UID:
almafu_9961427333802883
Format:
1 online resource (1 streaming video file (29 min.)) :
,
color, sound
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002859
Content:
Of the genetic, pathophysiology and clinical features of Huntington's disease -- Potential drug targets in development for Huntington's disease -- The importance of biomarkers in Huntington's disease -- Current biomarkers in development in Huntington's disease.
Note:
Retrieved April 15, 2024, from https://hstalks.com/bs/2510/.
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Introduction -- George Huntington -- HD characteristics -- The HD mutation and huntingtin protein -- Htt protein -- Cellular pathogenic pathways of Htt -- HD is not just a disease of the basal ganglia -- HD is more than a disease of the brain -- Overview of our HD research at UCL -- Delaying disease onset -- Virtual explosion of HD recent research -- What treatments are on the way -- Novel therapies in or near trials -- Promising preclinical targets in the pipeline -- Understanding the disease in humans -- HD clinical trials: challenges -- Exploring for biomarkers at TRACKHD center -- TRACKHD study design (1) -- TRACKHD study design (2) -- Published results in The Lancet Neurology -- Baseline paper - 2009 -- Baseline imaging results -- Baseline cognitive results -- Baseline qMotor and oculomotor results -- 12-months longitudinal analysis - January 2011 -- TRACK-HD premanifest A subject -- 12-month imaging change -- 12-month cognitive change (1) -- 12-month cognitive change (2) -- 12-month qMotor change -- Analysis of 24 month observational data -- 24-month change in whole brain atrophy -- 24-month change in caudate volume -- 24-month change in grey matter -- 24-month change in white matter -- Consistent change in early stage HD -- Potential outcome measures for clinical trials -- TRACK-HD 24-month effect sizes -- Track-HD battery sample size estimates -- Atrophy (1) -- Atrophy (2) -- Mutant HTT measured patients' WBCs -- Mutant huntington fragmentation in immune cells -- Mutant HTT in monocytes (1) -- Mutant HTT in monocytes (2) -- Study results - summary -- When does neurodegeneration begin? -- Timescale for brain changes -- Challenges remaining -- Hypotheses to test -- Increased neural activity in premanifest HD -- TrackOnHD - aims -- The premanifest phase of neurodegeneration -- Acknowledgements -- The UCL ION HD team -- Credits.
Language:
English
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