ISSN:
1548-7091
,
1548-7091
Content:
The flagellate Euglena gracilis contains a photoactivated adenylyl cyclase (PAC), consisting of the flavoproteins PACa and PACb. Here we report functional expression of PACs in Xenopus laevis oocytes, HEK293 cells and in Drosophila melanogaster, where neuronal expression yields light-induced changes in behavior. The activity of PACs is strongly and reversibly enhanced by blue light, providing a powerful tool for light-induced manipulation of cAMP in animal cells.
Content:
Peer Reviewed
In:
Nature Methods, , 2007, 4,2006,1, Seiten 39-42, 1548-7091
Language:
English
URN:
urn:nbn:de:kobv:11-10085394
URL:
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