UID:
almafu_9960074094502883
Format:
1 online resource (2,034 pages)
Edition:
Fourth edition.
ISBN:
0-12-814842-X
,
0-12-814841-1
Content:
"Preface from the first edition (1996): "The world of modern science is undergoing a number of spectacular events that are redefining our understanding of ourselves. As with any revolution, we should take stock of where we have been, where we are, and where we are going. Our special world of bone biology is participating in and taking advantage of the larger global revolution in modern science... we assembled experts from all over the world and asked them to focus on the current state of knowledge and the prospects for new knowledge in their area of expertise. To this end, Principles of Bone Biology was conceived." - John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan Praise for the previous edition: "Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently." --The New England Journal of Medicine"--
Note:
Includes index.
,
9780128148426v1_WEB -- Front Cover -- I - Basic principles -- A - Cell biology -- 1 - Molecular and cellular regulation of intramembranous and endochondral bone formation during embryogenesis -- Introduction -- The limb skeleton -- Proximal-distal axis -- Mesenchymal condensation and patterning of the skeleton -- Endochondral bone formation -- Overview -- Mediators of skeleton formation -- Local mediators -- Growth factor signaling pathways -- Transforming growth factor β and bone morphogenetic proteins -- WNTs and β-catenin -- Transcription factors -- Epigenetic factors and microRNAs -- The functional roles of the vasculature in endochondral bone formation -- References -- 2 - Skeletal stem cells: tissue-specific stem/progenitor cells of cartilage, bone, stroma, and marrow adipocytes -- Introduction -- The skeletal lineage -- Regulation of SSC/BMSC fate -- Epigenetic controls -- Characterization of SSCs/BMSCs -- Potency -- 3 - Bone marrow and the hematopoietic stem cell niche -- The adult bone marrow niche -- Hematopoietic cells -- Macrophages -- Neutrophils -- Neuronal regulation of the hematopoietic stem cell niche -- Hormonal regulation of the hematopoietic stem cell niche -- Parathyroid hormone -- 4 - The osteoblast lineage: its actions and communication mechanisms -- The stages of the osteoblast lineage -- Commitment of osteoblast progenitors (preosteoblasts) -- At their various stages of development, cells of the osteoblast lineage signal to one another -- An example of contact-dependent communication: EphrinB2/EphB4 -- Communication at different stages of differentiation: PTHrP/PTHR1 -- Lessons in osteoblast biology from the Wnt signaling pathway -- References -- 5 - Osteoclasts -- Function of osteoclasts -- DC-STAMP/OC-STAMP -- Signal transduction in osteoclastogenesis -- The M-CSF receptor FMS -- Tumor necrosis factor receptors.
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Induction of osteoclast function -- Adhesion signals -- Conclusion and perspective -- 6 - The osteocyte -- The osteocytic phenotype -- Osteocytic cell lines -- Matrix synthesis -- Hormone receptors in osteocytes -- Osteocyte function -- Blood-calcium/phosphate homeostasis -- Osteocytes as mechanosensory cells -- Canalicular fluid flow and osteocyte mechanosensing -- Response of osteocytes to fluid flow in vitro -- Summary and conclusion -- 7 - Transcriptional control of osteoblast differentiation and function -- Runx2, a master control gene of osteoblast differentiation in bony vertebrates -- Osterix, a Runx2-dependent osteoblast-specific transcription factor required for bone formation -- 8 - Wnt signaling and bone cell activity -- Wnt genes and proteins -- Components of the Wnt/β-catenin signaling pathway -- Dishevelled, glycogen synthase kinase-3β, Axin, and β-catenin -- Wnt signaling and bone cell function -- Osteoblast differentiation and function -- Osteocyte function -- Interactions between Wnt/β-catenin signaling and other pathways important in bone mass regulation -- 9 - Vascular and nerve interactions -- The nerve system of bone -- Innervation of developing bone -- Innervation of the mature skeleton -- Somatic nervous system -- Autonomic nervous system -- 10 - Coupling of bone formation and resorption -- Development of the concept of coupling -- Coupling and balance: what is the difference? -- Coupling factors synthesized and secreted by osteoclasts -- How other cells contribute to coupling -- References -- 11 - Modeling and remodeling: the cellular machinery responsible for bone's material and structural strength d ... -- Summary -- Bone remodeling by the basic multicellular unit -- The bone remodeling compartment -- Bone remodeling and microstructure during young adulthood, menopause, and advanced age.
