Kooperativer Bibliotheksverbund

UID:

Format: 1 Online-Ressource (Approx. 1200 p. 540 illus., 240 illus. in color).

ISBN: 978-4-431-54836-2

Language: English

DOI: 10.1007/978-4-431-54836-2

URL: Volltext  (URL des Erstveröffentlichers)

URL: Volltext  (URL des Erstveröffentlichers)

URL: lizenzpflichtig

URL: https://doi.org/10.1007/978-4-431-54836-2

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Format: XIV, 240 S. , Ill., graph. Darst. , 22 cm

ISBN: 3540708480 , 9783540708483

Series Statement: Ernst Schering Research Foundation symposium proceedings 2006-3

Note: Literaturangaben

Additional Edition: Erscheint auch als Online-Ausgabe Seeberger, P.H. New Avenues to Efficient Chemical Synthesis Berlin, Heidelberg : Springer-Verlag Berlin Heidelberg, 2007 ISBN 9783540708490

Language: English

Subjects: Chemistry/Pharmacy

Keywords: Arzneimittel ; Chemische Synthese ; Aufsatzsammlung ; Konferenzschrift ; Aufsatzsammlung ; Aufsatzsammlung

URL: Inhaltsverzeichnis

URL: Inhaltstext

URL: Cover

UID:

Format: Online-Ressource (200 p) , 200 b&w, halftones

Edition: RSC eBook Collection 1968-2009

ISBN: 1847559735 , 9781847559739

Series Statement: RSC Green chemistry v. 5

Content: Summarises new trends in organic synthesis, based on flow continuous processes, mini- and micro-reactors, homogeneous and heterogeneous catalysts and reagents, Pharmaceutical and fine chemical products are typically synthesised batchwise which is an anomaly since batch processes have a series of practical and economical disadvantages. On the contrary, flow continuous processes present a series of advantages leading to new ways to synthesise chemical products. Flow processes - * enable control reaction parameters more precisely (temperature, residence time, amount of reagents and solvent etc.) , leading to better reproducibility, safer and more reliable processes * can be performed more advantageously using immobilized reagents or catalysts * improve the selectivity and productivity of the process and possibly even the stability of the catalyst * offer opportunities for heat exchange and energy conservation as well as an easy separation and recycling of the reactants and products by adequate process design * achieve multistep syntheses by assembling a line of reactors with minimum or no purification in between two reaction steps * can be assured by facile automation * scale-up can be easily conducted by number-up With all the new research activity in manufacturing chemical products, this comprehensive book is very timely, as it summarises the latest trends in organic synthesis. It gives an insight into flow continuous processes, outlining the basic concepts and explaining the terminology of, and systems approach to, process design dealing with both homogeneous and heterogeneous catalysis and mini- or micro-reactors. The book contains case studies, extensive bibliographies and reference lists in each chapter to enable the reader to grasp the contents and to go on to more detailed texts on specific subjects if desired. The book is written by both organic chemists and engineers giving a multidisciplinary vision of the new tools and methodologies in this field. It is essential reading for organic chemists (in industry or academia) working alongside chemical engineers or who want to undertake chemical engineering projects. It will also be of interest for chemical engineers to see how basic engineering concepts are applied in modern organic chemistry

Note: Ebook , Epublication based on: 9780854041923 , Functional Organic Materials for the development of efficient Flow-Through processes. Zeolites and related Materials for Developing Continuous Flow Systems. Microfluidic devices Engineering factors for efficient Flow processes Flow Processes in non-conventional media On-line monitoring Flow Processes. An industrial perspective.

Language: English

URL: Volltext  (Deutschlandweit zugänglich)

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Format: XII, 308 S. : Ill., graph. Darst.

ISBN: 0-471-37828-3

Language: English

Subjects: Chemistry/Pharmacy

Keywords: Glykokonjugate ; Kombinatorische Synthese ; Festphasentechnik ; Oligosaccharide ; Kombinatorische Synthese ; Festphasentechnik ; Aufsatzsammlung

URL: Autorenbiografie

URL: Verlagsangaben

URL: Cover

URL: http://www.loc.gov/catdir/toc/onix07/2001023796.html

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Format: 1 online resource (253 p.)

Edition: 1st ed. 2007.

ISBN: 1-280-94091-3 , 9786610940912 , 3-540-70849-9

Series Statement: Ernst Schering Research Foundation symposium proceedings, 2006-3

Content: In modern drug discovery and development, chemical synthesis is one of the key technologies. For the rapid preparation of new test compounds and drug development candidates, several innovative technologies with great potential have emerged: Microreactor chemistry; Nanotechnology and catalysis research; Microwave-assisted organic synthesis; New developments in solid supported synthesis. This book covers lectures about the theory, use, scope and limitations of these new technologies in chemical synthesis. It provides a useful overview for scientists in the pharmaceutical industry as well as in academic institutions interested in chemical synthesis for drug discovery and development.

