Kooperativer Bibliotheksverbund

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Format: 1 online resource (76 pages) : , digital, PDF file(s).

Edition: 1st ed.

ISBN: 1-009-38174-1 , 1-009-38175-X

Series Statement: Cambridge elements. Elements in econophysics

Content: Extreme events are ubiquitous in nature and social society, including natural disasters, accident disasters, crises in public health (such as Ebola and the COVID-19 pandemic), and social security incidents (wars, conflicts, and social unrest). These extreme events will heavily impact financial markets and lead to the appearance of extreme fluctuations in financial time series. Such extreme events lack statistics and are thus hard to predict. Recurrence interval analysis provides a feasible solution for risk assessment and forecasting. This Element aims to provide a systemic description of the techniques and research framework of recurrence interval analysis of financial time series. The authors also provide perspectives on future topics in this direction.

Note: Title from publisher's bibliographic system (viewed on 22 Feb 2024). , Introduction -- Recurrence interval distributions -- Memory effects -- Risk estimation and forecasting -- Empirical results and theoretical analyses -- Final remarks.

Additional Edition: ISBN 1-009-48661-6

Language: English

URL: Volltext  (URL des Erstveröffentlichers)

URL: lizenzpflichtig

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Format: 1 online resource (296 pages) : , color illustrations

