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  • 1
    In: International Journal of Game-Based Learning (IJGBL), 2011, Vol.1(1), pp.19-31
    Description: This paper outlines a simple and effective model that can be used to evaluate and design educational digital games. It also facilitates the formulation of strategies for using existing games in learning contexts. The model categorizes game goals and learning objectives into one or more of four possible categories. An overview of the model is provided and the four categories are defined. The model is used to analyze several games. The implications that this model has for the design and use of games as instructional technologies are then described.
    Keywords: Educational Games ; Video Games ; Instructional Design ; Formative Evaluation ; Summative Evaluation ; Models ; Student Educational Objectives ; Classification ; Educational Technology ; Educational Strategies;
    ISSN: 2155-6849
    E-ISSN: 21556857
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  • 2
    Language: English
    In: Neuroscience Letters, 16 May 2012, Vol.516(2), pp.306-310
    Description: ► 15% high fat diet induces hyperinsulinemia without altering glucose tolerance. ► Chronic hyperinsulinemia does not alter central Insulin receptor signaling. ► 15% high fat diet fed over 16 weeks does not change tau phosphorylation. Chronic peripheral hyperinsulinemia is one of the main characteristics of type 2 diabetes accompanied by impaired glucose homeostasis and obesity resulting from increased food intake and decreased physical activity. Patients with type 2 diabetes have a higher risk of cognitive decline and neurodegenerative diseases Alzheimer's disease (AD). Furthermore, obesity or hyperinsulinemia alone already increase the probability of cognitive decline possibly progressing to AD. Tau hyperphosphorylation is one of the pathological hallmarks of AD and so called tauopathies. Aim of the present study was to analyze the influence of obesity-associated hyperinsulinemia on tau phosphorylation without changes in glucose homeostasis. 15% high fat diet fed over 12–16 weeks induced 2.4-fold increased plasma insulin levels without changing glucose tolerance. However, this diet did not lead to substantial differences in tau phosphorylation in the brain of C57Bl/6 mice. Additionally, chronic hyperinsulinemia did not influence downstream insulin receptor signaling and the expression of the tau kinases ( ERK-1/-2, Akt, GSK-3β, CDK5 or JNK) and tau phosphatases ( PP2A) in the murine central nervous system. Thus, we successfully induced hyperinsulinemia without causing glucose intolerance in our experimental animals but this did not influence central insulin receptor signaling or tau phosphorylation.
    Keywords: Tau ; Hyperinsulinemia ; Mice ; Diabetes ; Brain ; Medicine ; Anatomy & Physiology
    ISSN: 0304-3940
    E-ISSN: 1872-7972
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  • 3
    In: British Journal of Educational Technology, May 2007, Vol.38(3), pp.478-488
    Description: In the spring of 2005, the author designed and taught a graduate‐level course on digital game‐based learning primarily for teachers. Teachers cannot be expected to embrace digital games as a tool for learning unless they have a sound understanding of the potential as well as the limitations, and are confident in their ability to use games effectively to enhance learning. The course was designed as an introduction to digital games and gaming for instruction and learning. In it, students explored the theories, the possibilities, considerations and constraints related to the design of instructional games, and the use of learning and commercial entertainment games in classroom and out‐of‐class settings. The design of the course, along with the rationales, will be outlined and participant reaction will be profiled. Suggestions for future course designs are described, as well as key elements crucial for teacher preparation. Ultimately, the success of digital games as a medium for learning depends to a large extent on the abilities of new and practicing teachers to take full advantage of this medium.