Note: Description based upon print version of record. , Microreactors as Tools in the Hands of Synthetic Chemists -- Micro-Fluidic and Lab-on-a-Chip Technology -- Microreactors as New Tools for Drug Discovery and Development -- Microchemical Systems for Discovery and Development -- Isoindolones and Related N-Heterocycles Isoindolones and Related N-Heterocycles via Palladium Nanoparticle-Catalyzed 3-Component Cascade Reactions -- Applying Homogeneous Catalysis for the Synthesis of Pharmaceuticals -- An Integrated Approach to Developing Chemoenzymatic Processes at the Industrial Scale -- Scale-Up in Microwave-Accelerated Organic Synthesis -- Solid Supported Reagents in Multi-Step Flow Synthesis -- Solid-Phase Supported Synthesis: A Possibility for Rapid Scale-Up of Chemical Reactions -- Microstructured Reactors for Development and Production in Pharmaceutical and Fine Chemistry. , English

Additional Edition: ISBN 3-642-42084-2

Additional Edition: ISBN 3-540-70848-0

Language: English

DOI: 10.1007/978-3-540-70849-0

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Format: 1 online resource (xii, 308 pages) : , illustrations

ISBN: 0471460729 , 9780471460725 , 0471378283 , 9780471378280 , 0471220442 , 9780471220442

Content: Solid-phase synthesis of carbohydrates presents unique challenges to synthetic chemists and currently represents one of the hottest areas of research in bioorganic chemistry. Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries addresses the exciting expectation that solid-phase assembly of oligosaccharides will have a fundamental impact on the field of glycobiology. This publication details the methodologies currently investigated for the attachment of carbohydrates to beads, synthesis including coupling strategies, and removal of the product from beads.

Note: Solid-phase carbohydrate synthesis : the early work / Wilm-Christian Haase and Peter H. Seeberger -- The glycal assembly method on solid supports : synthesis of oligosaccharides and glycoconjugates / Pier F. Cirillo and Samuel J. Danishefsky -- The sulfoxide glycosylation method and its application to solid-phase oligosaccharide synthesis and the generation of combinatorial libraries / Carol M. Taylor -- The use of O-glycosyl trichloroacetimidates for the polymer-supported synthesis of oligosaccharides / Laurent Knerr and Richard R. Schmidt -- Synthesis of oligosaccharides on solid support using thioglycosides and pentenyl glycosides / Valentin Wittmann -- Solid-phase oligosaccharide synthesis using glycosyl phosphates / Wilm-Christian Haase, Obadiah J. Plante, and Peter H. Seeberger -- Stereoselective [beta]-mannosylation on polymer support / Yukishige Ito and Hiromune Ando -- Tools for "on-bead" monitoring and analysis in solid-phase oligosaccharide synthesis / Wilm-Christian Haase, Peter H. Seeberger, and Susan S. Pochapsky -- Polyethyleneglycol [omega]-monomethylether (MPEG)-supported solution-phase synthesis of oligosaccharides / Jiri J. Krepinsky and Stephen P. Douglas -- Two-direction glycosylations for the preparation of libraries of oligosaccharides / Geert-Jan Boons and Tong Zhu -- Carbohydrate libraries in solution using thioglycosides : from multistep synthesis to programmable, one-pot synthesis / Eric E. Simanek and Chi-Huey Wong -- Carbohydrate libraries by the random glycosylation approach / Osamu Kanie and Ole Hindsgaul -- Solid-phase synthesis of biologically important glycopeptides / Nicole Bézay and Horst Kunz -- Preparation and screening of glycopeptide libraries / Phaedria M. St. Hilaire, Koen M. Halkes, and Morten Meldal.

Additional Edition: Print version: Solid support oligosaccharide synthesis and combinatorial carbohydrate libraries. New York : Wiley, ©2001 ISBN 0471378283

Language: English

Keywords: Electronic books. ; Electronic books.

DOI: 10.1002/0471220442

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/0471220442

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/0471220442

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Format: 1 online resource (XVI, 432 p.)

Edition: 2. rev. and exten. edition

ISBN: 9783110693676

Series Statement: De Gruyter Textbook ; Volume 1

Content: The fully up-dated edition of the two-volume work covers both the theoretical foundation as well as the practical aspects. Presenting the complete insight into driving a chemical reaction provides a deep understanding for new potential technologies. Updated overview on devices and new key concepts of experimental procedures. Vol. 2: Applications.

