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  • 1
    UID:
    almahu_9948126255702882
    Format: XX, 440 p. 76 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030184087
    Series Statement: Energy Balance and Cancer, 15
    Content: This volume familiarizes readers with what has now become a very specific research endeavor, Geospatial Factors Impacting Breast Cancer. Cancer occurs in specific places and spaces, each of which have identifiable geographic coordinates, characterized by unique natural, built and social characteristics. These factors contribute significantly to cancer across the spectrum, from etiology through diagnosis, treatment, and outcomes. The book provides important insights into this relatively new and rapidly developing field as a wide-ranging introduction to problems in cancer prevention and control for geographers, demographers and other researchers with a geospatial perspective. Experts share important information for all oncologists, endocrinologists, and behavioral modification professionals to better understand their patients in the context of their environment. The book also outlines important considerations for physicians, scientists, public health professionals and disparity investigators planning clinical trials, community interventions, and community planning.
    Note: Part One – Overview and Spatial Methods -- Chapter 1: Connecting Population, Health and Place (With Geospatial Tools and Data) -- Chapter 2: Analyzing cancer and breast cancer in space and time -- Chapter 3: Creating Maps and Mapping Systems for Cancer Control and Prevention -- Chapter 4: Physical Activity and Exposure in Breast Cancer Survivors Using GPS, GIS, and Accelerometry -- Chapter 5: Towards Systematic Methods in an Era of Big Data: Neighborhood Wide Association Studies -- Chapter 6: Geospatial Approaches to Environmental Determinants of Breast Cancer in the California Teachers Study -- Chapter 7: Systematic Review of Geospatial Approaches to Breast Cancer Epidemiology -- Part Two – Environment and Context -- Chapter 8: Studying the Influence of the Neighborhood Obesogenic Environment on Breast Cancer in Epidemiological Cohorts: the Multiethnic Cohort -- Chapter 9: Spatial analyses of Environmental Exposures and Breast Cancer: Natural Vegetation, Ambient Air Pollution and Outdoor Light at Night as Examples -- Chapter 10: Neighborhoods and Breast Cancer Survival: The Case for an Archetype Approach -- Chapter 11: Environmental Modification of Adult Weight Loss, Physical Activity, and Diet Intervention Effects -- Part Three – Screening, Diagnosis and Beyond -- Chapter 12: Geographic Influences on Screening Mammography -- Chapter 13: Spatial and Contextual Analyses of Stage at Diagnosis -- Chapter 14: Geographic Variation in Medical Neighborhoods for Breast Cancer Care: Diagnosis and Beyond -- Part Four – Cross-cutting Topics -- Chapter 15: Persistent racial disparities in breast cancer mortality between Black and White women: what SR -- Chapter 16: Rural-Urban Disparities in Breast Cancer: Six Suppositions and Future Directions -- Chapter 17: Microenvironmental Influences on Team Performance in Cancer Care -- Chapter 18: Opportunities and Challenges in Geospatial Approaches to Breast Cancer Prevention and Control -- Index.
    In: Springer eBooks
    Additional Edition: Printed edition: ISBN 9783030184070
    Additional Edition: Printed edition: ISBN 9783030184094
    Additional Edition: Printed edition: ISBN 9783030184100
    Language: English
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  • 2
    Online Resource
    Online Resource
    Boston, MA : Springer US
    UID:
    gbv_1651396884
    Format: Online-Ressource (XII, 184 p. 15 illus., 10 illus. in color, online resource)
    ISBN: 9781461423676
    Series Statement: Energy Balance and Cancer 4
    Content: Nathan A. Berger
    Content: The gastrointestinal track provides one of the distinct systems where multiple malignancies, including adenocarcinoma of the pancreas, esophagus and colon are each associated with obesity. This unique association is covered in this volume of Energy Balance and Cancer from the epidemiologic, biologic and potential etiologic viewpoint. The focus on possible dietary contribution as well as the role of exercise in prevention and therapy is presented in both animal model and patient based studies. Special focus is provided also on the role of genetic mutations and inflammatory pathways as drivers of these obesity related gastrointestinal malignancies. Overall, this volume on Energy Balance and Gastrointestinal Malignancies should be valuable to Epidemiologists, Gastroenterologists and Oncologists, as well as to students and researchers from multiple disciplines interested in understanding and disrupting the association between obesity and cancer.
