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  • 1
    Book
    Book
    World Scientific Pub Co Pte
    Language: English
    Description: This book is a unique collaboration between a mother of a child with atopic dermatitis (AD) and the doctor who is treating the child - it offers practical information...
    Keywords: Eczema ; Dermatitis, Atopic ; Eczema ; Physician-Patient Relations;
    ISBN: 9814590711
    ISBN: 9814579513
    ISBN: 9789814590716
    ISBN: 9789814579513
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  • 2
    Article
    Article
    Language: English
    In: The Japanese Journal of Pediatric Allergy and Clinical Immunology, 2012, Vol.26(1), pp.149-149
    Description: Research on sublingual immunotherapy (SLIT) has attracted considerable attention in recent years, resulting in a large number of high-quality studies. The underlying mechanisms of SLIT remain unclear, but it seems likely that the route of allergen processing and presentation is a critical determinant for the subsequent T-cell response. Locally administrated allergen is taken up by mucosal dendritic cells (Langerhans-like cells) expressing high-affinity IgE receptors, producing IL-10 and other cytokines (the role of TGF-beta is unclear).
    ISSN: 0914-2649
    E-ISSN: 18822738
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  • 3
    Language: English
    In: British Medical Journal, July 11, 2009, Vol.339(7712), p.58(2)
    Description: The increasing prevalence of allergic diseases is highlighted in the article. Where the association between defects of the filaggrin gene and the risk of developing allergic sensitisation and allergic disorders is discussed.
    Keywords: Allergy -- Genetic Aspects ; Allergy -- Risk Factors ; Gene Mutation -- Analysis ; Genetic Disorders -- Research
    ISSN: 1759-2151
    ISSN: 09598146
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  • 4
    Language: English
    In: Asian Pacific journal of allergy and immunology, September 2013, Vol.31(3), pp.173-4
    Keywords: Bacterial Infections -- Epidemiology ; Common Variable Immunodeficiency -- Epidemiology ; Mycoses -- Epidemiology
    ISSN: 0125-877X
    E-ISSN: 22288694
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 5
    Language: English
    In: Asian Pacific journal of allergy and immunology, September 2016, Vol.34(3), pp.181-189
    Description: Allergic diseases are on the rise in Asia. Aeroallergen exposure is a strong risk factor for sensitization, development and severity of atopic diseases, especially in the Asian paediatric population. Geographical and seasonal variations in aeroallergen sensitization are seen even within Asian countries and changes in aeroallergen sensitization patterns have been observed over time. Some possible reasons include climate change as well as rapid urbanization and improved sanitation which follow socioeconomic development. House dust mite allergy is present in up to 90% of Asian atopic patients, far exceeding that which is seen in Western populations which report prevalences of only 50% to 70%. Pollen and animal dander affect less than 10% of Asian patients as compared to 40-70% of individuals with asthma and allergic rhinitis living in the West, a burden almost equivalent to the dust mite burden in those regions. There is thus a pressing need for preventive measures to reduce dust mite sensitization in Asian children today.
    Keywords: Air Pollutants -- Adverse Effects ; Allergens -- Adverse Effects ; Hypersensitivity -- Epidemiology
    ISSN: 0125-877X
    E-ISSN: 22288694
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  • 6
    Language: English
    In: Postgraduate Medical Journal, 30 September 2014, Vol.90(1067), p.488
    Description: Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a specific form of wheat allergy caused by the combination of wheat ingestion and physical exercise and has been reported in other parts of Asia. At present, there are no published reports of WDEIA in Singapore. The objective of this study is to characterise the common local clinical and laboratory manifestations of WDEIA.
    Keywords: Anaphylaxis–Diagnosis ; Diagnosis, Differential–Epidemiology ; Directive Counseling–Etiology ; Exercise–Adverse Effects ; Female–Pharmacology ; Gliadin–Epidemiology ; Humans–Complications ; Male–Diagnosis ; Patient Education As Topic–Epidemiology ; Recurrence–Epidemiology ; Retrospective Studies–Epidemiology ; Singapore–Epidemiology ; Skin Tests–Epidemiology ; Tertiary Care Centers–Epidemiology ; Wheat Hypersensitivity–Epidemiology ; Gliadin;
    ISSN: 0032-5473
    ISSN: 00325473
    E-ISSN: 1469-0756
    E-ISSN: 14690756
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  • 7
    Language: English
    In: Asian Pacific journal of allergy and immunology, September 2013, Vol.31(3), pp.190-7
    Description: To determine the use and efficacy of sublingual immunotherapy (SLIT) for house dust mite (HDM) allergies in Southeast Asian children. Aliterature search was performed in Pubmed and the Asian Pacific Journal of Allergy and Immunology. We also evaluated the literature for similar studies performed in Asia. Clinical trials involving children that assess SLIT for HDM allergies in Southeast Asia and Asia. There are no published studies on the use of SLIT for HD Mallergies in Southeast Asian children. However, there are seven studies from Asia which show that there are discrepancies over the benefits of SLIT for HDM allergies in Asian children. Limitations in these studies include small sample sizes and short study periods. We cannot say with certainty what the impact of SLIT is on HDM allergies in Southeast Asian children due to the lack of data. The available studies performed in Asia have their limitations but are suggestive of the potential of SLIT for HDM allergies in Southeast Asian children. This review highlights that good quality clinical research in this area in the Southeast Asian setting is warranted.
