Format:
Online-Ressource
Edition:
Online-Ausg.
ISBN:
1619428970
,
9781619428973
Content:
Intro -- THE ROLE OF OXIDATIVE STRESS, MITOCHONDRIA FAILURE, AND CELLULAR HYPOPERFUSION IN THE CONTEXT OF ALZHEIMER DISEASE -- THE ROLE OF OXIDATIVE STRESS, MITOCHONDRIA FAILURE, AND CELLULAR HYPOPERFUSION IN THE CONTEXT OF ALZHEIMER DISEASE -- Dedication and Acknowledgments -- Contents -- Preface -- Are Mitochondrial Failures a Key Component in Alzheimer Disease? -- Abstract -- Acknowledgments -- References -- In Vivo and In Vitro Assessment of the Brain Mitochondrial Bioenergetics in Aging Rats -- Abstract -- Introduction -- Materials and Methods -- Animals -- Methods -- In vivo 31P Magnetic Resonance Spectroscopy -- In Vitro Mitochondrial Respiration -- In Vitro Mitochondrial Oxidative Phosphorylation (Table 2 and Figure 2) -- Endogenous Antioxidants -- Statistical Methods -- Results -- In Vivo 31P Magnetic Resonance Spectroscopy -- Endogenous Antioxidants (Table 3 and Figure 3) -- Discussion -- Acknowledgments -- References -- The Pathophysiology of Cerebrovascular Lesions in Alzheimer Disease -- Abstract -- The Effect of Oxidative Stress on Brain Microvessel Function in AD -- Neuropathologic Features of Cerebrovascular Lesions -- Hypoperfusion as a Factor in the Development of AD -- Relationships between Apolipoprotein E (ApoE) Genotype, Hypercholesterolemia, and Vascular Changes in AD -- Hypoxia/Ischemia/Reperfusion as Cofactors for Oxidative Stress Induced Cerebrovascular Lesions and their Relationship to AD -- The Role of Mitochondrial Abnormalities in the Patho-Genesis of Oxidative Stress-Induced Brain Lesions in AD -- The Role of Endothelial Vasoactive Substancesin the Pathophysiology of Brain Ischemia/Reperfusion and AD -- Transgenic Animals as Models for Studying Cerebrovascular Lesions in AD -- Prevention of AD Using Selective Pharmacological Treatments -- Conclusion and Considerations for the Future -- Acknowledgments.
Note:
Includes index
Additional Edition:
9781619428782
Additional Edition:
Erscheint auch als Druck-Ausgabe Role of Oxidative Stress, Mitochondria Failure, and Cellular Hypoperfusion in the Context of Alzheimer Disease : Past, Present and Future
Language:
English
URL:
Volltext
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