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  • 1
    In: Fachanwalt Arbeitsrecht, 01/1/2015, Vol.19(9)
    ISSN: 1434-4602
    E-ISSN: 2366-066X
    Source: Walter de Gruyter (via CrossRef)
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  • 2
    In: PLoS ONE, 2015, Vol.10(6)
    Description: In witnessing face-to-face conversation, observers perceive authentic communication according to the social contingency of nonverbal feedback cues (‘back-channeling’) by non-speaking interactors. The current study investigated the generality of this function by focusing on nonverbal communication in musical improvisation. A perceptual experiment was conducted to test whether observers can reliably identify genuine versus fake (mismatched) duos from musicians’ nonverbal cues, and how this judgement is affected by observers’ musical background and rhythm perception skill. Twenty-four musicians were recruited to perform duo improvisations, which included solo episodes, in two styles: standard jazz (where rhythm is based on a regular pulse) or free improvisation (where rhythm is non-pulsed). The improvisations were recorded using a motion capture system to generate 16 ten-second point-light displays (with audio) of the soloist and the silent non-soloing musician (‘back-channeler’). Sixteen further displays were created by splicing soloists with back-channelers from different duos. Participants (N = 60) with various musical backgrounds were asked to rate the point-light displays as either real or fake. Results indicated that participants were sensitive to the real/fake distinction in the free improvisation condition independently of musical experience. Individual differences in rhythm perception skill did not account for performance in the free condition, but were positively correlated with accuracy in the standard jazz condition. These findings suggest that the perception of back-channeling in free improvisation is not dependent on music-specific skills but is a general ability. The findings invite further study of the links between interpersonal dynamics in conversation and musical interaction.
    Keywords: Research Article
    E-ISSN: 1932-6203
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  • 3
    Language: English
    In: PLoS ONE, 2010, Vol.5(3), p.e9437
    Description: Universally conserved positions in ribosomal proteins have significant biases in amino acid usage, likely indicating the expansion of the genetic code at the time leading up to the most recent common ancestor(s) (MRCA). Here, we apply this principle to the evolutionary history of the ribosome before the MRCA. It has been proposed that the experimentally determined order of assembly for ribosomal subunits recapitulates their evolutionary chronology. Given this model, we produce a probabilistic evolutionary ordering of the universally conserved small subunit (SSU) and large subunit (LSU) ribosomal proteins. Optimizing the relative ordering of SSU and LSU evolutionary chronologies with respect to minimizing differences in amino acid usage bias, we find strong compositional evidence for a more ancient origin for early LSU proteins. Furthermore, we find that this ordering produces several trends in specific amino acid usages compatible with models of genetic code evolution.
    Keywords: Research Article ; Biochemistry -- Macromolecular Assemblies And Machines ; Evolutionary Biology -- Bioinformatics ; Molecular Biology -- Molecular Evolution
    E-ISSN: 1932-6203
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  • 4
    In: Medicine & Science in Sports & Exercise, 2016, Vol.48(5S Suppl 1), pp.518-518
    ISSN: 0195-9131
    Source: Copyright © 2013 Lippincott Williams & Wilkins. All rights reserved.〈img src=http://exlibris-pub.s3.amazonaws.com/LWW%20logo.png style="vertical-align:middle;margin-left:7px"〉
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  • 5
    Language: English
    In: European Journal of Pediatrics, 2014, Vol.173(10), pp.1399-1403
    Description: Farber disease (FD) is a lysosomal storage disorder caused by accumulation of ceramide in various organs and tissues, most notably the central nervous system, subcutaneous tissues and respiratory tract. We report a girl who developed major destructive bone involvement, which affected the odontoid process and produced spinal compression at 9 years of age. Bone involvement was proven histologically but resolved, as assessed by serial MRI scanning, following matched unrelated donor haematopoietic stem cell transplantation. This transplant resulted in only partial donor chimerism (less than 10 % donor cells in peripheral blood), yet this was sufficient to almost normalize acid ceramidase levels in leukocytes and to produce dramatic improvements in subcutaneous nodules and joint mobility as well as the beneficial effect on the involved bone. Unfortunately, the transplant was rejected after 2 years but the patient was rescued from an aplastic state by successful haploidentical peripheral blood stem cell transplantation and remained a full donor chimera without recurrence of the bone involvement and with steadily improving mobility at the age of 17 years. We describe an FD patient who presented with severe destruction of the odontoid by inflammatory tissue which was reversed after long-term control achieved by allogeneic hematopoietic stem cell transplantation. After extensive literature search, we believe that this is the first report of bony involvement in Farber disease.