    Note: Description based upon print version of record , Energy Balance and Gastrointestinal Cancer; Preface; References; Contents; Contributors; Chapter 1: Obesity and Gastrointestinal Cancers: Epidemiology; 1 Obesity: Definitions; 2 Obesity Rates; 3 Gastrointestinal Cancers: Incidence Rates; 4 Gastrointestinal Cancers: Mortality Rates; 5 Obesity and Metabolic Syndrome; 6 Obesity and Gastrointestinal Cancers: Epidemiological Evidence; 6.1 Obesity and Colorectal Cancers; 6.2 Obesity and Esophageal Cancer; 6.3 Obesity and Gastric Cancer; 6.4 Obesity and Gallbladder Cancer; 6.5 Obesity and Liver Cancer; 6.6 Obesity and Pancreatic Cancer , 7 Obesity and Gastrointestinal Cancer Mortality: Epidemiological Evidence8 Metabolic Syndrome and Gastrointestinal Cancers: Epidemiological Evidence; 9 Conclusions; References; Chapter 2: Genetics of Colon Cancer Susceptibility; 1 Familial Adenomatous Polyposis; 2 Hereditary Nonpolyposis Colon Cancer/Lynch Syndrome; 3 MUTYH-Associated Polyposis; 4 Familial Colorectal Cancer Type X; 5 Hamartomatous Polyposis and Other Rare Syndromes; 6 Genome-Wide Association Studies and Low-Penetrance Mutations; 7 CRC Susceptibility Genes and Energy Balance; References , Chapter 3: Dietary Modulation of Colon Cancer: Effects on Intermediary Metabolism, Mucosal Cell Differentiation, and Inflammation1 Introduction; 2 Links of Intestinal Tumor Models to Inflammation; 3 The Importance of Nutrients, in Particular Vitamin D and Calcium, in Human Colon Cancer; 4 Insight on Nutrition and Intestinal Cancer from Mouse Models; 5 Cellular and Molecular Effects of Diet and Inflammation on Intestinal Tumorigenesis; 6 Concluding Remarks; References; Chapter 4: The Apc Min/+ Mouse Model to Study the Effects of Exercise on Gastrointestinal Malignancy; References , Chapter 5: Obesity and the Pathogenesis of Barrett's Esophagus1 Introduction; 2 Definition: Barrett's Esophagus; 3 GERD and BE; 4 The Cancer Progression Model of Esophageal Adenocarcinoma; 5 Prevalence of BE and EAC; 6 Obesity Is the Key Modifiable Risk Factor at Each Stage of Neoplastic Progression; 6.1 GERD, EAC, and Obesity; 7 BE and Obesity; 7.1 BMI and BE Meta-analysis; 7.2 Central Obesity and BE; 8 Central Obesity and GERD as Comodulators of BE Pathogenesis; 8.1 Evidence for Leptin; 8.2 Evidence for Adiponectin; 8.3 Evidence for Free Fatty Acids , 9 Future Directions: Physical Activity as a Modifiable Risk FactorReferences; Chapter 6: Obesity and Pancreatic Cancer; 1 Pancreatic Cancer; 2 Obesity and Risk of Pancreatic Cancer; 2.1 Body Mass Index; 2.2 Central Adiposity; 2.3 Physical Activity; 3 Obesity and Age of Onset and Survival of Pancreatic Cancer; 3.1 Age of Onset; 3.2 Survival; 3.3 Mortality; 4 Mechanism of Obesity-Related Pancreatic Cancer; 4.1 Adipokines; 4.2 Insulin Resistance; 4.3 Inflammation; 4.4 Genetic Susceptibility; 5 Conclusion; References; Chapter 7: Obesity, Insulin Resistance Pathway Factors, and Colon Cancer , 1 Introduction
    Additional Edition: ISBN 9781461423669
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-146-142-366-9
    Language: English
    Subjects: Medicine
    RVK:
    URL: Cover
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  • 3
    Online Resource
    Online Resource
    New York, NY : Springer
    UID:
    gbv_1652404953
    Format: Online-Ressource (XIII, 433 p. 37 illus., 28 illus. in color, digital)
    ISBN: 9781461468196
    Series Statement: Energy Balance and Cancer 7
    Content: In addition to their metabolic and endocrinologic effects, obesity and adipose tissue have now been shown to be associated with chronic low grade inflammation resulting in cellular and humoral factors of which the latter may act by endocrine, paracrine and autocrine mechanisms. These inflammatory mediators have increasingly been suggested as contributing to the obesity link to carcinogenesis and cancer promotion. Obesity, Inflammation and Cancer focuses on recent developments and cutting edge research pointing to inflammation and inflammatory factors as key mediators of this linkage. It also describes possible strategies for targeting inflammation as an approach to cancer prevention and control. Students, researchers and clinicians, especially those interested in the relation of obesity to cancer and the role of inflammation and its impact on cancer, will find this volume particularly useful. It provides important insight on the role of inflammation in cancer etiology and progression and serve as a platform for developing future research in this area
