UID:
edoccha_9961326407402883
Format:
1 online resource (266 pages)
Edition:
First edition.
ISBN:
0-443-15961-0
Content:
Drug-delivery Systems of Phytochemicals as Therapeutic Strategies in Cancer Therapy elucidates the importance of various phytochemicals in cancer therapy and explains various routes/methods to deliver phytochemicals for overcoming the problems associated with delivery systems in cancer treatment. Several nanotechnological methods are presented to enhance drug solubility, sustainability, bioavailability, and gastrointestinal permeability of these phytochemicals. Current understanding of the relevant information presented on therapeutic strategies in cancer therapy fulfils the requirements of oncologists, molecular biologists, pharmacologist and related researchers who want to work in the areas of drug development targeting phytochemicals for cancer therapy.
Note:
Front Cover -- DRUG-DELIVERY SYSTEMS OF PHYTOCHEMICALS AS THERAPEUTIC STRATEGIES IN CANCER THERAPY -- DRUG-DELIVERY SYSTEMS OF PHYTOCHEMICALS AS THERAPEUTIC STRATEGIES IN CANCER THERAPY -- Copyright -- Dedication -- Contents -- About the authors -- Preface -- Introduction -- 1 - Significance of phytochemicals in cancer therapy -- Introduction -- Current challenges in cancer treatment and management -- Phytodrugs: A historical view -- Natural products -- Nutraceuticals -- Anticancer phytocomponents -- Molecular targets of phytochemicals -- Plants compounds targeting ROS and autophagy for cancer treatment -- Clinical trial of phytochemicals for cancer therapy -- Conclusion and future prospectives -- References -- 2 - Emerging need of delivery systems for plant metabolites -- Introduction -- Novel drug delivery methods -- Patterns of drug delivery -- Drug modifications -- Microenvironmental modifications -- Drug delivery systems -- Novel drug delivery systems for plants metabolites -- Benefits of drug delivery system (Pagar & -- Khandbahale, 2019) -- Conclusion and future prospectives -- References -- 3 - Phytosome: A promising drug delivery system for cancer therapy -- Introduction -- Principle for synthesis of phytosomes -- Composition of phytosomes -- Phospholipids -- Solvent for phytosome -- Stoichiometric ratio of phytoactive components and phospholipid -- Anticancer activity of phytosomes-formulated phytochemicals -- Challenges of phytosomal products to commercialization -- Conclusion and future prospect -- References -- 4 - Exosome-based delivery systems for natural compounds in cancer therapy -- Introduction -- Biogenesis of exosomes -- Role of exosomes in cancer -- Modification of exosome-based drug delivery system -- Encapsulation method of therapeutic regimens into exosome -- Surface modification of exosomes with therapeutic compounds.
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Modifications of exosome for target site -- Application of exosomes in delivery of phytochemicals for cancer treatment -- Paclitaxel -- Celastrol -- β-Elemene -- Curcumin-primed and curcumin-loaded exosomes -- Current limitations and challenges -- Conclusions -- References -- 5 - Potential implications of ethosomes and transethosomes to deliver phytomedicine in cancer treatment -- Introduction -- Ethosomes -- Transethosomes -- Application of ethosomes and transethosomes in phytodrug delivery -- Advantages and disadvantages of ethosomes and transethosomes -- Conclusion and future perspectives -- References -- 6 - Chitosan-based drug delivery of plant metabolites for the treatment of breast cancer -- Introduction -- Chitosan -- Source of chitosan -- Chemical structure -- Chitosan-based delivery system in oncotherapy -- Chemotherapeutic drugs delivery -- Chitosan-based systems as genes carriers -- Chitosan-based nanosystems for conventional agents -- Breast cancer drug delivery by chitosan-based system -- Self-assembled amphiphilic chitosan nanoparticles for quercetin delivery -- Biodegradable nanocarriers based on chitosan-modified mesoporous silica nanoparticles for delivery of methotrexate -- Drug administration by drug-loaded chitosan-coated magnetic nanoparticles -- Conclusions -- References -- 7 - Sporopollenin-based targeted drug delivery system for gastrointestinal cancer -- Introduction -- Chemical structure of sporopollenin -- Sporopollenin-indomitable biopolymer for biomedical implications -- Sporopollenin-based drug delivery systems -- Sporopollenin microcages for delivery of oxaliplatin -- Carboxymethylpachymaran/metal ion on sunflower sporopollenin as delivery vehicles -- Delivery of ibuprofen by sporopollenin -- Impact of sporopollenin encapsulation on stability to digestion and gut microbes -- Conclusions -- References.