    Keywords: Administration, Sublingual ; Immunotherapy ; Pyroglyphidae ; Hypersensitivity -- Therapy
    ISSN: 0125-877X
    E-ISSN: 22288694
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 8
    Language: English
    In: Singapore medical journal, November 2015, Vol.56(11), pp.622-5
    Description: The prevalence of perceived food allergies exceeds that of true food allergies. Unnecessary food avoidance may increase parental and patient anxiety, reduce quality of life and increase the risk of nutritional deficiency. An oral food challenge (OFC) can provide an objective measure regarding the presence or absence of food allergies in a child. This study reviews the indications for and outcomes of OFCs performed on children. A retrospective review was performed on all children who underwent OFCs at the Allergy Unit of the National University Hospital, Singapore, over a three-year period. A total of 197 OFCs were performed among 58 patients (34 male, 24 female). Most of the tests were for allergies to tree nuts (n = 107). Among the OFCs, 43.1% were for foods that were avoided and never eaten due to perceived food allergies, 25.9% were for foods that had previously resulted in positive skin prick tests (SPTs) and/or immunoassay results, 16.2% were for foods thought to worsen eczema and 14.7% were for foods thought to have caused a previous reaction. Of all the OFCs, 5% were positive, although adverse reactions were mostly cutaneous. Challenge-positive patients had either positive SPTs (wheal 〉 3 mm) or raised serum immunoglobulin E levels to specific foods that they reacted to during the challenges. No episodes of anaphylaxis were reported after the challenge. Most of the patients were able to safely introduce the avoided foods into their diets. OFCs provide an objective assessment for suspected food allergies.
    Keywords: Food Allergy ; Indications ; Oral Food Challenges ; Outcomes ; Safety ; Quality of Life ; Tertiary Care Centers ; Food -- Adverse Effects ; Food Hypersensitivity -- Epidemiology
    ISSN: 0037-5675
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  • 9
    Article
    Article
    British Medical Journal Publishing Group
    Language: English
    In: BMJ, 9, 9 July July 2009, Vol.339
    Description: Identifying specific genotypes of allergy is a major breakthrough in patient care
    Keywords: Patients ; Immunology (Including Allergy) ; Child Health ; Asthma ; Dermatology ; Ear, Nose and Throat/Otolaryngology
    ISSN: 0959-8138
    ISSN: 09598138
    E-ISSN: 1468-5833
    E-ISSN: 14685833
    E-ISSN: 17561833
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  • 10
    Language: English
    In: Pediatric Allergy and Immunology, August, 2011, Vol.22(5), p.488(6)
    Description: To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1399-3038.2011.01149.x Byline: Woei Kang Liew (1), Chee Wen Terence Lim (2), Teng Hong Tan (1), Keng Yean Wong (1), Bee Choo Tai (3), Swee Chye Quek (2), Hugo van Bever (2) Keywords: Kawasaki disease; allergies; children Abstract: To cite this article: Liew WK, Lim CWT, Tan TH, Wong KY, Tai BC, Quek SC, Bever HV. The effect of Kawasaki disease on childhood allergies - a sibling control study. Pediatr Allergy Immunol 2011; 22: 488-493. Abstract Objective: Kawasaki disease (KD) is a multisystem inflammatory vasculitis of childhood, with widespread T-helper cell type 1 immune activation. We hypothesize that children who suffered from KD will have a lower risk of developing allergic diseases. Study design: This was a cross-sectional study, recruiting children with a history of KD, together with well sibling controls. All children underwent the standardized core ISAAC questionnaire for allergy, physical examination and skin prick test evaluation. McNemar's test was employed to evaluate the effect of Kawasaki disease on allergy. Multivariable analysis based on mixed-effects logistic regression model was used to adjust for potential confounding effect of age and gender. Results: One hundred and eighty-six children (93 KD sibling pairs) completed the above evaluation. Allergic rhinitis was more common in patients with KD (crude OR 2.40; 95% CI 1.11-5.62, p = 0.024) when compared with controls. The effect was further intensified after accounting for the potential confounding effect of age and gender (adjusted OR = 2.90; 95% CI 1.27-6.60). Children in whom KD occurred beyond the age of 12 months had more allergic rhinitis (crude OR 4.00, 95% CI 1.29-16.44, p = 0.012), 'any' allergies (crude OR 3.75, 95% CI 1.19-15.52, p = 0.019) and Blomia tropicalis sensitization (crude OR 2.57, 95% CI 1.02-7.28, p = 0.043) when compared with their sibling controls. Interestingly, children in whom KD course resulted in no coronary artery abnormalities have more allergic rhinitis (crude OR 8.50, 95% CI 2.02-75.85, p = 0.003) and 'any' allergies (crude OR 5.00, 95% CI 1.41-26.94, p = 0.011), when compared with their sibling controls. Conclusion: Kawasaki disease may be a risk factor for subsequent allergic diseases. We postulate that KD occurs more frequently in children at risk of immune disequilibrium, with an abnormal inflammatory response initially, and subsequently more allergic manifestations. Author Affiliation: (1)Department of Paediatrics Medicine, KK Women's & Children's Hospital, Singapore (2)Department of Paediatrics Medicine, National University Hospital, Singapore (3)Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Article History: Accepted for publication 19 January 2011 Article note: Liew Woei Kang, Department of Pediatric Medicine, KK Women's and Children's Hospital, Singapore., Tel.: +65 63941039, Fax: +65 63941043, E-mail: liew.woei.kang@kkh.com.sg
    Keywords: Medical Schools -- Analysis ; Kawasaki Syndrome -- Development And Progression ; Kawasaki Syndrome -- Risk Factors ; Kawasaki Syndrome -- Analysis ; Child Health -- Analysis ; Medical Research -- Analysis ; Pediatric Allergy -- Development And Progression ; Pediatric Allergy -- Risk Factors ; Pediatric Allergy -- Analysis
    ISSN: 0905-6157
    E-ISSN: 13993038
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