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  • 1
    Book
    Book
    Basel [u.a.] : Karger
    UID:
    gbv_279351798
    Format: S. 289 - 416 , Ill., graph. Darst
    ISBN: 3805565003
    Series Statement: Intervirology 39,5/6
    Note: Literaturangaben
    Language: English
    Keywords: Cytomegalie-Virus ; Aufsatzsammlung
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Online Resource
    Online Resource
    Berlin, Heidelberg :Springer Berlin Heidelberg :
    UID:
    almahu_9949419297702882
    Format: XIII, 479 p. , online resource.
    Edition: 1st ed. 2008.
    ISBN: 9783540773498
    Series Statement: Current Topics in Microbiology and Immunology, 325
    Content: The earliest observation of cytomegalovirus (CMV) interactions with the host cell was owl eye cytopathology in various tissues. It was recognized in the early 1970s that human CMV caused in utero infections resulting in congenital brain damage and other sensory neurological complications. Events of the 1980s and early 1990s, such as the wide application of solid organ and bone marrow transplantation and the emergence of AIDS, put the spotlight on human CMV. We understood that the virus was an opportunistic agent associated with immunosuppression. The golden age of cytomegalovirus research was ushered in during the late 1970s and early 1980s by a set of powerful new technologies that included restriction enzymes, DNA cloning, DNA sequencing, and open reading frame prediction. The genetic manipulation and propagation of novel CMV strains was accelerated with the app- cation of bacterial artificial chromosome technology. Today, we still struggle to understand the full spectrum of disease associated with human CMV. To the molecular biologist, CMV is a master of regulation in the eukaryotic cell where it either replicates or remains latent. To the immunologist, CMV is a master of immune evasion with tools to escape both the innate and acquired immune responses. The use of animal models with non-human CMVs has become significantly more sophisticated and tied to a more certain understanding of the interrelationships of non-human and human CMV genes.
    Note: Human Cytomegalovirus Genome -- Human Cytomegalovirus microRNAs -- Mutagenesis of the Cytomegalovirus Genome -- Cytomegalovirus Cell Tropism -- Virus Entry and Innate Immune Activation -- Functions of Human Cytomegalovirus Tegument Proteins Prior to Immediate Early Gene Expression -- Initiation of Cytomegalovirus Infection at ND10 -- Functional Roles of the Human Cytomegalovirus Essential IE86 Protein -- Nuts and Bolts of Human Cytomegalovirus Lytic DNA Replication -- Interactions of Human Cytomegalovirus Proteins with the Nuclear Transport Machinery -- Structure and Formation of the Cytomegalovirus Virion -- Human Cytomegalovirus Modulation of Signal Transduction -- Chemokines and Chemokine Receptors Encoded by Cytomegaloviruses -- Subversion of Cell Cycle Regulatory Pathways -- Modulation of Host Cell Stress Responses by Human Cytomegalovirus -- Control of Apoptosis by Human Cytomegalovirus -- Aspects of Human Cytomegalovirus Latency and Reactivation -- Murine Model of Cytomegalovirus Latency and Reactivation -- Cytomegalovirus Immune Evasion -- Cytomegalovirus Vaccine Development -- Cytomegalovirus Infection in the Human Placenta: Maternal Immunity and Developmentally Regulated Receptors on Trophoblasts Converge -- Mechanisms of Cytomegalovirus-Accelerated Vascular Disease: Induction of Paracrine Factors That Promote Angiogenesis and Wound Healing -- Manifestations of Human Cytomegalovirus Infection: Proposed Mechanisms of Acute and Chronic Disease.
    In: Springer Nature eBook
    Additional Edition: Printed edition: ISBN 9783540848769
    Additional Edition: Printed edition: ISBN 9783540773481
    Additional Edition: Printed edition: ISBN 9783642445132
    Language: English
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  • 3
    Online Resource
    Online Resource
    Berlin : Springer
    UID:
    gbv_1647128641
    Format: Online-Ressource (digital)
    ISBN: 9783540773498
    Series Statement: Current Topics in Microbiology and Immunology 325
    Content: This volume has gathered some of the experts in the field to review aspects of our understanding of CMV and to offer perspectives of the current problems associated with CMV. The editors and authors hope that the chapters will lead to a better understanding of the virus that will assist in the development of new and unique antivirals, a protective vaccine, and a full understanding of CMV's involvement in human disease.
    Content: This volume has gathered some of the experts in the field to review aspects of our understanding of CMV and to offer perspectives of the current problems associated with CMV. The editors and authors hope that the chapters will lead to a better understanding of the virus that will assist in the development of new and unique antivirals, a protective vaccine, and a full understanding of CMV's involvement in human disease
    Note: Description based upon print version of record , CONTENTS; Human Cytomegalovirus Genome; Human Cytomegalovirus microRNAs; Mutagenesis of the Cytomegalovirus Genome; Cytomegalovirus Cell Tropism; Virus Entry and Innate Immune Activation; Functions of Human Cytomegalovirus Tegument ProteinsPrior to Immediate Early Gene Expression; Initiation of Cytomegalovirus Infection at ND10; Functional Roles of the Human Cytomegalovirus EssentialIE86 Protein; Nuts and Bolts of Human Cytomegalovirus Lytic DNA Replication; Interactions of Human Cytomegalovirus Proteins withthe Nuclear Transport Machinery , Structure and Formation of the Cytomegalovirus VirionHuman Cytomegalovirus Modulation of Signal Transduction; Chemokines and Chemokine Receptors Encodedby Cytomegaloviruses; Subversion of Cell Cycle Regulatory Pathways; Modulation of Host Cell Stress Responsesby Human Cytomegalovirus; Control of Apoptosis by Human Cytomegalovirus; Aspects of Human Cytomegalovirus Latency and Reactivation; Murine Model of Cytomegalovirus Latency and Reactivation; Cytomegalovirus Immune Evasion; Cytomegalovirus Vaccine Development , Cytomegalovirus Infection in the Human Placenta: MaternalImmunity and Developmentally Regulated Receptorson Trophoblasts ConvergeMechanisms of Cytomegalovirus-Accelerated Vascular Disease:Induction of Paracrine Factors That Promote Angiogenesisand Wound Healing; Manifestations of Human Cytomegalovirus Infection:Proposed Mechanisms of Acute and Chronic Disease
    Additional Edition: ISBN 9783540773481
    Additional Edition: Buchausg. u.d.T. Human cytomegalovirus Berlin : Springer, 2008 ISBN 3540773487
    Additional Edition: ISBN 9783540773481
    Language: English
    Subjects: Medicine
    RVK:
    Keywords: Cytomegalie-Virus ; Cytomegalie-Virus ; Infektion ; Aufsatzsammlung
    URL: Cover
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  • 4
    UID:
    gbv_766166163
    ISBN: 9781908230195
    In: Cytomegaloviruses ; Vol. 1, [Wymondham,] Norfolk : Caister Acad. Press, 2013, (2013), Seite 152-173, 9781908230195
    In: year:2013
    In: pages:152-173
    Language: English
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