Format:
Online-Ressource (XIII, 317 p. 49 illus., 21 illus. in color, online resource)
ISBN:
9781461482291
Series Statement:
AAPS Advances in the Pharmaceutical Sciences Series 7
Content:
Written by leading researchers in the transporter field from academia, pharmaceutical industry and medicines agencies, this book encompasses examples and advises on how membrane transporters can be dealt with in academic-industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. Methods and examples of in vitro characterization of single transporters in intestine, liver and kidney are described as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are discussed as well as the perspectives of applying targeted proteomics and mechanistic modeling in this process. Yuichi Sugiyama is Head of Sugiyama Laboratory, RIKEN Innovation Center, RIKEN Research Cluster for Innovation, Yokohama, Japan, and previously Professor, Department of Molecular Pharmacokinetics at the University of Tokyo from 1991 through to his retirement from the University in 2012. He is coauthor of more than 580 publications in international journals, as well as 270 book chapters and review articles. His work is internationally recognized by prestigious awards, including AAPS Distinguished Pharmaceutical Scientist Award (2003), FIP Hoest Madsen Gold Medal (2009), “Medal with Purple Ribbon” given by Government in 2010 and B. Brodie Award from ASPET (2012). Professor Sugiyama has been ranked as the top (#1) cited scientist in the fi eld of Pharmacology & Toxicology (1997-2007). He served as the chairman of Board of Pharmaceutical Sciences in FIP, and was also the president of both International Society for the Study of Xenobiotics (ISSX) and Japanese Society for Xenobiotic Metabolism and Disposition (JSSX). Bente Steff ansen is Associate Professor in Transporters in ADME at Th e Faculty of Health and Medical Sciences, University of Copenhagen. She graduated with MSc (pharm) in 1989 from the Royal Danish School of Pharmacy and obtained her PhD in 1994 under the Danish Research Academy within the fi eld of prodrug design aimed for improved drug delivery. Dr Steff ansen has published more than 60 research articles, edited a book, and serves as the program director for pharmaceutical education at the University of Copenhagen. She is a member of the Che ...
Note:
Description based upon print version of record
,
Membrane Transporters in ADMEIn Vitro Characterization of Transporter Mediated Permeability -- In Vitro Characterization of Interactions with Drug Transporting Proteins -- In Vivo Characterization of Interactions on Transporters -- Application of Targeted Proteomics in ADME for IVIVE -- Prediction of Transporter Mediated Drug-Drug Interaction from In Vitro Data -- Accounting for Transporters in Renal Clearance: Towards a Mechanistic Kidney Model (Mech KiM) -- Analysis of Intestinal Transporters -- Analysis of Hepatic Transport Proteins -- Analysis of Renal Transporters -- The Role of Transporters During Drug Development: Regulatory Science Perspective from the FDA -- Industrial Evaluation of Drug Transporters in ADME.
Additional Edition:
ISBN 9781461482284
Additional Edition:
Druckausg. ISBN 978-146-148-228-4
Language:
English
DOI:
10.1007/978-1-4614-8229-1
URL:
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