UID:
almafu_9961427218102883
Format:
1 streaming video file (59 min.) :
,
color, sound
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005854
Note:
Retrieved April 5, 2024, from https://hstalks.com/bs/177/.
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Introduction -- Topics -- Overview of mitochondrial disorders -- Electron transport chain -- Mitochondrial disorders -- Morbidity map -- Classic phenotypes in adults -- What genes cause OXPHOS disorders? -- Mitochondrial diagnosis -- Clinical features -- Clinical features in children -- My general approach -- My general approach (2) -- Biomarkers (blood, urine, CSF) -- My general approach (3) -- EM/LM changes -- Mitochondrial diagnosis - genetic -- Mitochondrial dysfunction -- Mitochondrial dysfunction (2) -- Treatment strategies - exercise -- Pathological disorders vs physiological adaptations -- Contractile activity determines phenotype (1) -- Gene shifting - satellite cell biology -- mtDNA gene shifting -- Resistance training in mitochondrial myopathy -- Muscle damage and regeneration in MM group -- Contractile activity determines phenotype (2) -- Endurance exercise in mitochondrial disease -- Endurance exercise training (1) -- Endurance exercise training (2) -- D257A knock-in - mutator mice -- Putting an END to aging -- Exercise attenuates many aging features. -- Endurance - brain atrophy & cardiac hypertrophy -- Endurance - skin histological alterations -- Encouraging exercise in children -- Treatment strategies - nutrition -- Nutritional inadequacy in patients with MD -- MD vs. mitochondrial disease -- Serum vitamin levels (1) -- Serum vitamin levels (2) -- Habitual diet (1) -- Habitual diet (2) -- What about a ketogenic diet for seizures? -- Habitual diet - high fat/ketogenic? -- What about other deficiencies? -- Clinical trials in mitochondrial disease -- Low muscle TCr/PCr stores -- Creatine in the body -- Potential benefit in mitochondrial disorders -- Benefit in mitochondrial disorders -- Mitochondrial disorders - CoQ10 treatment -- RCT of CoQ10 in mitochondrial disorders -- Idebenone and LHON -- Mito-cocktail approach (1) -- Mito-cocktail approach (2) -- Mito-cocktail approach (3) -- Mito-cocktail approach (4) -- Acknowledgements.
Language:
English
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