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  • 1
    Online Resource
    Online Resource
    Marrow protection : transduction of hematopoietic cells with drug resistance genes (1999)
    Basel : Karger
    Details
    UID:
    b3kat_BV036069230
    Format: 1 Online-Ressource (VII, 184 Seiten) , Illustrationen
    ISBN: 9783318003970
    Series Statement: Progress in experimental tumor research Vol. 36
    Content: Authored by experts in the field, this volume provides a comprehensive review of the problems and opportunities in gene therapy focusing on the use of various drug resistance genes to provide protection of hematopoietic cells against drug toxicity.General topics include basic principles of gene transfer, optimizing conditions for gene transfer in hematopoietic cells, and gene transfer in the nonmyeloablated host. Specific chapters describe constructions and preclinical studies of specific genes that impart resistance to anticancer drugs when expressed in hematopoietic cells including MDR-1, mutated forms of human methylguanine-DNA-methyltranferase, mutant forms of dihydrofolate reductase and thymidylate synthase, dihydropyrimidine dehydrogenase and cytidine deaminase. For successful transfer of drug resistance genes, the possibility that they may be used as selectable markers and that marrow ablation may not be required are important considerations.This book is especially timely, as clinical trials with these drug resistance genes are expected to increase markedly in the next few years. It should appeal to all interested in stem cell biology and gene therapy, as well as clinicians who look forward to using this technology in their practice
    Note: important reading for anyone interested in gene therapy
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-8055-6828-9
    Language: English
    Subjects: Medicine
    RVK:
    XH 3239
    Keywords: Blutstammzelle ; Transduktion ; Arzneimittelresistenz ; Resistenzgen ; Cytostatikum ; Immunsuppression ; Granulozytopenie ; Blutstammzelle ; Gentransfer ; Arzneimittelresistenz ; Aufsatzsammlung
    DOI: 10.1159/isbn.978-3-318-00397-0
    URL: Volltext
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    Online Access
    Open Access Request
    HU Berlin
    EUV Frankfurt
    TH Brandenburg
    TH Wildau
    Charité
    TU Berlin
  • 2
    Online Resource
    Online Resource
    Marrow protection : transduction of hematopoietic cells with drug resistance renes ; important reading for anyone interested in gene therapy (1999)
    Basel : Karger
    Details
    UID:
    gbv_1672336104
    Format: VIII + 184 S
    Edition: Online-Ausg.] Online-Ressource Karger eBooks Collection 1997-2009
    Series Statement: Progress in experimental tumor research 36
    Content: Authored by experts in the field, this volume provides a comprehensive review of the problems and opportunities in gene therapy focusing on the use of various drug resistance genes to provide protection of hematopoietic cells against drug toxicity.General topics include basic principles of gene transfer, optimizing conditions for gene transfer in hematopoietic cells, and gene transfer in the nonmyeloablated host. Specific chapters describe constructions and preclinical studies of specific genes that impart resistance to anticancer drugs when expressed in hematopoietic cells including MDR-1, mutated forms of human methylguanine-DNA-methyltranferase, mutant forms of dihydrofolate reductase and thymidylate synthase, dihydropyrimidine dehydrogenase and cytidine deaminase. For successful transfer of drug resistance genes, the possibility that they may be used as selectable markers and that marrow ablation may not be required are important considerations.This book is especially timely, as clinical trials with these drug resistance genes are expected to increase markedly in the next few years. It should appeal to all interested in stem cell biology and gene therapy, as well as clinicians who look forward to using this technology in their practice
    Additional Edition: ISBN 9783318003970
    Language: English
    URL: lizenzpflichtig
    URL: Volltext
    URL: Volltext  (Deutschlandweit zugänglich)
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    Stabi Berlin
    UB Potsdam
    MPI Bildungsforschung
  • 3
    Book
    Book
    Folate antagonists as chemotherapeutic agents : [result of a Conference Entitled Folate Antagonists as Chemotherapeutic Agents, held by the New York Academy of Sciences on January 11 - 13, 1971] (1971)
    New York, NY : New York Academy of Sciences
    Details
    UID:
    gbv_237733005
    Format: 519 S. , Ill., graph. Darst.
