Psychiatry Research, August 15, 2014, Vol.218(1-2), p.101(5)
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.psychres.2014.04.013 Byline: Akiko Nagane, Hajime Baba, Yoshiyuki Nakano, Hitoshi Maeshima, Mana Hukatsu, Kazuhiro Ozawa, Toshihito Suzuki, Heii Arai Abstract: Patients with major depressive disorder (MDD) are known to present with cognitive deficits; however, the presence of these deficits in the remitted state have been inconsistent. One of the most important factors potentially contributing to inconsistencies between studies may be the influence of medications. To explore the influence of antidepressants on cognitive performance in remitted MDD, we evaluated memory and executive functions using Wechsler Memory Scale-Revised and Stroop Color and Word Test, and compared performance among 50 medicated (29 treated with tricyclic antidepressants [TCA], 21 treated with selective serotonin reuptake inhibitors or serotonin noradrenalin reuptake inhibitors) and 19 medication-free MDD patients and 31 controls. The results showed that all 3 MDD groups had significantly lower performance for verbal memory compared with controls. Both medicated groups showed significantly lower performance for visual memory compared with controls; however, the medication-free group did not differ from controls. For the executive function, only the TCA group showed a significantly lower performance compared with controls. These results suggest that cognitive impairment remained even in remitted patients with MDD, however, part of this impairment may be influenced by class-specific antidepressant side effects. Author Affiliation: (a) Juntendo University Mood Disorder Project (JUMP), Department of Psychiatry, Juntendo Koshigaya Hospital, Saitama, Japan (b) Shumeikai Minami-saitama Hospital, Saitama, Japan (c) Shumeikai Izumi Clinic, Saitama, Japan (d) Department of Psychiatry, Juntendo University, School of Medicine, Tokyo, Japan Article History: Received 12 August 2013; Revised 6 December 2013; Accepted 6 April 2014
Drugs -- Comparative Analysis ; Tricyclic Antidepressants -- Comparative Analysis ; Medical Research -- Comparative Analysis ; Major Depressive Disorder -- Comparative Analysis
Cengage Learning, Inc.