ISBN: 0-12-802963-3

Note: Includes index. , Front Cover -- DRUG METABOLISM IN DISEASES -- DRUG METABOLISM IN DISEASES -- Copyright -- Contents -- Contributors -- Preface -- 1 - Introduction of Drug Metabolism and Overview of Disease Effect on Drug Metabolism -- INTRODUCTION -- OVERVIEW OF DRUG METABOLISM -- DISEASE EFFECTS ON DRUG METABOLISM -- Liver Disease -- Influence of Infection and Inflammation -- Chronic Kidney Disease -- Disease Effects and Genetic Disorders -- DISEASE EFFECTS ON ABSORPTION PARAMETERS -- Changes in Permeability -- Changes in Gut and Lung Surface Area -- Changes in Gastric Emptying Time -- CHANGES IN BLOOD FLOW TO ORGANS -- CHANGES IN PROTEIN BINDING -- Small Molecules -- Protein Therapeutics -- DISEASE EFFECTS ON TRANSPORTER EXPRESSION -- SUMMARY -- References -- 2 - Regulation of Drug-Metabolizing Enzymes and Drug Metabolism by Inflammatory Responses -- INTRODUCTION -- THE INFLAMMATORY RESPONSE -- Initiation of an Inflammatory Response -- Propagation of the Inflammatory Signal -- Cytokines and Acute Phase Proteins -- Cytokine Regulation of APP Genes -- Interleukin-6 -- Interleukin-1 -- TUMOR NECROSIS FACTOR α -- Innate Immune Response in the Liver -- REGULATION OF DMES BY INFLAMMATORY MEDIATORS -- TLR Ligands -- Toll-Like Receptor 4 -- Toll-Like Receptor 2 -- Toll-Like Receptor 3 -- Proinflammatory Cytokines -- Caveats to Primary Hepatocyte Work -- Participation of Cytokines in DME Regulation In Vivo -- INTERLEUKIN-6 -- TUMOR NECROSIS FACTOR α -- INTERLEUKIN-1β -- Other Cytokines -- REGULATION OF P450 ENZYMES IN SPECIFIC DISEASE STATES AND MODELS -- Liver Disease -- Viral Infections -- Influenza -- Human Immunodeficiency Virus -- Hepatitis C Virus -- Hepatitis B Virus -- Hepatitis A Virus -- Bacterial Infections -- Sepsis -- Helicobacter pylori -- Parasitic Infections -- Malaria -- Schistosomiasis -- Leishmaniasis -- Liver Flukes -- Amebiasis. , Sterile Inflammation -- Vaccination -- Arthritis -- Cancer -- Lupus Erythematosus -- Behçet Disease -- Critical Illness -- Congestive Heart Failure -- Bone Marrow Transplantation -- DISEASE-DEPENDENT DRUG-DRUG INTERACTIONS -- MECHANISMS OF REGULATION -- Transcriptional Mechanisms -- Direct Repression via Negative Response Elements -- Downregulation of Positive Transcription Factors -- Inhibitory Binding to Positive Transcription Factors -- Induction Mechanisms -- Epigenetic Mechanisms -- Posttranscriptional Mechanisms -- Nitric Oxide -- MicroRNAs -- CONCLUSION -- References -- 3 - Regulation of Drug Transporters by Inflammation -- INTRODUCTION -- ACUTE INFLAMMATION -- MODELS OF ACUTE INFLAMMATION -- EFFECT OF ACUTE INFLAMMATION ON DRUG TRANSPORTERS -- ABC Efflux Transporters -- P-Glycoprotein (MDR1/ABCB1) -- LIVER -- INTESTINE -- KIDNEY -- BRAIN -- PLACENTA -- Breast Cancer Resistance Protein (BCRP/ABCG2) -- LIVER -- INTESTINE -- BRAIN -- PLACENTA -- Multidrug Resistance-Associated Proteins -- LIVER -- OTHER TISSUES -- Bile Salt Export Pump (BSEP/ABCB11) -- Solute Carrier Uptake Transporting Family -- LIVER -- KIDNEY -- PLACENTA -- CHRONIC INFLAMMATION -- IMPACT OF CHRONIC INFLAMMATION ON DRUG TRANSPORTERS -- Rheumatoid Arthritis -- Inflammatory Bowel Disease -- Chronic Renal Failure -- Cholestasis -- CONCLUSION -- References -- 4 - Drug Metabolism in Kidney Disease -- CONVENTIONAL DRUG-DOSING PARADIGM IN KIDNEY DISEASE -- NONRENAL CLEARANCE -- INFLUENCE OF EXPERIMENTAL KIDNEY DISEASE ON DRUG METABOLISM -- Metabolism in Experimental Models of Chronic Kidney Disease -- Metabolism in Experimental Models of Acute Kidney Injury (Acute Renal Failure) -- INFLUENCE OF KIDNEY DISEASE ON DRUG METABOLISM IN HUMANS -- Altered Nonrenal Clearance -- Phenotypic Assessments of Metabolic Pathways in Kidney Disease. , MECHANISMS OF ALTERED DRUG METABOLISM IN KIDNEY DISEASE -- Modified Gene or Protein Expression -- Posttranslational Modifications (Direct Competitive Inhibition) -- SUMMARY -- References -- 5 - Drug and Fatty Acid Cytochrome P450 Metabolism in Critical Care -- INTRODUCTION -- STROKE -- TRAUMATIC BRAIN INJURY -- CARDIAC ARREST -- SUMMARY -- References -- 6 - Drug Metabolism in Cardiovascular Disease -- INTRODUCTION -- CARDIOVASCULAR DISEASES -- Heart Failure -- Cardiorenal Syndrome -- Cardiohepatic Syndrome -- Cardiac Arrest -- Therapeutic Hypothermia -- CYTOCHROME P-450 EXPRESSION IN CARDIOVASCULAR DISEASE -- PHARMACOGENOMICS RELATED TO CARDIOVASCULAR DRUGS AND DISEASE -- Variation in Drug Metabolism -- Heart Failure and Hypertension -- β-Blockers and CYP2D6 -- Angiotensin Receptor Blockers and CYP2C9 -- Digoxin and ATP-Binding Cassette B1 -- Acute Coronary Syndrome and Percutaneous Coronary Intervention -- Clopidogrel and CYP2C19 -- Thromboembolism -- Warfarin and CYP2C9, VKORC1 -- Dabigatran and Carboxylesterase-1 -- Dyslipidemia -- HMG-CoA Reductase Inhibitors and SLCO1B1 -- CONCLUSION -- References -- 7 - Pharmacogenetic Factors That Affect Drug Metabolism and Efficacy in Type 2 Diabetes Mellitus -- INTRODUCTION -- SULFONYLUREAS -- Mechanism -- Mutations in Drug-Metabolizing Enzyme Coding Genes -- Mutations in Other Genes -- MEGLITINIDES -- Mechanism -- Mutations in Drug-Metabolizing Enzyme Coding Genes -- Mutations in Drug Transporter Coding Genes -- Mutations in the Other Genes -- METFORMIN -- Mechanism -- Mutations in Drug Transporter Coding Genes -- Mutations in the Other Genes -- THIAZOLIDINEDIONES -- Mechanism -- Mutations in Drug-Metabolizing Enzyme Coding Genes -- Mutations in Drug Transporter Coding Genes -- Mutations in the Other Genes -- α-GLUCOSIDASE INHIBITORS -- DPP-4 INHIBITORS -- CONCLUSION -- References. , 8 - Hepatic Drug Metabolism in Pediatric Patients -- ONTOGENY OF HEPATIC DRUG METABOLISM -- ONTOGENY OF INTRINSIC HEPATIC CLEARANCE -- Ontogeny of Hepatic CYP Enzymes -- CYP1A -- CYP2A -- CYP2B -- CYP2C -- CYP2D -- CYP2E -- CYP3A -- Ontogeny of Hepatic UGT Enzymes -- ONTOGENY OF HEPATIC BLOOD FLOW -- ONTOGENY OF PLASMA PROTEIN BINDING -- ONTOGENY OF HEPATIC DRUG TRANSPORTERS -- CONCLUSION -- References -- 9 - Drug Metabolism in Pregnancy -- INTRODUCTION -- PHYSIOLOGICAL ADAPTATIONS DURING PREGNANCY -- Hemodynamics, Hematology, and Hemodilution -- Respiratory -- Renal Blood Flow and Filtration -- Gastrointestinal Function -- HEPATIC PHASE I ENZYMES -- Cytochrome P450 Enzymes -- Carboxylesterase and Paraoxanase Enzymes -- HEPATIC PHASE II ENZYMES -- Ugts -- Gsts -- Sults -- HEPATIC TRANSPORTERS -- Solute Carrier (SLC) Transporters -- ATP-Binding Cassette Transporters -- NUCLEAR RECEPTORS -- HORMONAL REGULATION -- Estrogen -- Progesterone -- Placental Lactogen/Prolactin/Growth Hormone -- Cortisol -- EXTRAHEPATIC REGULATION -- CASE EXAMPLE: BILE ACID METABOLISM AND TRANSPORT -- Phase I -- Phase II -- Transport -- Transcription Factors -- Translational Implications -- CONCLUSION AND FUTURE DIRECTIONS -- References -- 10 - Estrogen-Metabolizing Enzymes in Systemic and Lo -- ESTROGEN SULFOTRANSFERASE AND STEROID SULFATASE IN ESTROGEN HOMEOSTASIS: AN INTRODUCTION -- ESTROGEN SULFOTRANSFERASE AND ITS REGULATION IN SEPSIS RESPONSE -- ESTROGEN SULFOTRANSFERASE AND ITS REGULATION IN LIVER ISCHEMIA AND REPERFUSION RESPONSE -- STEROID SULFATASE AND ITS REGULATION IN ESTROGEN HOMEOSTASIS AND INFLAMMATION IN CHRONIC LIVER DISEASE -- CONCLUSIONS AND PERSPECTIVES -- Acknowledgment -- References -- 11 - Xenobiotic Receptors in the Crosstalk Between Drug Metabolism and Energy Metabolism -- INTRODUCTION -- XENOBIOTIC RECEPTORS AS MASTER REGULATORS OF DRUG METABOLISM. , Discovery of Aryl Hydrocarbon Receptor -- Discovery of Pregnane X Receptor and Constitutive Androstane Receptor -- DRUG METABOLISM CAN BE AFFECTED BY ENERGY METABOLISM -- Effect of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis on Drug Metabolism -- Effect of Diabetes and Insulin Resistance on Drug Metabolism -- Effect of Circadian Clock and Feeding-Fasting Switch on Drug Metabolism -- ENERGY METABOLISM CAN BE AFFECTED BY DRUG METABOLISM AND XENOBIOTIC RECEPTORS -- Aryl Hydrocarbon Receptor in Energy Metabolism -- Pregnane X Receptor and Constitutive Androstane Receptor in Energy Metabolism -- Pregnane X Receptor and Constitutive Androstane Receptor in Lipid Metabolism -- Pregnane X Receptor and Constitutive Androstane Receptor in Glucose Metabolism and Insulin Resistance -- Pregnane X Receptor and Constitutive Androstane Receptor in Lipoprotein Homeostasis -- CONCLUSION AND PERSPECTIVES -- References -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- K -- L -- M -- N -- O -- P -- R -- S -- T -- U -- V -- W -- X -- Z -- Back Cover.