    Keywords: Acid ceramidase ; Farber disease ; Bone involvement ; Hematopoietic stem cell transplantation
    ISSN: 0340-6199
    E-ISSN: 1432-1076
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  • 6
    Language: German
    In: Pharmazie in unserer Zeit, May 2012, Vol.41(3), pp.222-7
    Keywords: Stem Cell Transplantation ; Precursor Cell Lymphoblastic Leukemia-Lymphoma -- Therapy
    E-ISSN: 1615-1003
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 7
    Language: German
    In: Pharmazie in unserer Zeit, May 2012, Vol.41(3), pp.222-227
    Description: Die akute lymphatische Leukämie (ALL) des Kindesalters ist eine Erkrankung, bei der die Wahrscheinlichkeit des Überlebens (pOS = ) heute um 0,85 und die Wahrscheinlichkeit des ereignisfreien Überlebens (pEFS = ) 0,78 beträgt; solche Daten werden nicht nur von der BFM‐Gruppe, sondern auch von der St. Jude Group berichtet.
    ISSN: 0048-3664
    E-ISSN: 1615-1003
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  • 8
    Language: English
    In: 2012, Vol.7(12), p.e50248
    Description: Reconstitution of cytomegalovirus-specific CD3 + CD8 + T cells (CMV-CTLs) after allogeneic hematopoietic stem cell transplantation (HSCT) is necessary to bring cytomegalovirus (CMV) reactivation under control. However, the parameters determining protective CMV-CTL reconstitution remain unclear to date. ; In a prospective tri-center study, CMV-CTL reconstitution was analyzed in the peripheral blood from 278 patients during the year following HSCT using 7 commercially available tetrameric HLA-CMV epitope complexes. All patients included could be monitored with at least CMV-specific tetramer. ; CMV-CTL reconstitution was detected in 198 patients (71%) after allogeneic HSCT. Most importantly, reconstitution with 1 CMV-CTL per µl blood between day +50 and day +75 post-HSCT discriminated between patients with and without CMV reactivation in the R+/D+ patient group, independent of the CMV-epitope recognized. In addition, CMV-CTLs expanded more daramtaically in patients experiencing only one CMV-reactivation than those without or those with multiple CMV reactivations. Monitoring using at least 2 tetramers was possible in 63% (n = 176) of the patients. The combinations of particular HLA molecules influenced the numbers of CMV-CTLs detected. The highest CMV-CTL count obtained for an individual tetramer also changed over time in 11% of these patients (n = 19) resulting in higher levels of HLA-B*0801 (IE-1) recognizing CMV-CTLs in 14 patients. ; Our results indicate that 1 CMV-CTL per µl blood between day +50 to +75 marks the beginning of an immune response against CMV in the R+/D+ group. Detection of CMV-CTL expansion thereafter indicates successful resolution of the CMV reactivation. Thus, sequential monitoring of CMV-CTL reconstitution can be used to predict patients at risk for recurrent CMV reactivation.