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8 - Nanotechnology-based delivery system for phytochemicals in cancer therapy -- Introduction -- Branches of nanotechnology -- Nanoengineering -- Green nanotechnology -- Wet nanotechnology -- Research breakthrough in nanotechnology for development of anticancer drugs -- Advancement in nanotechnology targeting cancer -- Nanodrug delivery systems of phytochemicals for cancer therapy -- Nanoformulation of phytochemicals for cancer treatments -- Nanocarrier-based codelivery of phytochemicals with conventional drugs for cancer treatment -- Clinical applications -- Conclusions and future perspective -- References -- 9 - Delivery system of phenolic compounds for the treatment of lung cancer -- Introduction -- Biological function of polyphenols in cancer -- Classifications of polyphenols -- Biological functions of polyphenols in cancer -- Bioavailability of phenolic compounds -- Polyphenolics drug delivery systems -- Rutin-loaded drug delivery systems -- Baicalin-loaded drug delivery systems -- Chrysin-loaded drug delivery systems -- Apigenin-loaded drug delivery systems -- Ginkgo biloba extract-loaded drug delivery systems -- Naringenin-loaded drug delivery systems -- Drug delivery -- Nanoparticulate delivery systems -- Pulmonary delivery -- Methyl gallate@ZIF-L hybrid as drug delivery system for lung cancer treatment -- Curcumin-loaded solid lipid nanoparticles (Cur-SLNs) as drug delivery system for the lung cancer therapy -- Conclusion and future perspective -- References -- 10 - Advancement in drug delivery systems of curcumin for cancer chemoprevention -- Introduction -- Drug delivery vehicle for curcumin -- Biodegradable curcumin-loaded magnetic microsphere -- Curcumin loaded mesoporous silica -- Curcumin-loaded carboxymethylpachymaran-coated zein -- Engineered UIO-66 metal-organic complex for delivery of curcumin.
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Microsponges as gastroretentive drug delivery system of curcumin -- Folate attached: curcumin-loaded Fe3O4 nanoparticles -- Curcumin-loaded SNEDDS -- Glycyrrhizic acid micellar hydrogel carriers for delivery of curcumin -- Drug delivery systems for synergistic application of curcumin with anticancer regimens -- Curcumin-piperine-loaded human serum albumin nanoparticles against carcinoma cells -- Drug delivery of curcumin and platinum drugs in polymeric micelles -- Codelivery of etoposide and curcumin for treatment of gastric cancer -- Curcumin-bortezomib-loaded polymeric nanoparticles for carcinoma therapy -- Dual drug delivery system for coadministration of curcumin and 5-fluorouracil -- Codelivery of doxorubicin and curcumin through polypeptide nanocarrier -- Conclusions and future prospective -- References -- 11 - Drug delivery system for saponins in cancer treatments -- Introduction -- Classification of saponins -- Sources of saponins -- Natural sources -- Synthetic sources -- Anticancer event of saponin -- Chemoprevention -- Antiinflammatory -- Cell cycle arrest -- Cytotoxicity impact of saponins -- Apoptosis -- Autophagy -- Metastasis -- Saponin in multidrug-resistant carcinoma -- Drug delivery system for saponins -- Saponin emulsion as drug delivery system -- Saponins as surfactant -- Release of nanofiber membrane loaded with saponin -- Saponin-loaded chitosan nanoparticles -- Saponin-loaded montmorillonite-human serum albumin nanocomposites in cancer therapy -- A novel saponin liposome based on the couplet medicines -- Conclusions and future perspectives -- References -- 12 - Administration of plant-derived terpenoids in cancer management -- Introduction -- Mechanism of action of terpenoids against cancer development -- Monoterpenoids -- Thymol -- Menthol -- Auraptene -- Sesquiterpenoids and sesquiterpene lactones -- Sesquiterpene lactones.
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Dehydrocostus lactone -- Helenalin -- Diterpenoids -- Triptolide -- Crocetin -- Phytol -- Triterpenoids -- Ursolic acid -- Betulinic acid -- Lupeol -- Terpene-based therapeutic deep eutectic systems against colorectal cancer -- Coencapsulation and sustained release of terpenes from injectable PELGE nanoparticles -- The combination of nanomicelles with terpenoids for skin drug delivery -- Development of enhanced drug delivery vehicles for three cannabis-based terpenes -- Patents of some terpenoids as an anticancer compound -- Conclusions and future perspectives -- References -- 13 - Therapeutic role of essential oils in malignancies through drug delivery mechanisms -- Introduction -- Activity of essential oils/their constituents on cancer cell lines -- Anticancer properties of essential oils -- Major issues in clinical use of essential oils -- Effective essential oil delivery in living systems -- Aromatherapy: the roots of a bio-based solution -- Drug delivery strategies impact essential oil activity -- Applications of essential oils in combination with synthetic drug -- Problems of current technology -- Nanoencapsulation approach -- Targeted nanodelivery systems for cancer treatment -- Nanodelivery systems of essential oils for breast cancer -- Nanodelivery systems for lung cancer -- Nanodelivery systems for liver cancer -- Conclusion and future perspectives -- References -- 14 - Development of codelivery systems for phytochemicals and targeted siRNA in treatment of cancer -- Introduction -- Event of siRNA action -- Implication of siRNA in cancer therapy -- Phytochemicals-siRNA codelivery -- Docetaxel-siRNA codelivery -- Paclitaxel-siRNA codelivery -- Etoposide-siRNA codelivery -- Conclusions -- References -- 15 - Future challenges of drug-delivery systems for phytochemicals in cancer management -- Introduction.
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Challenges of phytochemicals in cancer treatment.
Additional Edition:
ISBN 9780443159602
Language:
English
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