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Young adulthood: reversible bone loss and microstructural deterioration -- Advanced age: the predominance of cortical bone loss -- Bone modeling, remodeling, and drug therapy -- Combined antiresorptive and anabolic therapy -- Conclusion -- 12 - Aging and bone -- Characteristics of the aged skeleton -- Human -- Bone cell aging -- Osteocytes -- Molecular mechanisms of aging -- Mitochondrial dysfunction -- Loss of autophagy -- Contribution of bone extrinsic mechanisms to skeletal aging -- Future directions -- B - Biochemistry -- 13 - Type I collagen structure, synthesis, and regulation -- Introduction -- Structure, biosynthesis, transport, and assembly of type I collagen -- Regulation of transcription -- Assembly -- Posttranscriptional regulation of type I collagen -- Critical factors involved in type I collagen gene regulation -- Growth factors -- Connective tissue growth factor -- Fibroblast growth factor -- Cytokines -- Interferon γ -- Other cytokines -- Interleukin 13 -- Arachidonic acid derivatives -- 14 - Collagen cross-linking and bone pathobiology -- Introduction -- Cross-link formation -- Bone collagen cross-linking -- Cross-link structures -- Divalent cross-links -- Pyrrole cross-links -- Glycosylations and glycations -- Nonspecific glycations -- Potential consequences -- Cross-linking lysine-modifying enzymes -- Lysyl hydroxylases -- Consequences of lysyl hydroxylase gene mutations -- Lysyl oxidases -- Heritable disorders and mouse models -- Heritable disorders -- Collagen posttranslational modifications -- SC65 and P3H3 -- Collagen processing -- Collagen chaperone -- 15 - Secreted noncollagenous proteins of bone -- Introduction -- Glycoproteins -- Alkaline phosphatase -- Sclerostin -- Osteonectin (SPARC, culture shock protein, and BM40) -- Tetranectin -- RGD-containing glycoproteins.
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Irisin (FRCP2, fibronectin type III domain-containing protein 5) -- Small integrin-binding ligands with N-linked glycosylation -- Dentin matrix protein 1 -- Matrix extracellular phosphoglycoprotein -- 16 - Bone proteinases -- Metalloproteinases -- Membrane-type matrix metalloproteinases -- 17 - Integrins and other cell surface attachment molecules of bone cells -- Role of integrins in bone cells -- Osteoblasts and osteocytes -- Role of cadherins in bone cells -- Osteoblasts and osteocytes -- Osteoclasts -- Roles of other attachment molecules in bone cells -- Glypicans and perlecan -- Immunoglobulin superfamily members -- ACKNOWLEDGMENTS -- References -- 18 - Intercellular junctions and cell-cell communication in the skeletal system -- Adherens junctions and the cadherin superfamily of cell adhesion molecules -- N-cadherin modulation of Wnt/β-catenin signaling in osteoblastogenesis and osteoanabolic responses -- Connexins and gap-junctional intercellular communication -- Connexin diseases affecting the skeleton -- C - Bone remodeling and mineral homeostasis -- 19 - Histomorphometric analysis of bone remodeling -- Tetracycline labeling and the surgical procedure -- Routine histomorphometric variables -- Static parameters -- Clinical indications for bone biopsy -- Histomorphometric studies of the effects of osteoporosis drugs -- Anticatabolic agents -- Selective estrogen receptor modulators -- Denosumab -- PTH(1-34) and PTH(1-84) -- Abaloparatide -- 20 - Phosphorus homeostasis and related disorders -- Regulation of phosphate metabolism -- Overview -- The role of osteocytes -- Phosphate and bone mineralization -- Mechanisms of phosphate transport -- Intestinal phosphate transport -- Primary disorders of phosphate homeostasis -- Fibroblast growth factor 23-mediated hypophosphatemic disorders -- X-linked hypophosphatemia (OMIM: 307800).
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Autosomal dominant hypophosphatemic rickets (OMIM: 193100) -- Autosomal recessive hypophosphatemic rickets -- Fibroblast growth factor 23-independent hypophosphatemic disorders -- Hereditary hypophosphatemic rickets with hypercalciuria (OMIM: 241530) -- Clinical presentation and diagnostic evaluation -- Laboratory findings and genetic testing -- Therapy and resources -- Standard therapy -- Fanconi-Bickel syndrome (OMIM: 227810) -- Hyperphosphatemic syndromes -- Tumoral calcinosis -- Summary -- 22 - Metal ion toxicity in the skeleton: lead and aluminum -- Introduction -- Research into bone-seeking toxic elements -- Lead -- Mechanism of action of lead: stimulation of sclerostin expression -- A clinical opportunity -- Aluminum -- Summary -- 23 - Biology of the extracellular calcium-sensing receptor -- Agonists, antagonists, and modulators of the calcium-sensing receptor -- Cationic agonists of the calcium-sensing receptor -- Synthetic modulators -- Roles of calcium-sensing receptor in calciotropic tissues -- Calcium-sensing receptor in the kidney -- Calcium-sensing receptor in bone cells -- Calcium-sensing receptor in the breast -- D - Endocrine and paracrine regulation of bone -- 24 - Parathyroid hormone molecular biology -- The parathyroid hormone gene -- Organization of the parathyroid hormone gene -- The parathyroid hormone mRNA -- Mutations in the parathyroid hormone gene -- Development of the parathyroid -- Regulation of parathyroid hormone gene expression -- Phosphate -- Protein-PTH mRNA interactions determine the posttranscriptional regulation of PTH gene expression by calcium, phosphate, an ... -- Fibroblast growth factor 23 -- Resistance of the parathyroid to FGF23 in chronic kidney disease -- References -- 25 - Paracrine parathyroid hormone-related protein in bone: physiology and pharmacology.
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PTHrP in fetus: early development and endochondral ossification.
Language:
English
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