Note: Frontmatter -- , Preface -- , Acknowledgments -- , Contents -- , About the editors -- , Contributing authors -- , 1 Fundamentals of flow chemistry -- , 2 Principles of controlling reactions in flow microreactor chemistry -- , 3 Technology overview/overview of the devices -- , 4 Practical aspects of performing continuous flow chemistry -- , 5 When and how to start flow chemistry -- , 6 Fundamentals of continuous manufacturing PAT: sampling, analysis, and automation -- , 7 Continuous gas–liquid and liquid–liquid separation -- , 8 Mitigation of chemical hazards under continuous flow conditions -- , 9 Diazo(diphenyl)methane synthesis in continuous flow: an experiment for the undergraduate teaching laboratory -- , 10 Continuous flow catalysis -- , 11 Gaseous reagents in flow chemistry -- , Answers to the study questions -- , Index , In English.

Additional Edition: ISBN 9783110693775

Additional Edition: ISBN 9783110693591

Language: English

DOI: 10.1515/9783110693676

URL: https://doi.org/10.1515/9783110693676

URL: https://www.degruyter.com/isbn/9783110693676

URL: https://doi.org/10.1515/9783110693676

URL: https://www.degruyter.com/isbn/9783110693676

UID:

Format: 1 online resource (xii, 308 pages) : , illustrations

ISBN: 0471460729 , 9780471460725 , 0471378283 , 9780471378280 , 0471220442 , 9780471220442

Content: Solid-phase synthesis of carbohydrates presents unique challenges to synthetic chemists and currently represents one of the hottest areas of research in bioorganic chemistry. Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries addresses the exciting expectation that solid-phase assembly of oligosaccharides will have a fundamental impact on the field of glycobiology. This publication details the methodologies currently investigated for the attachment of carbohydrates to beads, synthesis including coupling strategies, and removal of the product from beads.

Note: Solid-phase carbohydrate synthesis : the early work / Wilm-Christian Haase and Peter H. Seeberger -- The glycal assembly method on solid supports : synthesis of oligosaccharides and glycoconjugates / Pier F. Cirillo and Samuel J. Danishefsky -- The sulfoxide glycosylation method and its application to solid-phase oligosaccharide synthesis and the generation of combinatorial libraries / Carol M. Taylor -- The use of O-glycosyl trichloroacetimidates for the polymer-supported synthesis of oligosaccharides / Laurent Knerr and Richard R. Schmidt -- Synthesis of oligosaccharides on solid support using thioglycosides and pentenyl glycosides / Valentin Wittmann -- Solid-phase oligosaccharide synthesis using glycosyl phosphates / Wilm-Christian Haase, Obadiah J. Plante, and Peter H. Seeberger -- Stereoselective [beta]-mannosylation on polymer support / Yukishige Ito and Hiromune Ando -- Tools for "on-bead" monitoring and analysis in solid-phase oligosaccharide synthesis / Wilm-Christian Haase, Peter H. Seeberger, and Susan S. Pochapsky -- Polyethyleneglycol [omega]-monomethylether (MPEG)-supported solution-phase synthesis of oligosaccharides / Jiri J. Krepinsky and Stephen P. Douglas -- Two-direction glycosylations for the preparation of libraries of oligosaccharides / Geert-Jan Boons and Tong Zhu -- Carbohydrate libraries in solution using thioglycosides : from multistep synthesis to programmable, one-pot synthesis / Eric E. Simanek and Chi-Huey Wong -- Carbohydrate libraries by the random glycosylation approach / Osamu Kanie and Ole Hindsgaul -- Solid-phase synthesis of biologically important glycopeptides / Nicole Bézay and Horst Kunz -- Preparation and screening of glycopeptide libraries / Phaedria M. St. Hilaire, Koen M. Halkes, and Morten Meldal.

Additional Edition: Print version: Solid support oligosaccharide synthesis and combinatorial carbohydrate libraries. New York : Wiley, ©2001 ISBN 0471378283

Language: English

Keywords: Electronic books.

DOI: 10.1002/0471220442

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/0471220442

UID:

Format: 1 Online-Ressource (Approx. 1200 p. 540 illus., 240 illus. in color).

ISBN: 978-4-431-54836-2

Language: English

DOI: 10.1007/978-4-431-54836-2

URL: Volltext  (URL des Erstveröffentlichers)

UID:

Format: 1 Online-Ressource (Approx. 1200 p. 540 illus., 240 illus. in color).

ISBN: 978-4-431-54836-2

Language: English

DOI: 10.1007/978-4-431-54836-2

URL: Volltext  (URL des Erstveröffentlichers)