    Keywords: Teaching -- Study And Teaching ; Teachers -- Study And Teaching;
    ISSN: 0007-1013
    E-ISSN: 1467-8535
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  • 4
    Language: English
    In: Nuclear Physics, Section B, 2015, Vol.898, p.715(21)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.nuclphysb.2015.04.012 Byline: Katrin Becker, Melanie Becker, Daniel Robbins Abstract: Using an effective field theory approach and the language of SU(N)-structures, we study higher derivative corrections to the supersymmetry constraints for compactifications of string or M-theory to Minkowski space. Our analysis is done entirely in the target space and is thus very general, and does not rely on theory-dependent details such as the amount of worldsheet supersymmetry. For manifolds of real dimension n〈4 we show that internal geometry remains flat and uncorrected. For n=4,6, Kahler manifolds with SU(N)-holonomy can become corrected to SU(N)-structure, while preserving supersymmetry, once corrections are included. Author Affiliation: George P. and Cynthia W. Mitchell Institute for Fundamental Physics and Astronomy, Texas A& M University, College Station, TX 77843-4242, USA Article History: Received 16 March 2015; Accepted 14 April 2015 Article Note: (miscellaneous) Editors: Si Li and Yat Sun Poon
    Keywords: String Theory – Analysis
    ISSN: 0550-3213
    Source: Cengage Learning, Inc.
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  • 5
    Language: English
    In: Biochemical and Biophysical Research Communications, 2010, Vol.403(3), pp.368-374
    Description: ► Cystic fibrosis mice accumulate ceramide in epithelial cells of the trachea and the gut. ► Ceramide causes death of epithelial cells in the trachea and the gut. ► Ceramide triggers chronic inflammation in the trachea. ► These alterations are normalized by genetic or pharmacological inhibition of ceramide release. ► The data suggest a novel mechanism for the treatment of cystic fibrosis. Cystic fibrosis is a hereditary metabolic disorder caused by mutations of the cystic fibrosis transmembrane conductance regulator ( ) gene and characterized by severe intestinal and pulmonary symptoms, in particular intestinal obstruction, pancreatic insufficiency, chronic pulmonary inflammation, and microbial lung infections. Recent studies have demonstrated an accumulation of ceramide in the lungs of cystic fibrosis patients and in several mouse models. These findings showed that pulmonary ceramide concentrations play an important role in pulmonary inflammation and infection. In this study we investigated whether ceramide concentrations are also altered in the trachea and the intestine of cystic fibrosis mice and whether an accumulation of ceramide in these organs has functional consequences that are typical of cystic fibrosis. Our findings demonstrate a marked accumulation of ceramide in tracheal and intestinal epithelial cells of cystic fibrosis mice. When acid sphingomyelinase activity is inhibited by treating cystic fibrosis mice with amitriptyline or by genetic heterozygosity of acid sphingomyelinase in cystic fibrosis mice, ceramide concentrations in the trachea and the intestine are normalized. Moreover, increased rates of cell death and increased cytokine concentrations in the trachea, the intestine, or both were normalized by the inhibition of acid sphingomyelinase activity and the concomitant normalization of ceramide concentrations. These findings suggest that ceramide plays a crucial role in inflammation and increased rates of cell death in several organs of cystic fibrosis mice.
    Keywords: Sphingomyelinase ; Ceramide ; Cystic Fibrosis ; Inflammation ; Cell Death ; Trachea ; Intestine ; Biology ; Chemistry ; Anatomy & Physiology
    ISSN: 0006-291X
    E-ISSN: 1090-2104
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  • 6
    In: International Journal of Gaming and Computer-Mediated Simulations (IJGCMS), 2013, Vol.5(1), pp.1-12
    Description: Games use the same base technology and design strategy as do simulations, but add a few items to the mixture. Understanding this gives ‘new’ (read borrowed) tools for game creation and testing. The idea that simulations are implementations of a model, for instance, leads to a focus on the model rather than the code when designing a game. Similarly, the verification/validation pair used in simulations can be extended by adding playtesting for games, thus giving an educational game (for example) viable, demonstrable educational characteristics as well as playable (and thus engaging and motivating) characteristics. Productive work on improving games for specific purposes (serious games) can be advanced if the authors can agree on a common terminology and concept set (Shaw & Gaines, 1989), and if games can be seen as a valuable extension of a simulation that has specific characteristics that make them useful in specific circumstances. The idea of ‘fun’ is often thought of as the enemy of ‘learning’ in educational literature, and this needs to change if progress on serious and educational games is to be made. This paper will describe the hierarchy of computer simulation objects within which ludic simulations can be understood.
