UID:
almahu_9948026210602882
Format:
1 online resource (713 p.)
ISBN:
1-280-75183-5
,
9786610751839
,
0-08-046966-3
Series Statement:
Handbook of behavioral neuroscience ; v. 16
Content:
Microdialysis is currently one of the most important in vivo sampling methods in physiology and pharmacology. It is used to determine the chemical components of the fluid in the extracellular space of tissues. The technique is now well established in neuroscience research and is used excessively in behavioral neuroscience to determine the concentrations and identities of molecules in brain tissues, and their change due to behavior, hormonal and transmitter changes in the nervous system. The book provides a detailed comprehensive overview of the technology and its applications, including ap
Note:
Includes index.
,
Cover; Handbook of Microdialysis: Methods, Applications and Perspectives; Copyright page; Contents; List of Contributors; Preface; Part One; Section 1: Interpretation and Significance; Chapter 1.1. What did we learn from microdialysis?; I. Introduction; II. Early studies of chemical transmission in the brain in vivo; III. The introduction of microdialysis; IV. Early microdialysis studies in Stockholm; V. Microdialysis and neuropharmacology; VI. Microdialysis problems; VII. Conclusions; References; Chapter 1.2. Microdialysis of glutamate and GABA in the brain: analysis and interpretation
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I. IntroductionII. Analysis of GABA and glutamate; III. Microdialysis of glutamate: interpretation; IV. Microdialysis of GABA: interpretation; V. Conclusions; References; Chapter 1.3. Insights into glutamate physiology: contribution of studies utilizing in vivo microdialysis; I. Glutamate sampling techniques; II. Astrocytes maintain neuronal glutamate; III. Glutamate receptors; IV. Cellular processes capable of glutamate release; V. Synaptic origin of stimulated release; VI. Therapeutic targets detected by microdialysis; VII. Conclusion; References
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Chapter 1.4. The validity of intracerebral microdialysisI. Introduction; II. Theory of single-probe microdialysis; III. Studying basal DA to infer errors in quantitative microdialysis; IV. Data from other neurotransmitters; V. Conclusions; References; Chapter 1.5. Microdialysis in the brain of anesthetized vs. freely moving animals; I. Introduction; II. Advantages and drawbacks of microdialysis in anesthetized and freely moving animals; III. The use of anesthesia in microdialysis; IV. The effects of anesthetics on neurotransmitter systems in the brain
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V. Comparison of neurotransmitter dynamics in the freely moving and anesthetized preparationVI. Conclusions; Acknowledgments; References; Chapter 1.6. Quantitative aspects of brain microdialysis: insights from voltammetric measurements of dopamine next to microdialysis probes; I. Introduction; II. The issue of in vivo calibration; III. An example of in vitro microdialysis where E and R are different; IV. A comment about the concentration-independence of E and R; V. Voltammetry as a tool to investigate in vivo recovery of dopamine
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VI. Comparison of the in vivo extraction and recovery of dopamineVII. A comment regarding in vivo dopamine recovery at zero perfusion velocity; VIII. How important is the difference between E and R?; IX. What do microdialysis results tell us?; X. Concluding remarks; Acknowledgments; References; Section 2: Methods; Chapter 2.1. New methodological aspects of microdialysis; I. Introduction; II. Advancements in microdialysis sampling; III. Conclusions; References; Chapter 2.2. Principles of quantitative microdialysis; I. Introduction; II. Mathematical framework; III. Experimental methodology
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IV. Analysis
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English
Additional Edition:
ISBN 0-444-52276-X
Language:
English
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