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  • 1
    Online Resource
    Online Resource
    Basel, Switzerland : MDPI - Multidisciplinary Digital Publishing Institute
    UID:
    gbv_1794568735
    Format: 1 Online-Ressource (318 p.)
    ISBN: 9783036523705 , 9783036523699
    Content: Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of chronic kidney disease in the sequel. Whereas the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function—in both the short- and long-term—is urgently needed. This Special Issue includes papers investigating the pathological mechanisms of renal inflammation and AKI and diagnostics using new biomarkers. Furthermore, experimental in vitro and in vivo studies examining potential new approaches to attenuate kidney dysfunction are included, as well as review articles
    Note: English
    Language: English
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  • 2
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : MDPI - Multidisciplinary Digital Publishing Institute
    UID:
    gbv_1778455565
    Format: 1 Online-Ressource (496 p.)
    ISBN: 9783039285389 , 9783039285396
    Content: Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of subsequent chronic kidney disease. Although the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function is urgently needed. The Special Issue covers research articles that investigated the molecular mechanisms of inflammation and injury during different renal pathologies, renal regeneration, diagnostics using new biomarkers, and the effects of different stimuli like medication or bacterial components on isolated renal cells or in vivo models. The Special Issue contains important reviews that consider the current knowledge of cell death and regeneration, inflammation, and the molecular mechanisms of kidney diseases. In addition, the potential of cell-based therapy approaches that use mesenchymal stromal/stem cells or their derivates is summarized. This edition is complemented by reviews that deal with the current data situation on other specific topics like diabetes and diabetic nephropathy or new therapeutic targets
    Note: English
    Language: English
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  • 3
    Online Resource
    Online Resource
    Basel, Switzerland : MDPI - Multidisciplinary Digital Publishing Institute
    UID:
    gbv_1778434614
    Format: 1 Online-Ressource (286 p.)
    ISBN: 9783039432820 , 9783039432837
    Content: Adipose tissue is a rich, ubiquitous, and easily accessible source for multipotent mesenchymal stromal/stem cells (MSCs), so-called adipose-derived stromal/stem cells (ASCs). Primary isolated ASCs are a heterogeneous preparation consisting of several subpopulations of stromal/stem and precursor cells. Donor-specific differences in ASC isolations and the lack of culture standardization hinder the comparison of results from different studies. Nevertheless, ASCs are already being used in different in vivo models and clinical trials to investigate their ability to improve tissue and organ regeneration. Many questions concerning their counterparts and biology in situ, their differentiation potential in vitro and in vivo, and the mechanisms of regeneration (paracrine effects, including regeneration-promoting factors and extracellular vesicles, differentiation, and immunomodulation) are not completely understood or remain unanswered. This Special Issue covers research articles investigating various adipose tissues as a source for ASC isolation, specific cultures methods to enhance proliferation or viability, and the differentiation capacity. Furthermore, other studies highlight aspects of various diseases, the immunosuppressive potential of ASCs and their derivates, or the in vivo tracking of transplanted ASCs. This edition is complemented by a review that summarizes the current knowledge of spheroid culture system methods and applications for mesenchymal stem cells
    Note: English
    Language: English
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  • 4
    UID:
    b3kat_BV048251923
    Format: 1 Online-Ressource
    ISBN: 9783036523699
    Content: Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of chronic kidney disease in the sequel. Whereas the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function—in both the short- and long-term—is urgently needed. This Special Issue includes papers investigating the pathological mechanisms of renal inflammation and AKI and diagnostics using new biomarkers. Furthermore, experimental in vitro and in vivo studies examining potential new approaches to attenuate kidney dysfunction are included, as well as review articles.
    Additional Edition: Erscheint auch als Druck-Ausgabe, Hardcover ISBN 978-3-0365-2370-5
    Language: English
    URL: Volltext  (kostenfrei)
    URL: Volltext  (kostenfrei)
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  • 5
    Online Resource
    Online Resource
    Basel ; Beijing ; Wuhan ; Barcelona ; Belgrade ; Manchester ; Tokyo ; Cluj ; Tianjin : MDPI
    UID:
    b3kat_BV046870707
    Format: 1 Online-Ressource
    ISBN: 9783039285396
    Additional Edition: Erscheint auch als Druck-Ausgabe, Paperback ISBN 978-3-03928-538-9
    Language: English
    URL: Volltext  (kostenfrei)
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  • 6
    UID:
    b3kat_BV026474357
    Format: VII, 139, XII S. , Ill., graph. Darst.
    Edition: [Mikrofiche-Ausg.]
    Edition: Mikroform-Ausgabe Marburg Tectum-Verl. 1999 2 Mikrofiches : 24x Edition Wissenschaft : Reihe Biologie ; 183 Mikrofiche-Ausg.:
    ISBN: 3828807143
    Note: Zugl.: Frankfurt (Main), Univ., Diss., 1999
    Additional Edition: Reproduktion von Baer, Patrick C. Isolierung und Charakterisierung humaner renaler proximaler und distaler Tubuluszellen: Etablierung eines In-vitro-Modells 1999
    Language: German
    Keywords: Nierentubulus ; Epithelzelle ; Zellfraktionierung ; Enzyme-linked immunosorbent assay ; Hochschulschrift
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  • 7
    Online Resource
    Online Resource
    Basel : MDPI - Multidisciplinary Digital Publishing Institute
    UID:
    gbv_1877754692
    Format: 1 Online-Ressource (218 p.)
    ISBN: 9783036592183 , 9783036592190
    Content: The recovery of cells after tissue and organ injury is a complex process, more detailed insights into the cellular processes of repair and regeneration are urgently needed if we are to understand underlying molecular biological mechanisms. Based on this knowledge, this Special Issue will focus on current in vitro systems exploring repair and regeneration mechanisms. As such, this SI includes experimental research approaches to investigate the mechanisms involved and laboratory methods to establish and optimise models for tissue and organ repair and regeneration, theoretical modelling and computational models, as well as review papers are included here. Eleven articles are published in the Special Issue, which deals with various tissue and organ regeneration questions or the modelling or summary of the research models used in this process
    Note: English
    Language: Undetermined
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  • 8
    Online Resource
    Online Resource
    Basel : MDPI
    UID:
    b3kat_BV049597949
    Format: 1 Online-Ressource (vii, 208 Seiten) , Illustrationen, Diagramme
    ISBN: 9783036592190
    Note: Special issue reprint "International Journal of Molecular Sciences"
    Additional Edition: Erscheint auch als Druck-Ausgabe, Hardcover ISBN 978-3-0365-9218-3
    Language: English
    Keywords: Biotechnik ; Organ ; Regeneration ; Aufsatzsammlung
    URL: Volltext  (kostenfrei)
    URL: Volltext  (kostenfrei)
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