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  • 1
    Language: English
    In: BJU international, June 2011, Vol.107(12), pp.1964-6
    Description: • To report our experience with a new and simple method of urethral repair with a volar onlay of free labium minus graft. Strictures of the female urethra are rare, and it is well accepted that the therapeutic options of dilation and urethrotomy are not lasting solutions as a result of their high recurrence rates. However, there is no consensus regarding the best way to reconstruct the female urethra in the case of stricture disease. • Four consecutive female patients with a long lasting history of recurrent urethral strictures underwent open urethroplasty with a volar situated free split thickness epidermal graft from the labium minus. • The surgical technique is described and a short-term follow-up is presented. • Operating time was 40-140 min (mean 105 min), and the graft measured between 2 × 1.5 cm and 3 × 2.5 cm. Follow-up time was 11-19 months. Maximum urinary flow rate could be improved from a baseline of 9.4-11.2 mL/s (preoperatively, after intermittent use of dilation) to 19-23 mL/s. • Postvoid residual urine volume was 0-50 mL preoperatively and no postvoid residual urine volume postoperatively. • Urinary catheters were removed after 21 days. Urinary stress incontinence did not occur postoperatively. No complications related to the graft donor site were found. • The reported data concerning a new therapeutic approach for the treatment of recurrent female urethral stricture show that a volar onlay urethroplasty represents a feasible, safe and simple surgical method. • Larger series with long-term follow-up are needed for further evaluation.
    Keywords: Urethra -- Surgery ; Urethral Stricture -- Surgery ; Urologic Surgical Procedures -- Methods ; Vulva -- Transplantation
    ISSN: 14644096
    E-ISSN: 1464-410X
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  • 2
    Language: English
    In: European Urology, March 2011, Vol.59(3), pp.323-324
    Keywords: Medicine
    ISSN: 0302-2838
    E-ISSN: 1873-7560
    Source: ScienceDirect Journals (Elsevier)
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  • 3
    Language: English
    In: The Journal of Urology, 2010, Vol.183(4), pp.e426-e426
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
    Source: ScienceDirect Journals (Elsevier)
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  • 4
    Language: German
    In: Info Onkologie, 2/2011, Vol.14(1), pp.24-25
    ISSN: 1613-3633
    E-ISSN: 2196-5692
    Source: Springer (via CrossRef)
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  • 5
    Language: German
    In: MMW - Fortschritte der Medizin, 5/2010, Vol.152(19), pp.43-44
    ISSN: 1438-3276
    E-ISSN: 1613-3560
    Source: Springer (via CrossRef)
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  • 6
    Language: English
    In: European Urology, October 2010, Vol.58(4), pp.514-515
    Keywords: Medicine
    ISSN: 0302-2838
    E-ISSN: 1873-7560
    Source: ScienceDirect Journals (Elsevier)
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  • 7
    Language: German
    In: MMW Fortschritte der Medizin, 13 May 2010, Vol.152(19), pp.43-4
    Keywords: Brachytherapy ; Prostatectomy ; Prostatic Neoplasms -- Therapy
    ISSN: 1438-3276
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 8
    Language: English
    In: European Urology, November 2010, Vol.58(5), pp.796-796
    Keywords: Medicine
    ISSN: 0302-2838
    E-ISSN: 1873-7560
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  • 9
    In: BJU International, October 2011, Vol.108(8b), pp.E290-E296
    Description: Study Type - Prognosis (case series) Level of Evidence4 What's known on the subject? and What does the study add? Epigenetic alterations play an essential role during carcinogenesis. While DNA methylation has been extensively studied in bladder cancer, the relevance of histone modifications remains to be clarified. Earlier studies suggested that global histone modification levels are predictive for patients' outcome in various tumour entities (e.g. prostate, lung, breast and kidney cancer). The possibility to determine global histone modification levels easily and inexpensively using immunohistochemistry increases a potential routine use in the future. Our aim was therefore to investigate the global levels of histone H3K4 and H4K20 mono-, di- and trimethylation. For this purpose we prepared tissue microarrays with non-muscle-invasive bladder cancer (NMIBC), muscle-invasive bladder cancer (MIBC), bladder cancer metastases (METS) and normal urothelium (NU) tissue to compare global H3K4 and H4K20 methylation in these tissues, as well to assess the prognostic value of histone modifications. We show that global histone modification levels (H3K4me1, H3K4me3, H4K20me1, H4K20me2, H4K20me3) are lower in bladder cancer than in NU tissue. Furthermore, there was a decrease of histone modification levels (H3K4me1, H4K20me1, H4K20me2, H4K20me3) from NU over NMIBC and MIBCto METS. Histone modifications are correlated to advanced pathological stage in NMIBC and MIBC. Furthermore, H4K20me3 appeared to be a significant and independent prognostic predictor of bladder cancer-specific survival in patients with MIBC undergoing radical cystectomy. Our findings therefore provide a rationale for further investigation of histone modifications and their manipulation in bladder cancer. times To determine the role of global histone methylation as a prognostic parameter in patients with bladder cancer. times We used a tissue microarray with samples from patients with non-muscle-invasive bladder cancer (NMIBC; n= 161), muscle-invasive bladder cancer (MIBC, n= 127), normal urothelium (NU; n= 31) and bladder cancer metastases (METS; n= 31) to determine global histone methylation (me) levels at histone H3 lysine 4 (H3K4) and H4K20. times Global histone modification levels (H3K4me1, H3K4me3, H4K20me1, H4K20me2, and H4K20me3) were lower in bladder cancersamples than in NU tissue times Global levels of H3K4me1, H4K20me1, H4K20me2 and H4K20me3 were decreasing from NU over NMIBC and MIBC to METS. times H4K20me1 levels were increased in patients with NMIBC with advanced pTstage and less differentiated bladder cancer. times In patients with MIBC, pTstage was negatively correlated with H3K4me1, H4K20me1 and H4K20me2 levels. times H4K20me3 levels were significantly correlated in a univariate and multivariate model with bladder cancer-specific mortality after radical cystectomy in patients with MIBC. times Global histone methylation levels may help to identify patients with bladder cancerwith poor prognosis after radical cystectomy.
    Keywords: Histone ; Methylation ; Bladder Cancer ; Survival ; Epigenetics ; H4k20me3
    ISSN: 1464-4096
    E-ISSN: 1464-410X
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  • 10
    Language: English
    In: The Open Prostate Cancer Journal, 05/30/2010, Vol.3(1), pp.57-62
    Description: The presence of small amounts of circulating DNA in plasma was demonstrated 60 years ago. Since then, cell-free DNA has been tested for quantity, fragmentation pattern and tumor-specific sequences in patients with various malignancies. The introduction of improved detection methods showed that all these alterations are regularly detectable in many cancer patients and the investigation of cell-free DNA may provide useful diagnostic and prognostic information. Herein, we review the recent findings on cell-free DNA alterations in patients with prostate cancer and discuss its diagnostic and prognostic potential.
    Keywords: Malignancy ; Prostate Cancer ; Nucleotide Sequence ; DNA ; Biomarkers ; Methods;
    ISSN: 18768229
    Source: Bentham Science (via CrossRef)
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