    Series Statement: Annals of the New York Academy of Sciences 186
    Note: Literaturangaben
    Language: English
    Keywords: Konferenzschrift
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  • 4
    Online Resource
    Online Resource
    Clinical Ethics for Consultation Practice (2022)
    Cham : Springer International Publishing | Cham : Springer
    Details
    UID:
    b3kat_BV047636323
    Format: 1 Online-Ressource (XXVI, 162 p)
    Edition: 1st ed. 2022
    ISBN: 9783030901820
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-90181-3
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-90183-7
    Language: English
    DOI: 10.1007/978-3-030-90182-0
    URL: Volltext  (URL des Erstveröffentlichers)
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    Online Resource
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    Charité
  • 5
    Book
    Book
    Encyclopedia of cancer; 3: R - Z, glossary index (1996)
    San Diego [u.a.] : Acad. Press
    Show associated volumes
    Details
    UID:
    b3kat_BV011096777
    Format: XXXVIII S., S. 1349 - 2134 , Ill., graph. Darst.
    ISBN: 0120932334
    In: 3
    Language: English
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  • 6
    Book
    Book
    Encyclopedia of cancer; 2: G - Q (1996)
    San Diego [u.a.] : Acad. Press
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    Details
    UID:
    b3kat_BV011096762
    Format: XXXVIII, S. 681 - 1348 , Ill., graph. Darst.
    ISBN: 0120932326
    In: 2
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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    BTU Cottbus get availability status
  • 7
    Book
    Book
    Encyclopedia of cancer; 1: A - F (1996)
    San Diego [u.a.] : Acad. Press
    Show associated volumes
    Details
    UID:
    b3kat_BV011096747
    Format: XXXVIII, 679 S. , Ill., graph. Darst.
    ISBN: 0120932318
    In: 1
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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    BTU Cottbus get availability status
  • 8
    Book
    Book
    Folate antagonists as chemotherapeutic agents : this series of papers is the result of a conference entitled ..., held by the New York Academy of Sciences on January 11 - 13, 1971 (1971)
    New York
    Details
    UID:
    b3kat_BV002116174
    Format: 519 S.
    Series Statement: New York Academy of Sciences: Annals of the ... 186
    Language: Undetermined
    Keywords: Konferenzschrift
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  • 9
    Book
    Book
    Marrow protection : transduction of hematopoietic cells with drug resistance genes ; 21 tables (1999)
    Basel [u.a.] : Karger
    Details
    UID:
    gbv_268216185
    Format: VII, 184 S , Ill., graph. Darst , 25 cm
    ISBN: 3805568282
    Series Statement: Progress in experimental tumor research 36
    Note: Literaturangaben
    Language: English
    Subjects: Medicine
    RVK:
    XH 3239
    Keywords: Blutstammzelle ; Transduktion ; Arzneimittelresistenz ; Resistenzgen ; Aufsatzsammlung
    URL: Inhaltsverzeichnis
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    Stabi Berlin get availability status
  • 10
    Online Resource
    Online Resource
    Methotrexate (2000)
    Basel : Birkhäuser Basel
    Details
    UID:
    gbv_749251069
    Format: Online-Ressource (IX, 139 p) , digital
    Edition: Springer eBook Collection. Biomedical and Life Sciences
    ISBN: 9783034884525
    Series Statement: Milestones in Drug Therapy
    Content: This book provides multidisciplinary reviews of the mechanism of action and uses of methotrexate in the treatment of cancer, psoriasis, gynecologic and inflammatory diseases. The intended audience is composed of clinicians involved in the care of patients suffering from oncologic, gynecologic, rheumatic diseases as well as scientists involved in research into the pathogenesis and treatment of these diseases. This book is unique in that it provides a single, state-of-the-art source for information regarding the mechanism and use of methotrexate in many different areas of medicine
    Additional Edition: ISBN 9783034895736
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9783764359591
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9783034895736
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9783034884532
    Language: English
    DOI: 10.1007/978-3-0348-8452-5
    URL: Volltext  (lizenzpflichtig)
    URL: lizenzpflichtig
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    Online Resource
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    UB Potsdam
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