UID:
almafu_9961427237202883
Format:
1 online resource (1 video file (36 min.)) :
,
sound, color
Note:
Retrieved April 16, 2024, from https://hstalks.com/bs/79/.
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Introduction -- Sir Archibald Garrod -- JBS Haldane -- Examples of diseases -- Metabolism of Dietary Folate -- Conceptual and analytic challenges -- Outline - Designs -- Study designs -- Outline - simple pairwise analyses -- Definition - NOTA BENE -- Example: risk of disease and lof odds of disease -- Different scale gives different in interaction (1) -- Different scale gives different in interaction (2) -- The standard "test for interaction" -- Example: all relationships should be known -- Screening for stratum-specific effects -- Gene associated with risk in any subgroup -- Exposure associated with risk in any genotype -- Example: DNA repair gene XRCC1 -- Example: test for genetic effect -- Beyond binary G and E -- Outline - power considerations -- Power -- Programs for power calculations -- Parameters to specify -- Ge_trend example -- Ge_trend example: results -- Ge_trend example: results under minimum power -- Ge_trend example: results under maximum power -- Sample size is necessary to detect genetic effect -- Test for "interaction" -- Screening for genetic effect -- Outline - more sophisticated analyses -- Beyond one gene-one environmental factor -- Ordinal coding -- Ordinal coding - multiple loci -- Ordinal coding - three parameter model -- Hierarchical Models -- Example [Aragaki et al. 1997] -- Machine learning methods -- Relation between training- and test-set error -- Caveat Emptor -- Final Thoughts -- Software -- References (1) -- References (2).
Language:
English
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