Additional Edition: ISBN 0-12-802949-8

Language: English

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Format: 1 online resource (xxii, 330 pages, 8 unnumbered pages of plates) : , illustrations (some color)

ISBN: 9780470409107 , 047040910X , 9780470409053 , 0470409053 , 1281938688 , 9781281938688

Content: Providing an updated and expert overview of nuclear hormone receptors in drug metabolism and drug development, this book equips drug development scientists with an interdisciplinary understanding of these receptors and how to regulate them. This aids in pharmaceutical research to target drugs and treat diseases like cancer, coronary heart disease, and diabetes. A single source for researchers, this book collects material otherwise scattered among journals, and adds background and applications data to make the chapters more comprehensive.

Note: Drug metabolism : significance and challenges -- Establishing orphan nuclear receptors PXR and CAR as xenobiotic receptors -- Nuclear receptor-mediated regulation of phase II conjugating enzymes -- Nuclear receptor-mediated regulation of drug transporters -- Structure and function of PXR and CAR -- Xenobiotic receptor cofactors and coregulators -- Animal models of xenobiotic nuclear receptors and their utility in drug development -- Nuclear receptors and drug-drug interactions of prescription drugs and herbal medicines -- Genetic variants of xenobiotic receptors and their implications in drug metabolism and pharmacogenetics -- Beyond PXR and CAR, regulation of xenobiotic metabolism by other nuclear receptors -- Emerging role of retinoid-related orphan receptor (ROR) and its cross talk with LXR (liver X receptor) in the regulation of drug-metabolizing enzymes.

Additional Edition: Print version: Nuclear receptors in drug metabolism. Hoboken, NJ : John Wiley & Sons, ©2009 ISBN 0470086793

Additional Edition: ISBN 9780470086797

Language: English

Keywords: Electronic books. ; Electronic books. ; Electronic books.

DOI: 10.1002/9780470409107

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9780470409107

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9780470409107

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9780470409107

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Format: 321 Seiten , Karten , 30 cm

Original writing title: 印度古文明 : 藝術特展

Original writing title: 印度古文明 : 艺术特展

Original writing publisher: 臺北市 : 國立歷史博物館

Original writing publisher: 台北市 : 国立历史博物馆

ISBN: 9570139285 , 9789570139280

Note: Katalog der gleichnamigen Ausstellung im National Museum of History, Taipei, 23.4. - 20.7.2003 , Errata slip inserted , Includes bibliographical references , In chinesischer und englischer Sprache

Language: Chinese

Subjects: Art History

Keywords: Bildband ; Ausstellungskatalog

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Format: 110 p , col. ill , 30 cm

Original writing title: 世態與流風 : 台灣早期服飾與傅子菁的對話 = Style and fashion

Original writing title: 世态与流风 : 台湾早期服饰与傅子菁的对话 = Style and fashion

Original writing publisher: 臺北市 : 國立歷史博物館

Original writing publisher: 台北市 : 国立历史博物馆

ISBN: 9570107448 , 9789570107449

Note: "Shi jian: 2002.3.13 - 4.21, di dian: Guo li li shi bo wu guan yi lou, 101, 102 zhan ting , "Zhu ban dan wei Guo li li shi bo wu guan ; xie ban dan wei she ji shi Fu Zijing , Includes bibliographical references , Preface also in English

Language: Chinese

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Format: Online-Ressource

Original writing title: 山西文史资料 : 第十五辑

Language: Chinese

URL: Volltext

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Format: Online-Ressource

Original writing title: 张问安诗选

Language: Chinese

URL: Volltext

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Format: Online-Ressource

Original writing title: 遂昌文史资料 : 遂昌茶业史话, 第九辑

Language: Chinese

URL: Volltext

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Format: Online-Ressource

Original writing title: 玉环文史资料 : 水果专辑, 第十七辑

Note: 建国后史料之五

Language: Chinese

URL: Volltext

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Format: Online-Ressource

Original writing title: 通衢 : 衢州文史丛书

ISBN: 7104009736

Series Statement: Qu Zhou Wen Shi Cong Shu

Language: Chinese

URL: Volltext