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Berlin Brandenburg

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  • 1
    Article
    Article
    Language: English
    In: Clinics in Laboratory Medicine, September 2017, Vol.37(3), pp.xiii-xiii
    Keywords: Medicine
    ISSN: 0272-2712
    E-ISSN: 1557-9832
    Source: ScienceDirect Journals (Elsevier)
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  • 2
    Language: English
    In: The Lancet, 02 May 2015, Vol.385(9979), pp.1777-1777
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0140-6736(14)61902-4 Byline: Elena Gonzalez, Steven D Billings, Anthony P Fernandez Author Affiliation: (a) Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, OH, USA (b) Departments of Pathology and Dermatology, Cleveland Clinic, Cleveland, OH, USA
    Keywords: Medicine
    ISSN: 0140-6736
    E-ISSN: 1474-547X
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  • 3
    In: Circulation, 2014, Vol.130(15), pp.1300-1302
    Keywords: Aged–Diagnosis ; Aortic Aneurysm, Abdominal–Drug Therapy ; Comorbidity–Therapeutic Use ; Female–Diagnosis ; Humans–Drug Therapy ; Prednisone–Drug Therapy ; Retroperitoneal Fibrosis–Drug Therapy ; Tomography, X-Ray Computed–Drug Therapy ; Treatment Outcome–Drug Therapy ; Abridged ; Prednisone;
    ISSN: 0009-7322
    E-ISSN: 15244539
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  • 4
    Article
    Article
    Language: English
    In: Clinics in Laboratory Medicine, September 2017, Vol.37(3), pp.i-i
    Keywords: Medicine
    ISSN: 0272-2712
    E-ISSN: 1557-9832
    Source: ScienceDirect Journals (Elsevier)
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  • 5
    Article
    Article
    Language: English
    In: Clinics in Laboratory Medicine, 2011, Vol.31(2), pp.xi-xii
    Keywords: Medicine
    ISSN: 0272-2712
    E-ISSN: 1557-9832
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  • 6
    In: Pathology, 2014, Vol.46 Abstracts: RCPA Pathology Update 2014 IAP Australasian Division 38th Annual Scientific Meeting, pp.S8-S8
    Description: Melanocytic tumours are arguably the most important aspect of dermatopathology. This course will cover a range of issues encountered in the practice of surgical pathology related to melanocytic lesions. Laboratory issues such as embedding and fixation artifacts, topics not commonly discussed in textbooks, will be addressed. In addition, other situations that cause diagnostic difficulty will be discussed, including margin assessment in sun damaged skin, naevi that histologically mimic melanoma, naevoid melanoma, and desmoplastic melanoma. A practical approach and strategies to resolve the differential diagnosis will be emphasised.
    Keywords: Medicine ; Biology;
    ISSN: 1465-3931
    ISSN: 00313025
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  • 7
    Language: English
    In: The American Journal of Surgical Pathology, 2013, Vol.37(8), p.1298
    ISSN: 0147-5185
    Source: Wolters Kluwer - Ovid - Lippincott Williams & Wilkins (via CrossRef)
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  • 8
    In: Pathology, 2014, Vol.46 Abstracts: RCPA Pathology Update 2014 IAP Australasian Division 38th Annual Scientific Meeting, pp.S7-S8
    Description: Diagnosis of inflammatory diseases of the skin is vexing for general surgical pathologists. There is considerable overlap in histologic features, and the terminology in dermatopathology often seems impenetrable. This course will cover a wide range of inflammatory diseases of the skin that may be encountered by the germinal surgical pathologist. A practical approach utilising reaction patterns will be emphasised, including spongiotic, psoriasiform, interface, perivascular, nodular, palisading granulomatous, panniculitis, and bullous diseases. During the course, practical tips and strategies to construct effective reports even in the setting of non-specific findings will be provided. By the end of the course, the participants will hopefully be able to approach inflammatory disease of the skin with less trepidation.
    Keywords: Medicine ; Biology;
    ISSN: 1465-3931
    ISSN: 00313025
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  • 9
    Article
    Article
    In: Pathology, 2014, Vol.46 Abstracts: RCPA Pathology Update 2014 IAP Australasian Division 38th Annual Scientific Meeting, pp.S8-S8
    Description: Vascular tumours are a significant source of diagnostic difficulty that often vex surgical pathologists. This course will cover a range of vascular tumours that can have deceptive histologic features, including benign vascular tumours that can be mistaken for malignancy and deceptive vascular tumours that do not appear to be vascular tumours at all. This course will emphasise histologic features and a practical approach to the differential diagnoses.
    Keywords: Medicine ; Biology;
    ISSN: 1465-3931
    ISSN: 00313025
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  • 10
    Language: English
    In: Anand, Sanjay, John Ebner, Christine B. Warren, Manu S. Raam, Melissa Piliang, Steven D. Billings, and Edward V. Maytin. 2014. “C/EBP Transcription Factors in Human Squamous Cell Carcinoma: Selective Changes in Expression of Isoforms Correlate with the Neoplastic State.” PLoS ONE 9 (11): e112073. doi:10.1371/journal.pone.0112073. http://dx.doi.org/10.1371/journal.pone.0112073.
    Description: The CCAAT/Enhancer Binding Proteins (C/EBPs) are a family of leucine-zipper transcription factors that regulate physiological processes such as energy metabolism, inflammation, cell cycle, and the development and differentiation of several tissues including skin. Recently, a role for C/EBPs in tumor cell proliferation and differentiation has been proposed, but the incomplete characterization in the literature of multiple translational isoforms of these proteins has made interpretation of these roles difficult. Therefore, we have carefully reexamined C/EBP isoform expression in human non-melanoma skin cancers. C/EBPα, C/EBPβ, and C/EBPδ were analyzed histologically in squamous cell carcinomas (SCC). The individual isoforms of C/EBPα and C/EBPβ were examined by immunofluorescent digital imaging, western blotting and DNA binding activity (electrophoretic mobility shift analysis). Expression of all C/EBP family proteins was decreased in SCC tumors. Suppression was greatest for C/EBPα, less for C/EBPβ, and least for C/EBPδ. Western analyses confirmed that C/EBPα p42 and p30 isoforms were decreased. For C/EBPβ, only the abundant full-length isoform (C/EBPβ−1, LAP*, 55 kD) was reduced, whereas the smaller isoforms, C/EBPβ−2 (LAP, 48 kD) and C/EBPβ−3 (LIP, 20 kD), which are predominantly nuclear, were significantly increased in well- and moderately-differentiated SCC (up to 14-fold for C/EBPβ−3). These elevations correlated with increases in PCNA, a marker of proliferation. Although C/EBPβ displayed increased post-translational modifications in SCC, phosphorylation of C/EBPβ−1 (Thr 235) was not altered. C/EBP-specific DNA binding activity in nuclear and whole-cell extracts of cultured cells and tumors was predominantly attributable to C/EBPβ. In summary, two short C/EBPβ isoforms, C/EBPβ−2 and C/EBPβ−3, represent strong candidate markers for epithelial skin malignancy, due to their preferential expression in carcinoma versus normal skin, and their strong correlation with tumor proliferation.
    Keywords: Medicine And Health Sciences ; Dermatology ; Skin Neoplasms ; Oncology ; Basic Cancer Research ; Cancer Risk Factors ; Cancers And Neoplasms
    ISSN: 1932-6203
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