    Note: Includes bibliographical references and index , Preface: What's Old Is New Again and Now It's Red Hot; Contents; Contributors; Chapter 1: Obesity, Inflammation, and Insulin Resistance; 1.1 Introduction; 1.2 Insulin Signaling; 1.3 Immune Cells; 1.3.1 Macrophages; 1.3.2 Neutrophils; 1.3.3 CD4 + T Cells: T-Helper and T-Regulatory Cell Subsets; 1.3.4 CD8 + T Cells; 1.3.5 B Cells; 1.3.6 Natural Killer T Cells; 1.3.7 Eosinophils; 1.3.8 Mast Cells; 1.4 Signaling Pathways Linking Inflammation and Insulin Resistance; 1.4.1 Cytokine Signaling; 1.4.2 Lipid Signaling; 1.4.3 ER Stress; 1.4.4 Hypoxia; 1.5 Anti-inflammatory Therapies , 1.6 Links with Cancer1.7 Conclusions; References; Chapter 2: Inflammasomes and Obesity; 2.1 Inflammasomes Are Key Mediators of the Innate Immune System; 2.2 The NLRP3 Inflammasome is a Major Mediator of Human Disease; 2.2.1 NLRP3 Inflammasome-Priming Signals; 2.2.2 The Assembly of the NLRP3 Inflammasome; 2.3 The Diverse Regulation of NLRP3 Inflammasome Activation; 2.3.1 Reactive Oxygen Species; 2.3.2 Cytoplasmic Potassium; 2.3.3 Phagocytosis and Lysosomal Damage; 2.3.4 The NLRP3 Inflammasome is Negatively Regulated by IFNγ and T Cell Responses; 2.4 NLRP3 Inflammasome Is a Metabolic Regulator , 2.4.1 Fatty Acids2.4.2 Hyperglycemia; 2.4.3 Uric Acid and MSU Crystals; 2.4.4 Cholesterol; 2.4.5 Amyloid; 2.5 Obesity and the NLRP3 Inflammasome; 2.5.1 Chronic Inflammation in Adipose Tissue; 2.5.2 NLRP3 Inflammasome Expression and Activity in Obese Mice; 2.5.3 NLRP3 Inflammasome Expression and Activity in Obese Patients; 2.5.4 Mechanisms of NLRP3 Inflammasome Activation in Adipose Tissue; 2.6 The NLRP3 Inflammasome in Metabolic Diseases Associated with Obesity; 2.6.1 Type 1 and Type 2 Diabetes; 2.6.2 Metabolic Liver Disease; 2.6.3 Atherosclerosis; 2.6.4 Gout; 2.6.5 Alzheimer's Disease , 2.7 Cancer, Obesity and Inflammation2.7.1 Cell Death and Inflammasome Activity; 2.7.2 The Inflammasomes and Carcinogenesis; 2.7.3 Inflammasome-Dependent Anticancer Responses; 2.8 Pharmaceutical Interventions Targeting the Inflammasome; 2.8.1 Therapeutics Targeting IL-1β Activity; 2.8.2 Therapeutic Approaches Acting on the Inflammasome or Caspase-1; 2.8.3 Other Therapeutic Targets to Attenuate Inflammasome Activity; 2.9 Summary; References; Chapter 3: Uncoupling Obesity from Cancer: Bromodomain Co-regulators That Control Inflammatory Networks; 3.1 The Problem of Obesity-Associated Cancer , 3.2 Molecular Features of Insulin-Resistant Obesity3.3 Insulin-Resistant Obesity Is Also an Inflammatory Disease; 3.4 Insight from Unexpected Results; 3.5 Other Links Between Obesity, Inflammation, and Social Determinants; 3.6 Interactions Among Biological and Social Factors; References; Chapter 4: Adipose Tissue Macrophages in Obesity, Inflammation, and Cancer; 4.1 Introduction; 4.2 Adipose Tissue Macrophages as Inflammatory Engines in Obesity; 4.3 Adipose Tissue Macrophage Diversity; 4.3.1 Macrophage Activation States; 4.3.2 The M1/M2 Paradigm in Obesity , 4.3.3 The Nature of the Phenotypic Shift from M2-Like to M1-Like ATMs in Obesity
    Additional Edition: ISBN 9781461468189
    Additional Edition: Erscheint auch als Druck-Ausgabe Obesity, inflammation and cancer New York, NY : Springer, 2013 ISBN 9781461468189
    Language: English
    Subjects: Medicine
    RVK:
    Keywords: Fettsucht ; Entzündung ; Carcinogenese
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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  • 4
    Online Resource
    Online Resource
    New York, NY : Springer New York
    UID:
    gbv_1653176997
    Format: Online-Ressource (XIII, 239 p. 30 illus., 19 illus. in color, online resource)
    ISBN: 9781461495277
    Series Statement: Energy Balance and Cancer 8