    Keywords: Research Article ; Biology ; Medicine ; Immunology ; Infectious Diseases ; Hematology ; Oncology
    E-ISSN: 1932-6203
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  • 9
    Language: English
    In: PLoS ONE, 2011, Vol.6(11), p.e27351
    Description: In an ongoing clinical phase I/II study, 16 pediatric patients suffering from high risk leukemia/tumors received highly purified donor natural killer (NK) cell immunotherapy (NK-DLI) at day (+3) +40 and +100 post haploidentical stem cell transplantation. However, literature about the influence of NK-DLI on recipient's immune system is scarce. Here we present concomitant results of a noninvasive in vivo monitoring approach of recipient's peripheral blood (PB) cells after transfer of either unstimulated (NK-DLI (unstim) ) or IL-2 (1000 U/ml, 9–14 days) activated NK cells (NK-DLI (IL-2 stim) ) along with their ex vivo secreted cytokine/chemokines. We performed phenotypical and functional characterizations of the NK-DLIs, detailed flow cytometric analyses of various PB cells and comprehensive cytokine/chemokine arrays before and after NK-DLI. Patients of both groups were comparable with regard to remission status, immune reconstitution, donor chimerism, KIR mismatching, stem cell and NK-DLI dose. Only after NK-DLI (IL-2 stim) was a rapid, almost complete loss of CD56 (bright) CD16 (dim/−) immune regulatory and CD56 (dim) CD16 (+) cytotoxic NK cells, monocytes, dendritic cells and eosinophils from PB circulation seen 10 min after infusion, while neutrophils significantly increased. The reduction of NK cells was due to both, a decrease in patients' own CD69 (−) NCR (low) CD62L (+) NK cells as well as to a diminishing of the transferred cells from the NK-DLI (IL-2 stim) with the CD56 (bright) CD16 (+/−) CD69 (+) NCR (high) CD62L (−) phenotype. All cell counts recovered within the next 24 h. Transfer of NK-DLI (IL-2 stim) translated into significantly increased levels of various cytokines/chemokines (i.e. IFN-γ, IL-6, MIP-1β) in patients' PB. Those remained stable for at least 1 h, presumably leading to endothelial activation, leukocyte adhesion and/or extravasation. In contrast, NK-DLI (unstim) did not cause any of the observed effects. In conclusion, we assume that the adoptive transfer of NK-DLI (IL-2 stim) under the influence of ex vivo and in vivo secreted cytokines/chemokines may promote NK cell trafficking and therefore might enhance efficacy of immunotherapy.
    Keywords: Research Article ; Biology ; Medicine ; Immunology ; Hematology ; Oncology ; Pediatrics And Child Health
    E-ISSN: 1932-6203
    Source: PLoS
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  • 10
    Language: English
    In: Journal of clinical microbiology, August 2015, Vol.53(8), pp.2605-10
    Description: While the assessment of β-D-glucan (BDG) levels in adults improves the early diagnosis of invasive fungal disease (IFD), data on BDG levels in children are limited. We therefore assessed in a prospective cohort study the value of serial BDG screening for early detection of IFD in children undergoing allogeneic hematopoietic stem cell transplantation (HSCT). IFD was defined according to the revised European Organization for Research and Treatment of Cancer/Mycosis Study Group (EORTC/MSG) criteria, with the necessary modification that BDG was not included as a microbiological criterion. For the analysis, a total of 702 serum samples were obtained in 34 pediatric HSCT recipients. Proven IFD occurred in two patients (fusariosis and Candida sepsis, respectively), and probable invasive aspergillosis was diagnosed in four patients. Analyses including different cutoff values for BDG levels and different definitions of the onset of IFD demonstrated that the BDG assay has a relatively high sensitivity and good negative predictive value, whereas the positive predictive value has major limitations (〈30%). Receiver operating characteristic analyses suggested an optimal cutoff between 60 and 70 pg/ml for different definitions of the onset of IFD. Our data show that BDG screening in pediatric HSCT recipients has a low positive predictive value and is therefore of limited usefulness.
    Keywords: Diagnostic Tests, Routine -- Methods ; Hematopoietic Stem Cell Transplantation -- Adverse Effects ; Mass Screening -- Methods ; Mycoses -- Diagnosis ; Transplantation, Homologous -- Adverse Effects ; Beta-Glucans -- Analysis
    ISSN: 00951137
    E-ISSN: 1098-660X
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