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  • 1
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 25 January 2011, Vol.108(4), pp.1445-50
    Description: Keratin 8 (K8) is a major intermediate filament protein present in enterocytes and serves an antiapoptotic function in hepatocytes. K8-null mice develop colonic hyperplasia and colitis that are reversed after antibiotic treatment. To investigate the pathways that underlie the mechanism of colonocyte hyperplasia and the normalization of the colonic phenotype in response to antibiotics, we performed genome-wide microarray analysis. Functional annotation of genes that are differentially regulated in K8(-/-) and K8(+/+) isolated colon crypts (colonocytes) identified apoptosis as a major altered pathway. Exposure of K8(-/-) colonocytes or colon organ ("organoid") cultures, but not K8(-/-) small intestine organoid cultures, to apoptotic stimuli showed, surprisingly, that they are resistant to apoptosis compared with their wild-type counterparts. This resistance is not related to inflammation per se because T-cell receptor α-null (TCR-α(-/-)) and wild-type colon cultures respond similarly upon induction of apoptosis. Following antibiotic treatment, K8(-/-) colonocytes and organ cultures become less resistant to apoptosis and respond similarly to the wild-type colonocytes. Antibiotics also normalize most differentially up-regulated genes, including survivin and β4-integrin. Treatment of K8(-/-) mice with anti-β4-integrin antibody up-regulated survivin, and induced phosphorylation of focal adhesion kinase with decreased activation of caspases. Therefore, unlike the proapoptotic effect of K8 mutation or absence in hepatocytes, lack of K8 confers resistance to colonocyte apoptosis in a microflora-dependent manner.
    Keywords: Anti-Bacterial Agents -- Pharmacology ; Apoptosis -- Drug Effects ; Colon -- Drug Effects ; Keratin-8 -- Physiology
    ISSN: 00278424
    E-ISSN: 1091-6490
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  • 2
    Article
    Article
    Language: English
    In: The Journal of Urology, March 2017, Vol.197(3), pp.850-850
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.juro.2016.08.147 Byline: Bishr Haydar Author Affiliation: Section of Pediatric Anesthesia, Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
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  • 3
    Language: English
    In: Anesthesiology, 2015, Vol.122(6), p.1445
    ISSN: 0003-3022
    E-ISSN: 15281175
    Source: Wolters Kluwer - Ovid - Lippincott Williams & Wilkins (via CrossRef)
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  • 4
    Language: English
    In: Gut, April, 2012, Vol.61(4), p.632(2)
    Keywords: Pancreatitis -- Care And Treatment ; Pancreatitis -- Reports ; Mast Cells -- Physiological Aspects ; Mast Cells -- Control ; Heme -- Physiological Aspects
    ISSN: 0017-5749
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  • 5
    Language: English
    In: Gastroenterology, May 2016, Vol.150(5), pp.1067-1070
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1053/j.gastro.2016.03.001 Byline: M. Bishr Omary Author Affiliation: Department of Molecular and Integrative Physiology, Department of Medicine, University of Michigan and VA Ann Arbor Health Care System, Ann Arbor, Michigan Article Note: (footnote) Conflicts of interest The author discloses no conflicts.
    Keywords: Medicine
    ISSN: 0016-5085
    E-ISSN: 1528-0012
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  • 6
    Language: English
    In: Gastroenterology, June 2016, Vol.150(7), pp.1496-1502
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1053/j.gastro.2016.04.005 Byline: M. Bishr Omary Author Affiliation: Editor, Gastroenterology
    Keywords: Medicine
    ISSN: 0016-5085
    E-ISSN: 1528-0012
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  • 7
    Language: English
    In: Gastroenterology, June 2016, Vol.150(7), pp.1503-1504
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1053/j.gastro.2016.03.034 Byline: M. Bishr Omary Author Affiliation: Gastroenterology Article Note: (footnote) Conflicts of interest The authors disclose no conflicts.
    Keywords: Medicine
    ISSN: 0016-5085
    E-ISSN: 1528-0012
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  • 8
    Language: English
    In: Gastroenterology, 2011, Vol.141(1), pp.4-7
    Keywords: Medicine
    ISSN: 0016-5085
    E-ISSN: 1528-0012
    Source: ScienceDirect Journals (Elsevier)
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  • 9
    Language: English
    In: International Journal of Radiation Oncology, Biology, Physics, 01 November 2018, Vol.102(3), pp.490-498
    Description: Access to radiation facilities in low- and middle-income countries (LMIC) is far from optimal. Latin America and Africa represent 55% of LMIC, and radiation therapy facilities are available in only 70% and 46% of the countries, respectively. Only 3 countries in both regions meet the International Atomic Energy Agency's recommendation of 250,000 population per megavoltage machine (MVM). In Africa, the mean population served by 1 MVM is 3.56 million, compared with 0.65 million in Latin America. The distribution of radiation facilities in both regions varies according to income group. In Latin America, lower-middle-income countries have a distribution of 1.64 million inhabitants per MVM, as opposed to 0.64 and 0.49 million inhabitants per MVM in upper-middle- and high-income countries, respectively. In Africa, a distribution of 39.8, 2.47, and 0.8 million people per MVM is present in low-, lower-middle-, and upper-middle-income countries, respectively. Significant correlations were clearly demonstrated between population per MVM and gross domestic product (GDP) per capita (r = −0.3,  = .014), percentage of current health expenditure from GDP (r = −0.4,  = .014), life expectancy (r = −0.5,  = .0007), and cancer mortality incidence ratio (r = 0.4,  = .003). Stepwise multivariate regression showed that life expectancy was the only statistically significant factor (  = .001). These findings may indicate the detrimental impact of low radiation therapy coverage on life expectancy and cancer mortality incidence ratio in LMIC. It is noteworthy that in Latin America, a significant negative correlation was noted between population per MVM and GDP per capita (r = −0.6,  = .0004), as opposed to Africa (r = −0.4,  = .075). This indicates that African countries face challenges other than income level in addressing radiation therapy needs. More international efforts are urgently required to address the crisis of unmet radiation therapy needs in LMIC.
    Keywords: Medicine
    ISSN: 0360-3016
    E-ISSN: 1879-355X
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  • 10
    Article
    Article
    In: Nature Reviews Molecular Cell Biology, 2015
    Keywords: Animals–Pathology ; Cell Biology–Genetics ; Disease–Metabolism ; Disease Models, Animal–Metabolism ; Humans–Metabolism ; Intermediate Filaments–Metabolism ; Keratins–Metabolism ; Keratins;
    ISSN: 1471-0072
    E-ISSN: 14710080
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