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Berlin Brandenburg

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  • 1
    In: Nature Genetics, 2011, Vol.43(8), p.723
    Description: New work has identified networks of protein interactions at the transition zones of cilia. These discoveries provide insights into the molecular pathogenesis of ciliopathies and illustrate the power of linking proteomics technologies with human genetics to uncover critical disease pathways.
    Keywords: Proteomics ; Cilia ; Protein Interaction ; Human Genetics ; Miscellaneous;
    ISSN: 1061-4036
    E-ISSN: 15461718
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  • 2
    In: The New England Journal of Medicine, 2011, Vol.364(16), pp.1533-1543
    Description: A ciliopathy is a disease in which a hairlike cellular organelle called the cilium is dysfunctional. Most proteins altered in these single-gene disorders function at the level of the cilium–centrosome complex. This review considers the role of the cilium in disease. Diverse developmental and degenerative single-gene disorders such as polycystic kidney disease, nephronophthisis, retinitis pigmentosa, the Bardet–Biedl syndrome, the Joubert syndrome, and the Meckel syndrome may be categorized as ciliopathies — a recent concept that describes diseases characterized by dysfunction of a hairlike cellular organelle called the cilium. Most of the proteins that are altered in these single-gene disorders function at the level of the cilium–centrosome complex, which represents nature's universal system for cellular detection and management of external signals. Cilia are microtubule-based structures found on almost all vertebrate cells. They originate from a basal body, a modified centrosome, which is . . .
    Keywords: Medicine;
    ISSN: 0028-4793
    E-ISSN: 1533-4406
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  • 3
    Language: English
    In: Clinical chemistry, May 2012, Vol.58(5), pp.837-45
    Description: An imbalance in circulating factors that regulate blood vessel formation and health, referred to as angiogenic factors, plays a central role in the pathogenesis of preeclampsia. Several studies have demonstrated a strong association between altered circulating angiogenic factors and preeclampsia. These factors include circulating antiangiogenic proteins such as soluble fms-like tyrosine kinase 1 and soluble endoglin and proangiogenic protein such as placental growth factor. Abnormalities in these circulating angiogenic factors are not only present during clinical disease, but also antedate clinical signs and symptoms by several weeks. These alterations are particularly prominent in patients who present with preeclamptic signs and symptoms prematurely and/or in patients with severe preeclampsia. The availability of automated platforms for the rapid measurement of circulating angiogenic proteins in blood samples has now allowed researchers and clinicians to evaluate the utility of these assays in the diagnosis of the disease, in the stratification of patients in clinical trials, or in the monitoring of therapies. In this review we highlight the various studies that have been performed, with a focus on large validation studies. Measurement of circulating angiogenic proteins for the diagnosis and prediction of preeclampsia is still at an early stage but is rapidly evolving. Standardization across the various automated platforms and prospective studies that demonstrate clinical utility are needed.
    Keywords: Antigens, CD -- Analysis ; Pre-Eclampsia -- Diagnosis ; Pregnancy Proteins -- Analysis ; Receptors, Cell Surface -- Analysis ; Vascular Endothelial Growth Factor Receptor-1 -- Analysis
    ISSN: 00099147
    E-ISSN: 1530-8561
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  • 4
    In: Nature Reviews Nephrology, 2014
    ISSN: 1759-5061
    Source: Nature Publishing Group
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  • 5
    In: Circulation, 2012, Vol.126(3), pp.296-303
    Description: BACKGROUND—: Contrast medium–induced acute kidney injury is associated with substantial morbidity and mortality. The underlying mechanism has been attributed in part to ischemic kidney injury. The aim of this randomized, double-blind, sham-controlled trial was to assess the impact of remote ischemic preconditioning on contrast medium–induced acute kidney injury. METHODS AND RESULTS—: Patients with impaired renal function (serum creatinine 〉1.4 mg/dL or estimated glomerular filtration rate 〈60 mL · min · 1.73 m) undergoing elective coronary angiography were randomized in a 1:1 ratio to standard care with (n=50) or without ischemic preconditioning (n=50; intermittent arm ischemia through 4 cycles of 5-minute inflation and 5-minute deflation of a blood pressure cuff). Overall, both study groups were at high risk of developing contrast medium–induced acute kidney injury according to the Mehran risk score. The primary end point was the incidence of contrast medium–induced kidney injury, defined as an increase in serum creatinine ≥25% or ≥0.5 mg/dL above baseline at 48 hours after contrast medium exposure. Contrast medium–induced acute kidney injury occurred in 26 patients (26%), 20 (40%) in the control group and 6 (12%) in the remote ischemic preconditioning group (odds ratio, 0.21; 95% confidence interval, 0.07–0.57; P=0.002). No major adverse events were related to remote ischemic preconditioning. CONCLUSIONS—: Remote ischemic preconditioning before contrast medium use prevents contrast medium–induced acute kidney injury in high-risk patients. Our findings merit a larger trial to establish the effect of remote ischemic preconditioning on clinical outcomes. CLINICAL TRIAL REGISTRATION—: URL: http://www.germanctr.de. Unique identifier: U1111-1118-8098.