    Content: This volume on the Impact of Sleep and Sleep Disturbances on Obesity and Cancer continues the transdisciplinary approach of this series with chapters authored by the leading experts in this field, focused on the normal regulation of the restorative sleep associated processes across the lifespan, the major mechanisms of sleep and circadian rhythm disturbances and the behavioral, physiologic, biochemical and molecular consequences of sleep disturbances. These areas, in turn, are discussed in relationship to their effects on cancer incidence and progression. Students and research scientists involved in all aspects of energy balance and cancer research and patient care should find this volume useful to better understand the causes, contributions and consequences of sleep and circadian rhythm disturbances and their relation to cancer. The volume outlines many exciting areas where research is needed. In addition to its value for researchers, it should be useful to all physicians and health care personnel who care for cancer patients and cancer survivors to better understand the importance of sleep, consequences of sleep disturbances and benefits of their correction
    Note: Description based upon print version of record , PrefaceSleep Across the Lifespan -- Effects of Sleep Deficiency on Hormones, Cytokines, and Metabolism -- Sleep Disorders and Melatonin -- Biomedical Effects of Circadian Rhythm Disturbances -- Intermittent Hypoxia: Mechanistic Pathways Influencing Cancer -- Association of Sleep Apnea and Cancer: From Animal Studies to Human Epidemiological Data -- Shift Work, Obesity, and Cancer -- Sleep Disorders and Cancer Risk -- Contribution of Sleep Disturbance to Cancer Fatigue -- Sleep Disturbances in Cancer Survivors -- Sleep-focused interventions: Investigating the effects of sleep restriction on energy balance -- Index.
    Additional Edition: ISBN 9781461495260
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-146-149-526-0
    Language: English
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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  • 5
    Online Resource
    Online Resource
    Cham :Springer International Publishing,
    UID:
    edoccha_BV044662223
    Format: 1 Online-Ressource (XII, 187 p. 11 illus., 10 illus. in color).
    ISBN: 978-3-319-64940-5
    Series Statement: Energy Balance and Cancer volume 14
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-319-64939-9
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 6
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    UID:
    almahu_9947420851502882
    Format: XII, 187 p. 11 illus., 10 illus. in color. , online resource.
    ISBN: 9783319649405
    Series Statement: Energy Balance and Cancer, 14
    Content: This volume provides a comprehensive treatise on the latest studies linking prostate cancer with energy balance, which together constitute a major challenge and opportunity for research scientists and clinicians especially those dealing with the expanding population of older men confronted with obesity and associated comorbidities. This volume should be a valuable resource to physicians, oncologists, urologists, endocrinologists, nurses, nutritionists, dieticians, and exercise therapists dealing with men with energy balance issues and/or questions regarding the linkage between energy balance and cancer. Moreover, this volume should serve as an important resource for cancer researchers especially for scientists studying lifestyle modification and prevention strategies to better understand and disrupt the linkage between obesity and cancer.
    Note: Chapter1. Epidemiology, energy balance and prostate cancer incidence and mortality -- Chapter2. Racial/Ethnic Differences in the Association between Energy Balance and Prostate Cancer -- Chapter3. Consequence of Energy Imbalance in Prostate Cancer and Comorbidities -- Chapter4. Adipokines and Prostate Cancer -- Chapter5. Cross-sectional epidemiology and intervention studies of mediators of the energy imbalance-prostate cancer association -- Chapter6. Impact of Metabolic Factors on Screening, Early Detection, and Management of Prostate Cancer -- Chapter7. Androgen Deprivation Therapy for Prostate Cancer: Effects on Body Composition and Metabolic Health -- Chapter8. The Integration of Exercise and Dietary Lifestyle Interventions into Prostate Cancer Care -- Chapter9. Energy Balance-Based Strategies to Reduce Consequences of Prostate Cancer:  How to Communicate with Men.
