Format:
Online-Ressource (XV, 352 p. 32 illus., 13 illus. in color, digital)
ISBN:
9789400730120
,
1280787333
,
9781280787331
Series Statement:
Subcellular Biochemistry 58
Content:
John D. York
Content:
Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases - and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.
Note:
Description based upon print version of record
,
Preface; Contents; Abbreviations; Chapter 1 The Phosphatidylinositol 4-Kinases: Don't Call it a Comeback; 1.1 Introduction; 1.2 The Type II PtdIns 4-Kinases; 1.2.1 PtdIns4KII Gene Family and Domain Structure; 1.2.2 PtdIns4KII Expression, Localisation and Regulation; 1.3 The Type III PtdIns 4-Kinases; 1.3.1 Gene Family and Domain Structure; 1.3.2 PtdIns4KIII'141 Expression, Localisation and Regulation; 1.3.3 PtdIns4KIII'142 Expression, Localisation and Regulation; 1.4 Cellular Functions of PtdIns4Ks; 1.4.1 PtdIns4Ks in Signalling Pathways; 1.4.1.1 PtdIns4KIIs in Signalling Pathways
,
1.4.1.2 PtdIns4KIIIs in Signalling Pathways1.4.2 PtdIns4Ks in Intracellular Traffic; 1.4.2.1 Type II PtdIns4Ks and Intracellular Trafficking Pathways; 1.4.2.2 PtdIns4KII'141 and Endosomal Traffic; 1.4.2.3 Type III PtdIns4Ks and Membrane Traffic; 1.5 PtdIns4K Biology in the Whole Organism; 1.6 Conclusions; References; Chapter 2 PIP Kinases from the Cell Membrane to the Nucleus; 2.1 Introduction; 2.2 The Enzymes. Sequence, Structure and Enzymology; 2.2.1 Sequence and Structure of Phosphatidylinositol Phosphate Kinases; 2.2.1.1 Sequences of PIP Kinases; 2.2.1.2 PIP Kinase Structure
,
2.2.2 Enzymology of PIPKs2.3 Membrane Associated PIPKs Drive Cell Migration and Vesicle Trafficking; 2.3.1 PIPKs Help Regulate Directional Migration; 2.3.1.1 PIPKs Regulate PIP2 Synthesis at the Leading Edge to Drive Membrane Protrusion; 2.3.1.2 PIPKIg Regulates the Formation and Maturation of Integrin-mediated Contacts; 2.3.1.3 Trafficking of Integrin-containing Vesicles to the Leading Edge Is Mediated by PIPKIg and PIP2; 2.3.1.4 Rear Retraction of the Cell Requires the Dissociation and Internalization of Integrin and Acto-myosin Contractility
,
2.3.2 PIP Kinases in Adaptor Protein Complex Assembly and Protein Trafficking2.3.2.1 AP Complexes; 2.3.2.2 PIP Kinases in Regulation of AP Complex Assembly; 2.4 Nuclear Localized PIPKs Regulate Gene Expression and mRNA Processing; 2.4.1 Nuclear PIP Kinases and Phosphoinositides; 2.4.1.1 PIPKs and PIP2 at the Nuclear Envelope; 2.4.1.2 The Intra-nuclear PIPKs and PIP2; 2.4.2 Regulation and Functions of the Nuclear PIPKs; 2.4.2.1 Regulation of the Nuclear PIPKIbold0mu mumu Raw; 2.4.2.2 Regulation of the Nuclear PIPKIIbold0mu mumu bbRawbbbb/IIbold0mu mumu Raw
,
2.4.3 Downstream Signaling of the Nuclear PIPK and PIP2References; Chapter 3 The Phospholipase C Isozymes and Their Regulation; 3.1 Introduction; 3.2 Phosphoinositide-specific PLC; 3.3 Catalytic Function and Structure of Conserved Core Domains of PLC; 3.4 Mechanism of PtdIns(4,5)P2 Hydrolysis; 3.5 PLC Subfamilies and Their Regulation; 3.5.1 PLC-d Isozymes; 3.5.1.1 Regulation; 3.5.1.2 Physiology; 3.5.2 PLC-bold0mu mumu Raw Isozymes; 3.5.2.1 Regulation; 3.5.2.2 Physiology; 3.5.3 PLC-bold0mu mumu Raw Isozymes; 3.5.3.1 Regulation; 3.5.3.2 Physiology; 3.5.4 PLC-bold0mu mumu Raw; 3.5.4.1 Regulation
,
3.5.4.2 Physiology
Additional Edition:
ISBN 9789400730113
Additional Edition:
Buchausg. u.d.T. Phosphoinositides ; 1: Enzymes of synthesis and degradation Dordrecht [u.a.] : Springer, 2012 ISBN 9789400730113
Language:
English
Subjects:
Biology
Keywords:
Phosphoinositide
;
Biologischer Abbau
;
Phosphoinositide
;
Biosynthese
DOI:
10.1007/978-94-007-3012-0
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