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Berlin Brandenburg

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  • 1
    Language: English
    In: Brain Research, 2001, Vol.891(1), pp.281-284
    Description: Urethane anaesthesia strongly reduced the peripheral edema (31 plus or minus 5 and 96 plus or minus 8% reduction of carrageenan-enhanced paw and ankle diameters, respectively; P〈0.001 for both) and the spinal c-Fos protein expression (71 plus or minus 4% reduction of the number of c-Fos protein-labeled nuclei; P〈0.001), 3 h after intraplantar injection of carrageenan in rats. In urethane anaesthetised rats, i.v. injection of racemic-flurbiprofen (0.3, 3 and 9 mg/kg) has weaker effects on carrageenan-evoked spinal c-Fos protein expression and peripheral edema than those previously described in the same inflammatory nociceptive model in awake rats.
    Keywords: C-Fos ; Flurbiprofen ; Carrageenan ; Urethane Anaesthesia ; Spinal Dorsal Horn ; Anatomy & Physiology
    ISSN: 0006-8993
    E-ISSN: 1872-6240
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  • 2
    Article
    Article
    Language: English
    In: Pain, 1999, Vol.82, pp.S3-S4
    Keywords: Medicine
    ISSN: 0304-3959
    E-ISSN: 1872-6623
    Source: ScienceDirect Journals (Elsevier)
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  • 3
    Language: French
    In: Drugs, 1997, Vol.53, pp.63-64
    Keywords: Medicine & Public Health ; Pharmacotherapy ; Pharmacology/Toxicology ; Internal Medicine ; Pharmacy, Therapeutics, & Pharmacology;
    ISSN: 0012-6667
    E-ISSN: 1179-1950
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  • 4
    Language: English
    In: Drugs, 1997, Vol.53, pp.65-66
    Keywords: Medicine & Public Health ; Pharmacotherapy ; Pharmacology/Toxicology ; Internal Medicine ; Pharmacy, Therapeutics, & Pharmacology;
    ISSN: 0012-6667
    E-ISSN: 1179-1950
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  • 5
    In: American Journal of Epidemiology, 2011, Vol. 174(3), pp.326-335
    Description: The role of influenzalike illnesses and influenza vaccination in the development of Guillain-Barré syndrome (GBS), particularly the role of A/H1N1 epidemics and A/H1N1 vaccination, is debated. Data on all incident GBS cases meeting the Brighton Collaboration criteria that were diagnosed at 25 neurology centers in France were prospectively collected between March 2007 and June 2010, covering 3 influenzavirus seasons, including the 2009–2010 A/H1N1 outbreak. A total of 457 general practitioners provided a registry of patients from which 1,080 controls were matched by age, gender, index date (calendar month), and region to 145 cases. Causal relations were assessed by multivariate case-control analysis with adjustment for risk factors (personal and family history of autoimmune disorders, among others), while matching on age, gender, and calendar time. Influenza (seasonal or A/H1N1) or influenzalike symptoms in the 2 months preceding the index date was associated with GBS, with a matched odds ratio of 2.3 (95% confidence interval (CI): 0.7, 8.2). The difference in the rates of GBS occurring between influenza virus circulation periods and noncirculation periods was highly statistically significant ( P = 0.004). Adjusted odds ratios for GBS occurrence within 6 weeks after seasonal and A/H1N1 vaccination were 1.3 (95% CI: 0.4, 4.1) and 0.9 (95% CI: 0.1, 7.6), respectively. Study results confirm that influenza virus is a likely risk factor for GBS. Conversely, no new concerns have arisen regarding influenza vaccination.