    Keywords: Computer Simulation Objects; Digital Objects; Games; Ludic Simulation; Simulation Game Technology
    ISSN: 1942-3888
    E-ISSN: 19423896
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  • 7
    Language: English
    In: Journal of High Energy Physics, 2015, Vol.2015(2), pp.1-18
    Description: In this note we will present a closed expression for the space-time effective action for all bosonic fields (massless and massive) obtained from the compactification of gravity or supergravity theories (such as type II or eleven-dimensional supergravities) from D to d space-time dimensions.
    Keywords: Superstring Vacua ; Supersymmetric Effective Theories
    ISSN: 11266708
    E-ISSN: 1029-8479
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  • 8
    Language: English
    In: Journal of High Energy Physics, June, 2014, Vol.2014(6), p.1(35)
    Description: Byline: Katrin Becker (1), Daniel Robbins (2), Edward Witten (3,4) Keywords: Superstrings and Heterotic Strings; M-Theory Abstract: In the approximation corresponding to the classical Einstein equations, which is valid at large radius, string theory compactification on a compact manifold M of G .sub.2 or Spin(7) holonomy gives a supersymmetric vacuum in three or two dimensions. Do [alpha] .sup. corrections to the Einstein equations disturb this statement? Explicitly analyzing the leading correction, we show that the metric of M can be adjusted to maintain supersymmetry. Beyond leading order, a general argument based on low energy effective field theory in spacetime implies that this is true exactly (not just to all finite orders in [alpha] .sup. ). A more elaborate field theory argument that includes the massive Kaluza-Klein modes matches the structure found in explicit calculations. In M-theory compactification on a manifold M of G .sub.2 or Spin(7) holonomy, similar results hold to all orders in the inverse radius of M -- but not exactly. The classical moduli space of G .sub.2 metrics on a manifold M is known to be locally a Lagrangian submanifold of H .sup.3(M, R ) a H .sup.4(M, R ). We show that this remains valid to all orders in the [alpha] .sup. or inverse radius expansion. Author Affiliation: (1) George P. and Cynthia W. Mitchell Institute for Fundamental Physics and Astronomy, Texas A& M University, College Station, TX, 77843-4242, U.S.A (2) Institute for Theoretical Physics, University of Amsterdam, Postbus 94485, 1090 GL, Amsterdam, The Netherlands (3) School of Natural Sciences, Institute for Advanced Study, Einstein Drive, Princeton, NJ, 08540, U.S.A (4) Department of Physics, University of Washington, Seattle, Washington, 98195, U.S.A Article History: Registration Date: 10/06/2014 Received Date: 15/04/2014 Accepted Date: 14/05/2014 Online Date: 10/06/2014 Article note: ArXiv ePrint: 1404.2460
    Keywords: Resveratrol -- Analysis
    ISSN: 1029-8479
    Source: Cengage Learning, Inc.
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  • 9
    Language: English
    In: Journal of High Energy Physics, 2011, Vol.2011(12), pp.1-24
    Description: We evaluate the string theory disc amplitude of one Ramond-Ramond field C ( p −3) and two Neveu-Schwarz B -fields in the presence of a single D p -brane in type II string theory. From this amplitude we extract the four-derivative (or equivalently order α ′2 ) part of the D p -brane action involving these fields. We show that the new couplings are invariant under R-R and NS-NS gauge transformations and compatible with linear T-duality.
    Keywords: Superstrings and Heterotic Strings ; D-branes ; Flux compactifications
    E-ISSN: 1029-8479
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  • 10
    Language: English
    In: Journal of High Energy Physics, 2012, Vol.2012(1), pp.1-46
    Description: We study in detail the procedure for obtaining couplings of D-branes to closed string fields by evaluating string theory disc amplitudes. We perform a careful construction of the relevant vertex operators and discuss the effects of inserting the boundary state which encodes the presence of the D-brane. We confront the issue of non-decoupling of BRSTexact states and prove that the problem is evaded for the computations we need, thus demonstrating that our amplitudes are automatically gauge-invariant and independent of the distribution of picture charge. Finally, we compute explicitly the two-point amplitudes of two NS-NS fields or one NS-NS and one R-R field on the disc, and we carefully compare all the lowest order terms with predictions from supergravity.
    Keywords: D-branes ; Flux compactifications ; BRST Symmetry
    E-ISSN: 1029-8479
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