AkademischeR BetreuerIn] 1975- ; [et al.]

Potsdam

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UID:

gbv_1816758388

Format: 115 Seiten , Illustrationen, Diagramme

Content: Scope: Several studies show that excessive lipid intake can cause hepatic steatosis. To investigate lipotoxicity on cellular level, palmitate (PA) is often used to highly increase lipid droplets (LDs). One way to remove LDs is autophagy, while it is controversially discussed if autophagy is also affected by PA. It is aimed to investigate whether PA-induced LD accumulation can impair autophagy and punicalagin, a natural autophagy inducer from pomegranate, can improve it. Methods and results: To verify the role of autophagy in LD degradation, HepG2 cells are treated with PA and analyzed for LD and perilipin 2 content in presence of autophagy inducer Torin 1 and inhibitor 3-Methyladenine. PA alone seems to initially induce autophagy-related proteins but impairs autophagic-flux in a time-dependent manner, considering 6 and 24 h PA. To examine whether punicalagin can prevent autophagy impairment, cells are cotreated for 24 h with PA and punicalagin. Results show that punicalagin preserves expression of autophagy-related proteins and ...

Note: Dissertation Universität Potsdam 2022

Additional Edition: Erscheint auch als Online-Ausgabe Korovila, Ioanna Role of proteolytic systems in lipotoxicity - induced hepatocellular damage Potsdam, 2021

Language: English

Keywords: Hochschulschrift

Author information: Schwerdtle, Tanja 1975-

Author information: Grune, Tilman 1962-

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In vitro Toxizität von Elektrolytlösungen der Lithium-Ionen Batterie (2016)

Weber, Florian Till [VerfasserIn] ; Schwerdtle, Tanja [AkademischeR BetreuerIn] 1975- ; Universität Potsdam

Potsdam

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UID:

gbv_859273350

Format: XII, 119, vii Seiten , Illustrationen, Diagramme , 30 cm

Note: Dissertation Universität Potsdam 2016

Language: German

Keywords: Lithium-Ionen-Akkumulator ; Toxizität ; Hochschulschrift

URL: Inhaltsverzeichnis

Author information: Schwerdtle, Tanja 1975-

Author information: Weber, Florian Till

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Untersuchung der molekularen Toxizität von Pyrrolizidinalkaloiden in der humanen Hepatomzelllinie HepaRG : strukturbedingte Effekte nach einmaliger und wiederholter Exposition (2018)

Waizenegger, Julia [VerfasserIn] ; Schwerdtle, Tanja [GutachterIn] 1975-

Potsdam

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UID:

gbv_1031755500

Format: IX, 129, X-XLI Seiten , Illustrationen, Diagramme

Note: Dissertation Universität Potsdam 2018

Language: German

Keywords: Hochschulschrift

Author information: Schwerdtle, Tanja 1975-

Author information: Waizenegger, Julia

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Funktion von Selenoproteinen  während der kolorektalen Karzinogenese (2018)

Bertz, Martin [VerfasserIn] ; Grune, Tilman [AkademischeR BetreuerIn] 1962- ; Kipp, Anna [AkademischeR BetreuerIn] ; [et al.]

Potsdam

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UID:

gbv_1737864479

Format: 1 Online-Ressource (VII, 109 Blätter, 3000 KB) , Illustrationen, Diagramme

Content: Kolorektalkrebs (CRC) ist die dritthäufigste Tumorerkrankung weltweit. Neben dem Alter spielt auch die Ernährung eine wichtige Rolle bei der Entstehung der Krankheit. Eine vermutlich krebspräventive Wirkung wird dabei dem Spurenelement Selen zugeschrieben, das fast ausschließlich über Lebensmittel aufgenommen wird. So hängt beispielsweise ein niedriger Selenstatus mit dem Risiko, im Laufe des Lebens an CRC zu erkranken, zusammen. Seine Funktionen vermittelt Selen dabei überwiegend durch Selenoproteine, in denen es in Form von Selenocystein eingebaut wird. Zu den bisher am besten untersuchten Selenoproteinen mit möglicher Funktion während CRC zählen die Glutathionperoxidasen (GPXen). Die Mitglieder dieser Familie tragen aufgrund ihrer Hydroperoxid-reduzierenden Eigenschaften entscheidend zum Schutz der Zellen vor oxidativem Stress bei. Dies kann je nach Art und Stadium des Tumors entweder krebshemmend oder -fördernd wirken, da auch transformierte Zellen von dieser Schutzfunktion profitieren. In dieser Arbeit wurde die GPX2 in ...

Note: Dissertation Universität Potsdam 2019

Additional Edition: Erscheint auch als Druck-Ausgabe Bertz, Martin Funktion von Selenoproteinen während der kolorektalen Karzinogenese Potsdam, 2018

Language: German

Keywords: Hochschulschrift

DOI: 10.25932/publishup-42780

URN: urn:nbn:de:kobv:517-opus4-427808

URL: https://nbn-resolving.org/urn:nbn:de:kobv:517-opus4-427808

URL: https://d-nb.info/1219149977/34

URL: kostenfrei

Author information: Frank, Jan

Author information: Schwerdtle, Tanja 1975-

Author information: Grune, Tilman 1962-

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Open Access Request

UB Potsdam

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