    Keywords: Case - Control Studies ; Guillain - Barre Syndrome ; Influenza A Virus, H1n1 Subtype ; Influenza, Human ; Risk ; Vaccination
    ISSN: 0002-9262
    E-ISSN: 1476-6256
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  • 6
    Language: English
    In: European Journal of Pharmacology, 2002, Vol.441(1), pp.67-74
    Description: We have evaluated the effects of nefopam on the spinal c-Fos protein expression in the model of acute (noxious heat) and persistent (intraplantar injection of formalin) nociception in the rat. One and two hours after i.pl. formalin injection, c-Fos immunoreactive (c-Fos-IR) nuclei were preferentially located in the superficial (I-II) and deep (V-VI) laminae of the spinal dorsal horn of segments L4-L5, i.e. spinal areas containing numerous neurons responding exclusively, or not, to peripheral nociceptive stimuli. The doses of 15 and 30 mg/kg (s.c.) of nefopam had significant reducing effects on the formalin-evoked spinal c-Fos protein expression (36+/-14% and 47+/-9% reduction of the total number of c-Fos-IR nuclei per section, respectively, P〈0.05 for both). These reducing effects of nefopam were not detectable 2 h after formalin. These results provide evidence that the significant effects of nefopam are time-limited in the formalin model of persistent nociception. One hour after noxious heat stimulation (52 degrees C for 15 s), c-Fos-IR nuclei were principally located in the superficial laminae I-II of the spinal dorsal horn (about 90% of the total number of c-Fos-IR nuclei per section). Nefopam (15 mg/kg s.c.) significantly reduced the noxious heat-evoked spinal c-Fos protein expression (33+/-3% reduction of the total number of c-Fos-IR nuclei, P〈0.0001). The present results provide first evidence for the reducing effects of nefopam on the noxiously evoked spinal c-Fos protein expression, principally in acute nociceptive processes. These results suggest that nefopam may produce antinociceptive effects mainly in acute pain states.
    Keywords: C-Fos ; Formol ; Nefopam ; Noxious Heat ; Spinal Dorsal Horn ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0014-2999
    E-ISSN: 1879-0712
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  • 7
    Language: English
    In: European Journal of Pharmacology, 2005, Vol.514(2), pp.121-130
    Description: We studied the effects of the high-efficacy 5-hydroxytryptamine (5-HT ) receptor agonist, F 13640 on both formalin-induced spinal cord c-Fos protein expression and pain behaviours in the rat. Replicating earlier data, F 13640 (0.63 mg/kg, i.p.; ) completely inhibited the elevation and licking of the formalin-injected paw. In the same animals, and in spite of the agent as in earlier data increasing the number of c-Fos labelled nuclei when it was administered alone, F 13640 markedly reduced the number of formalin-induced c-Fos labelled nuclei. This was found in both the superficial (I–II) and deep (V–VI) dorsal horn laminae (2 h post-injection: 72 ± 2% and 92 ± 1% of reduction, respectively; 〈 0.001 in either case), spinal areas that contain neurons responsive to nociceptive stimulation. Co-operation occurred so that after the co-administration of F 13640 and formalin, c-Fos expression was inferior to that induced when either stimulation was administered alone. The data provide initial evidence for the agent's inhibitory effects on noxiously evoked c-Fos expression. The results indicate that co-operation between 5-HT receptor activation and nociceptive stimulation powerfully inhibits responses to severe, tonic nociception.
    Keywords: 5-Ht 1a Receptor ; C-Fos Protein ; Formalin ; F 13640 ; Morphine ; Rat Spinal Cord ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0014-2999
    E-ISSN: 1879-0712
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  • 8
    Language: English
    In: Pain, June 2001, Vol.92(3), pp.389-398
    Description: In a model of mononeuropathic pain (chronic constriction injury of the sciatic nerve, CCI), we have demonstrated that light touch stimuli (stroking) to the paw induced Fos-like immunoreactivity (Fos-LI) in the superficial and deep dorsal horn of the rat spinal cord (Catheline et al., Pain 80 (1999a) 347). The efficacy of opioids in neuropathic pain being controversial, we have tested the effects of morphine (0.3, 1 and 3 mg/kg intravenous, i.v.) on this spinal Fos-LI evoked by light tactile stimuli, which could be related to mechanical allodynia. Morphine did not change the level of spinal Fos-LI observed following light touch stimuli in the CCI rats (43 +/- 3, 38 +/- 7, and 37 +/- 4 Fos-LI neurones/40 microm L4-L5 section, respectively, for the three doses versus 32 +/- 4 in the control group). In contrast, the administration of 3 mg/kg of i.v. morphine reduced by 30% the number of Fos-LI neurones induced by heat stimulation (52 degrees C, 15 s duration) in CCI rats (P 〈 0.05) as in sham-operated rats. These effects were reversed by the systemic administration of naloxone. The lack of effect of morphine on touch-evoked Fos-LI in the superficial dorsal horn reinforces the assertion that dynamic mechanical allodynia is related to information transmitted by A-beta fibres, since opioid receptors are mainly located on thin primary afferent fibres. Our results provide a basis for a certain form of allodynia that is insensitive to morphine.