    In: Springer eBooks
    Additional Edition: Printed edition: ISBN 9783319649399
    Language: English
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  • 7
    Online Resource
    Online Resource
    Cham :Springer International Publishing,
    UID:
    edocfu_BV044662223
    Format: 1 Online-Ressource (XII, 187 p. 11 illus., 10 illus. in color).
    ISBN: 978-3-319-64940-5
    Series Statement: Energy Balance and Cancer volume 14
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-319-64939-9
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 8
    Online Resource
    Online Resource
    Cham :Springer International Publishing,
    UID:
    edocfu_BV044662222
    Format: 1 Online-Ressource (XIII, 312 p. 17 illus., 15 illus. in color).
    ISBN: 978-3-319-63483-8
    Series Statement: Energy Balance and Cancer volume 13
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-319-63482-1
    Language: English
    Subjects: Medicine
    RVK:
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 9
    UID:
    almahu_9947420846502882
    Format: XIII, 312 p. 17 illus., 15 illus. in color. , online resource.
    ISBN: 9783319634838
    Series Statement: Energy Balance and Cancer, 13
    Content: Gynecologic malignancies, especially endometrial and ovarian cancers are among the most important and most severely affected by obesity. This volume of Energy Balance and Cancer, written by the world’s leading experts in this field, is arranged to provide a transdisciplinary assessment of the pertinent issues, results of relevant research on mechanisms, and control, strategies for dealing with affected patients and improving outcomes and future research needs. The volume comprehensively covers the epidemiology linking obesity to endometrial and ovarian cancer as well as the public awareness of this critical problem. Subsequent chapters explain biologic aspects of linkages between energy balance and gynecologic malignancies. The volume further outlines strategies to disrupt the linkage between obesity and gynecologic malignancies and concludes with a series of chapters focused on management strategies for obese patients with gynecologic malignancies.  This volume provides a valuable resource for all physicians, scientists and other transdisciplinary investigators and practitioners interested and involved in energy balance and cancer. It should be a particularly useful guide to optimize outcomes for all practitioners dealing with patients with gynecologic malignancies challenged by energy balance issues. Moreover, it should serve as a useful guide to students and investigators interested in conducting further research on defining and disrupting the important linkage between energy balance and gynecologic malignancies.
    Note: 1. Epidemiologic Evidence for the Obesity-Endometrial Cancer Relationship -- 2. Epidemiologic Relationship Between Obesity and Ovarian Cancer -- 3. Public Knowledge of Obesity and Gynecologic Cancer Risk -- 4. Role of Estrogen and Progesterone in Obesity Associated Gynecologic Cancers -- 5. Obesity and Endometrial Cancer Precursors -- 6. Obesity, Adipokines, and Gynecologic Cancer -- 7. Adipose Derived Stromal Cells in Gynecologic Cancers -- 8. Obesity and Endometrial Cancer:  Mouse Models for Preclinical Prevention Studies -- 9. Lifestyle Interventions to Reduce the Risk of Obesity-Associated Gynecologic Malignancies: A Focus on Endometrial Cancer -- 10. Hormonal and Metabolic Strategies to Overcome Insulin Resistance and Prevent Endometrial Cancer -- 11. Management of Endometrial Cancer Precursors in Obese Women -- 12. Exercise and Lifestyle Interventions in Gynecologic Cancer Survivors -- 13. Physical Activity as a Risk Factor for Ovarian Cancer -- 14. Impact of Obesity on Surgical Approaches to Gynecologic Malignancies -- 15. Obesity, Fertility Preservation and Gynecologic Cancers -- 16. Metformin as Adjuvant Therapy in Ovarian and Endometrial Cancers.
    In: Springer eBooks
    Additional Edition: Printed edition: ISBN 9783319634821
    Language: English
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  • 10
    Online Resource
    Online Resource
    Cham :Springer International Publishing,
    UID:
    edoccha_BV044662222
    Format: 1 Online-Ressource (XIII, 312 p. 17 illus., 15 illus. in color).
    ISBN: 978-3-319-63483-8
    Series Statement: Energy Balance and Cancer volume 13
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-319-63482-1
    Language: English
    Subjects: Medicine
    RVK:
    URL: Volltext  (URL des Erstveröffentlichers)
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