UID:
almafu_9959234715502883
Format:
1 online resource (600 p.)
ISBN:
1-281-91190-9
,
9786611911904
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981-277-205-7
Content:
The role played by structural proteomics in the first decade of the 21st century is equivalent to that played by the Human Genome Project in the last decade of the 20th century. The development of high-throughput technologies that permit the solution of hundreds of 3D structures of individual proteins, protein-protein complexes and protein-drug complexes, just by one laboratory in a single year, will provide a knowledge base which will change the face of structural biology. This will have an immediate influence on medicinal chemistry and molecular pharmacology, as well as an increasing impact
Note:
Description based upon print version of record.
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ch. 1. The importance of target selection strategies in structural biology / Enrique E. Abola and Raymond C. Stevens -- ch. 2. The impact of structural proteomics on macromolecular structure databases / James D. Watson and Janet M. Thornton -- ch. 3. The impact of 3D structures on a protein knowledgebase: from proteins to systems / Ursula Hinz and Amos Bairoch -- ch. 4. Bioinformatics of protein function / Arthur M. Lesk ... [et al.] -- ch. 5. Comparative modeling in structural genomics / John Moult -- ch. 6. The contribution of structural proteomics to understanding the function of hypothetical proteins / Michael D. Suits ... [et al.] -- ch. 7. Intrinsically disordered proteins / Peter Tompa -- ch. 8. Metalloproteins: structure, conservation and prediction of metal binding sites / Marvin Edelman ... [et al.] -- ch. 9. The impact of protein expression methodologies on structural proteomics / A. Chesneau, H. Yumerefendi and D. J. Hart -- ch. 10. Protein complexes assembly by multi-expression in bacterial and eukaryotic hosts / Christophe Romier -- ch. 11. The impact of structural proteomics on the prediction of protein-protein interactions / Christina Kiel and Luis Serrano -- ch. 12. Cryo-electron microscopy in the era of structural proteomics / Alasdair C. Steven and David M. Belnap -- ch. 13. On NMR-based structural proteomics / Thomas Szyperski -- ch. 14. Structural proteomics in relation to signaling pathways / Florence Bedez, Arnaud Poterszman and Dino Moras -- ch. 15. The impact of structural proteomics on drug design / Yuan-Ping Pang -- ch. 16. Structural proteomics of emerging viruses: the examples of SARS-CoV and other coronaviruses / Rolf Hilgenfeld ... [et al.] -- ch. 17. High-throughput technologies for structural biology: the protein structure initiative perspective / Andrzej Joachimiak -- ch. 18. European structural proteomics - a perspective / Susan Daenke, E. Yvonne Jones and David I. Stuart -- ch. 19. Structural genomics and structural proteomics: a global perspective / Lucia Banci ... [et al.] -- ch. 20. Policies in structural genomics/structural proteomics. A. The protein structure initiative: policies and update / John Norvell and Jeremy Berg. B. Structural genomics in European framework programs / Josefina Enfedaque, Sa�sa Jenko Kokalj and Jacques Remacle. C. Policy aspects in structural genomics/proteomics / Barbara Skene. D. Policies and updates of the RIKEN structural genomics/proteomics initiative / Shigeyuki Yokoyama. E. The international structural genomics organization: policies for structural genomics / Thomas C Terwilliger ... [et al.].
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English
Additional Edition:
ISBN 981-277-204-9
Language:
English
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