Format:
Online-Ressource
ISSN:
1613-4133
Content:
Abstract: Beta‐glucans and arabinoxylans are known for their immunostimulatory properties. However, in vivo these have been documented almost exclusively following parenteral administration, underemphasizing oral intake. C57BL/6 mice are fed either a control diet or a diet supplemented with yeast‐derived whole β‐glucan particle (yWGP) or with rice‐derived arabinoxylan (rice bran‐1) at a concentration of 1%, 2.5%, or 5% weight/weight (w/w) for 2 weeks. Thereafter, cells from blood, bone marrow, and spleen are collected for ex vivo stimulation with various microbial stimuli. Dietary intake of yWGP for 2 weeks at concentrations of 1% and 2.5% w/w increases ex vivo cytokine production in mouse blood and bone marrow, whereas 5% w/w yWGP shows no effect. In the spleen, cytokine production remains unaffected by yWGP. At a concentration of 1% w/w, rice bran‐1 increases ex vivo cytokine production by whole blood, but 2.5% and 5% w/w cause inhibitory effects in bone marrow and spleen. This study demonstrates that dietary yWGP and rice bran‐1 induce immune priming in mouse blood and bone marrow, with the strongest effects observed at 1% w/w. Future human trials should substantiate the efficacy of dietary β‐glucans and arabinoxylans to bolster host immunity, focusing on dose optimization.
In:
day:29
In:
month:04
In:
year:2024
In:
extent:12
In:
Molecular nutrition & food research, Weinheim : Wiley-VCH, [2004]-, (29.04.2024) (gesamt 12), 1613-4133
Language:
English
DOI:
10.1002/mnfr.202300829
URN:
urn:nbn:de:101:1-2404291458001.245713558554
URL:
https://doi.org/10.1002/mnfr.202300829
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2404291458001.245713558554
URL:
https://d-nb.info/1327863413/34
URL:
https://doi.org/10.1002/mnfr.202300829
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