    Keywords: C-Fos ; Spinal Cord ; Neuropathic Pain ; Chronic Constriction Injury ; Mechanical Allodynia ; Morphine ; Medicine
    ISSN: 0304-3959
    E-ISSN: 1872-6623
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  • 9
    Language: English
    In: Pain, 1995, Vol.60(2), pp.232-233
    Keywords: Medicine
    ISSN: 0304-3959
    E-ISSN: 1872-6623
    Source: ScienceDirect Journals (Elsevier)
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  • 10
    Language: English
    In: Pain, 1996, Vol.67(2), pp.379-389
    Description: This study assesses the anti-inflammatory/analgesic effects of ketoprofen a non-steroidal anti-inflammatory drug, using the method of c-Fos immunoreactivity at the spinal cord level in two models of noxious stimulation: carrageenan-induced inflammatory pain or acute noxious heat. Ketoprofen was pre-administered intravenously or orally 25 min before an intraplantar injection of carrageenan (6 mg in 150 μ1 of saline) in hindpaw of the non-anaesthetised rat or before a single noxious heat (52°C, 15 sec) stimulation of hindpaw of the anaesthetised rat. Three hours after carrageenan or 2 h after noxious heat, the number of spinal c-Fos protein-like immunoreactive (c-Fos-LI) neurons in L4-L5 segments and both the ankle and paw diameter, the indicator of peripheral oedema, were assessed. Pre-administered ketoprofen (1, 3 and 10 mg/kg i.v.) dose-dependently blocks the development of the carrageenan-induced spinal c-Fos protein expression and peripheral oedema, with the highest dose influencing in parallel both parameters (75 ± 2% diminution of total number of c-Fos-LI neurons per L4-L5 section; 64 ± 4% and 82 ± 6% diminution of paw and ankle oedema, respectively). The effect of ketoprofen was significantly greater on the number of c-Fos-LI neurons in deep, as compared to superficial, laminae. Furthermore, the dose-dependent effects of ketoprofen on the carrageenan-induced spinal c-Fos protein expression and both the paw and ankle oedema were correlated. Oral pre-administration of ketoprofen (20 mg/kg) produced the blockage of development of the carrageenan-induced spinal c-Fos protein expression (65 ± 3% diminution of total number of c-Fos-LI neurons per L4-L5 section) and peripheral oedema (20 ± 3% and 59 ± 10% diminution of paw and ankle oedema, respectively). In contrast, the same doses of both the intravenous and oral pre-administration of ketoprofen did not influence either the spinal c-Fos protein expression nor slightly enhanced paw diameter induced by a single noxious heat stimulation. This study suggests a predominant peripheral site, without excluding a central site of action of ketoprofen in the carrageenan-induced inflammation. The method of c-Fos protein-like immunoreactivity revealed ketoprofen to be more potent in comparison to members of other families of non-steroidal anti-inflammatory drugs, previously studied in the same experimental conditions of carrageenan-induced inflammatory pain.
    Keywords: Carrageenan ; C-Fos ; Inflammatory Pain ; Ketoprofen ; Noxious Heat ; Rat ; Spinal Cord ; Medicine
    ISSN: 0304-3959
    E-ISSN: 1872-6623
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