Format:
Online-Ressource (IX, 349 p, digital)
ISBN:
9783764375676
Series Statement:
Progress in Drug Research 64
Content:
This book brings together the various fields of functional genomics and systems biology that provide information on metabolic function. There is special emphasis on the identification of drug targets. The book includes practical examples from the various 'omic' sciences as well as theoretical examples of how integrated knowledge of these sciences can be applied to drug discovery. It is of interest to researchers in the pharmaceutical drug discovery environment.
Content:
"Systems biology is an emerging discipline that studies the underlying network structure and the dynamics of metabolism, cells or whole organisms. It aims to investigate all interacting components simultaneously and requires data from high throughput techniques. These data from the ""omic"" sciences are computed and used to build in silico models of biological systems that ultimately will prove to be an invaluable tool in drug development. This book brings together the various fields of functional genomics and systems biology that provide information on metabolic function with a special emphasis on the identification of drug targets. It includes practical examples from the various ""omic"" sciences as well as theoretical examples of how integrated knowledge of these sciences can be applied to drug discovery. It is of interest to researchers in the pharmaceutical drug discovery environment, as well as those in the academic field with an interest in the functional application of the ""omic"" sciences."
Note:
Description based upon print version of record
,
CONTENTS; Foreword; Systems biology and its impact on anti-infective drug development; Applications of transcriptional profiling in antibiotics discovery anddevelopment; Chemical genetics: An evolving toolbox for target identificationand lead optimization; Proteomic profiling of cellular stresses in Bacillus subtilis revealscellular networks and assists in elucidating antibiotic mechanismsof action; Elucidating the mode-of-action of compounds from metaboliteprofiling studies; A subsystems-based approach to the identification of drug targetsin bacterial pathogens
,
Metabolic control analysis to identify optimal drug targetsThe protein network as a tool for finding novel drug targets; Toxicogenomics applied to predictive and exploratory toxicologyfor the safety assessment of new chemical entities:a long road with deep potholes; Biological robustness in complex host-pathogen systems; Toward whole cell modeling and simulation: Comprehensivefunctional genomics through the constraint-based approach; Genomics of host-pathogen interactions; Index
Additional Edition:
ISBN 9783764375669
Additional Edition:
Buchausg. u.d.T. Systems biological approaches in infectious diseases Basel : Birkhäuser, 2007 ISBN 3764375663
Additional Edition:
ISBN 9783764375669
Language:
English
Subjects:
Biology
,
Medicine
Keywords:
Infektionskrankheit
;
Epidemiologie
;
Mathematisches Modell
;
Antimikrobieller Wirkstoff
;
Arzneimittelentwicklung
;
Systembiologie
;
Infektionskrankheit
;
Epidemiologie
;
Mathematisches Modell
;
Antimikrobieller Wirkstoff
;
Arzneimittelentwicklung
;
Systembiologie
;
Aufsatzsammlung
DOI:
10.1007/978-3-7643-7567-6
URL:
Volltext
(lizenzpflichtig)
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