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  • 1
    UID:
    almahu_9947389241302882
    Format: X, 166 p. 32 illus., 28 illus. in color. , online resource.
    Edition: 1st ed. 2016.
    ISBN: 9783319277776
    Series Statement: Research and Perspectives in Neurosciences,
    Content: This book has brought together leading investigators who work in the new arena of brain connectomics. This includes ‘macro-connectome’ efforts to comprehensively chart long-distance pathways and functional networks; ‘micro-connectome’ efforts to identify every neuron, axon, dendrite, synapse, and glial process within restricted brain regions; and ‘meso-connectome’ efforts to systematically map both local and long-distance connections using anatomical tracers. This book highlights cutting-edge methods that can accelerate progress in elucidating static ‘hard-wired’ circuits of the brain as well as dynamic interactions that are vital for brain function. The power of connectomic approaches in characterizing abnormal circuits in the many brain disorders that afflict humankind is considered. Experts in computational neuroscience and network theory provide perspectives needed for synthesizing across different scales in space and time. Altogether, this book provides an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.
    Note: Parcellations and connectivity patterns in human and macaque cerebral cortex -- Nanoconnectomics -- Inhibitory cell cypes, circuits and receptive fields in mouse visual cortex -- Form meets function in the brain: observing the activity and structure of specific neural connections -- The network for intracortical communication in mouse visual cortex -- The brain in space -- In-vivo connectivity in monkeys -- Connectome networks: from cells to systems -- Intra- and Inter-hemispheric connectivity supporting hemispheric specialization -- Genetics of the connectome and the ENIGMA project.
    In: Springer eBooks
    Additional Edition: Printed edition: ISBN 9783319277769
    Language: English
    URL: Volltext  (kostenfrei)
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Online Resource
    Online Resource
    Cham :Springer International Publishing AG,
    UID:
    almahu_9949602145502882
    Format: 1 online resource (173 pages)
    Edition: 1st ed.
    ISBN: 9783319277776
    Series Statement: Research and Perspectives in Neurosciences Series
    Note: Intro -- Acknowledgments -- Contents -- List of Contributors -- Nanoconnectomics -- Nanoconnectomics -- Extracellular Space -- Simulating Signaling in Small Spaces -- Precision of Synaptic Plasticity -- References -- Inhibitory Cell Types, Circuits and Receptive Fields in Mouse Visual Cortex -- Differences in Connectivity, Visual Responses and Functional Impact of PV Versus SST Interneurons -- Calretinin (CR) and VIP-Expressing Interneurons Target SST Interneurons -- Functional Impact of VIP Interneurons -- References -- Form Meets Function in the Brain: Observing the Activity and Structure of Specific Neural Connections -- Introduction -- CLARITY -- Clarifying Large Tissue Volumes -- CLARITY-Optimized Light Sheet Microscopy -- Tracking Activity in Deep Genetically Targeted Neurons of Behaving Animals -- Neural Activity that Encodes and Predicts Social Interaction -- Outlook -- References -- The Network for Intracortical Communication in Mouse Visual Cortex -- Introduction -- Thalamocortical Projections to Mouse Visual Cortex -- Cortical Cartography -- Areal Organization of Visual Cortex -- Interareal Connections -- Cortical Hierarchy -- Synaptic Organization of Feedforward and Feedback Connections -- Dorsal and Ventral Processing Streams -- References -- The Brain in Space -- Introduction -- The Promise of Network Theory -- Empirical Evidence for a Principled Model of Cortical Connectivity: The EDR Model -- The Cortical Core-Periphery Structure -- Biology, Clustering and the Importance of Weak Links -- Conclusion and Perspectives -- References -- In-Vivo Connectivity in Monkeys -- Anatomical, Functional and Effective Connectivity in Animal Models -- Towards Causality: Effective Connectivity with Focal Perturbation Tools -- Effective Connectivity: Combined Electrical Microstimulation and Whole-Brain fMRI. , Novel Genetically-Based Perturbation Methods? -- References -- Parcellations and Connectivity Patterns in Human and Macaque Cerebral Cortex -- Introduction -- Cortical Cartography and Parcellation -- Distributed Cortical Connectivity -- Interspecies Registration -- Concluding Comments -- References -- Connectome Networks: From Cells to Systems -- Defining the Connectome -- Brain Networks and Graph Theory -- Topology of Structural Brain Networks -- Microscale -- Mesoscale -- Macroscale -- Comparison Across Scales and Challenges -- Relations Between Structure and Function -- Microscale -- Mesoscale -- Macroscale -- Comparison Across Scales and Challenges -- Future Perspectives -- References -- Intra- and Inter-hemispheric Connectivity Supporting Hemispheric Specialization -- Introduction -- Human Dualism: Two Hands, Two Brains -- Asymmetries Measured with Brain Imaging -- Anatomo-Functional Support of HS -- Gray Matter Macroscopic Asymmetries and HS -- White Matter Connections Supporting HS -- Corpus Callosum -- Intra-hemispheric Structural Connectivity -- Functional Asymmetries and Hemispheric Dominance for Language Assessed with Meta-analysis -- Developmental Course of the Setting Up of Anatomical and Functional Asymmetries -- HS, Cognitive Abilities and Developmental/Psychiatric Diseases -- Cognitive Skills and Asymmetries -- Language HS, Developmental and Psychiatric Diseases -- Inter-individual Variability in HS: Factors at Play -- BILandGIN: A Multimodal Database for Investigating HS -- Conclusion -- References -- Genetics of the Connectome and the ENIGMA Project -- Background to ENIGMA -- Genetic Influences on the Brain -- Finding the Genes Involved -- GWAS of the Brain -- Counterarguments and Power -- Non-biological Information Arising from ENIGMA -- But Do the ENIGMA Genes Affect Disease Risk? -- Searching Brain Images for Statistical Effects. , Brain-Wide Genome-Wide Scanning -- Genetic Screening of the Connectome -- Caveats for Multi-site Genomic Analysis of the Connectome -- Future Directions: Adaptive Connectomics and EPIC -- References -- Index.
    Additional Edition: Print version: Kennedy, Henry Micro-, Meso- and Macro-Connectomics of the Brain Cham : Springer International Publishing AG,c2016 ISBN 9783319277769
    Language: English
    Keywords: Electronic books.
    Library Location Call Number Volume/Issue/Year Availability
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