    Keywords: Medicine ; Anatomy & Physiology;
    ISSN: 0009-7322
    E-ISSN: 15244539
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  • 6
    In: Nature Reviews Nephrology, 2016
    Description: A new study reports that a single blood test can be used to rule out the development of pre-eclampsia in women in whom the syndrome is suspected. Early interventions for pre-eclampsia are not yet available, but this finding is likely to change the approach to diagnosis of hypertensive disorders in pregnancy.
    Keywords: Pre-Eclampsia -- Diagnosis ; Pregnancy Proteins -- Blood ; Vascular Endothelial Growth Factor Receptor-1 -- Blood;
    ISSN: 1759-5061
    E-ISSN: 1759507X
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  • 7
    Language: English
    In: Nature Reviews Nephrology, March, 2015, Vol.11(3), p.129(2)
    Description: New research suggests that rigorous blood pressure control is beneficial in early autosomal dominant polycystic kidney disease (ADPKD). Although a positive effect on the rate of decline of estimated glomerular filtration rate remains to be demonstrated, this study is likely to change current treatment strategies for young patients with ADPKD. Benzing, T. Nat. Rev. Nephrol. 11, 129-131 (2015); published online 16 December 2014; doi: 10.1038/nrneph.2014.241
    Keywords: Polycystic Kidney Disease -- Care And Treatment ; Blood Pressure Regulation -- Health Aspects
    ISSN: 1759-5061
    E-ISSN: 1759507X
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  • 8
    Language: English
    In: Nature Reviews Nephrology, April, 2016, Vol.12(4), p.200(2)
    Keywords: Preeclampsia -- Diagnosis ; Preeclampsia -- Research ; Blood Tests -- Research ; Blood Tests -- Methods
    ISSN: 1759-5061
    E-ISSN: 1759507X
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  • 9
    Language: English
    In: Kidney International, May 2015, Vol.87(5), pp.885-893
    Description: Glomerular kidney diseases are a major cause of end-stage renal disease (ESRD). Thus, it comes as wonderful news that glomerular research is advancing at a remarkable pace. Researchers from around the world met at the 10th International Podocyte Conference in Freiburg, Germany, to discuss the latest developments and findings in this innovative field of kidney research. The meeting highlighted the tremendous progress in our understanding of podocyte-related disorders and promised a rapid transfer of this knowledge into novel treatment options for proteinuric kidney diseases.
    Keywords: Diabetic Nephropathy ; Fsgs ; Glomerular Biology ; Membranous Nephropathy ; Podocyte ; Proteinuria ; Medicine
    ISSN: 0085-2538
    E-ISSN: 1523-1755
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  • 10
    Language: English
    In: The Journal of biological chemistry, 27 May 2016, Vol.291(22), pp.11596-607
    Description: Transcriptional co-activator with PDZ-binding motif (TAZ) and Yes-associated protein (YAP) are critical transcriptional co-activators downstream of the Hippo pathway involved in the regulation of organ size, tissue regeneration, proliferation, and apoptosis. Recent studies suggested common and distinct functions of TAZ and YAP and their diverse impact under several pathological conditions. Here we report differential regulation of TAZ and YAP in response to oxidative stress. H2O2 exposure leads to increased stability and activation of TAZ but not of YAP. H2O2 induces reversible S-glutathionylation at conserved cysteine residues within TAZ. We further demonstrate that TAZ S-glutathionylation is critical for reactive oxygen species (ROS)-mediated, TAZ-dependent TEA domain transcription factor (TEAD) trans-activation. Lysophosphatidic acid, a physiological activator of YAP and TAZ, induces ROS elevation and, subsequently, TAZ S-glutathionylation, which promotes TAZ-mediated target gene expression. TAZ expression is essential for renal homeostasis in mice, and we identify basal TAZ S-glutathionylation in murine kidney lysates, which is elevated during ischemia/reperfusion injury in vivo This induced nuclear localization of TAZ and increased expression of connective tissue growth factor. These results describe a novel mechanism by which ROS sustains total cellular levels of TAZ. This preferential regulation suggests TAZ to be a redox sensor of the Hippo pathway.
    Keywords: Hippo Pathway ; S-Glutathionylation ; Yes-Associated Protein (Yap) ; Connective Tissue Growth Factor (Ctgf) ; Oxidative Stress ; Reactive Oxygen Species (Ros) ; Transcriptional Co-Activator With Pdz-Binding Motif (Taz) ; Cysteine -- Metabolism ; Glutathione -- Metabolism ; Intracellular Signaling Peptides and Proteins -- Metabolism ; Nuclear Proteins -- Metabolism ; Protein-Serine-Threonine Kinases -- Metabolism ; Reperfusion Injury -- Metabolism ; Trans-Activators -- Metabolism ; Transcription Factors -- Metabolism
    E-ISSN: 1083-351X
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