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  • 1
    Language: English
    In: Experimental and Therapeutic Medicine/2011, Vol.2(2), pp.301-307
    Description: Valproate (VPA) is a well-characterized histone deacetylase inhibitor with anti-neoplastic properties. We analyzed the growth blocking effects and the molecular mode of action of this compound in colorectal cancer cells in vitro and in vivo . Caco-2, SW-480, CX-1 or WIDR cell lines were exposed to VPA (0.25–2 mM) for various time periods. Cell growth, cell cycle progression and apoptosis were analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide dye reduction assay and flow cytometry. Cell cycle- and apoptosis-regulating proteins and histone acetylation were assessed by Western blotting. In vivo tumor growth and regulating protein expression under VPA were investigated in a subcutaneous xenograft tumor model. VPA inhibited the growth of all cell lines with cell cycle arrest paralleled by the up-regulation of H3 and H4 acetylation. In vivo tumor growth was substantially depressed by VPA (200 mg/kg bw). Cell cycle proteins (cdk1, cdk2, cdk4, cyclin D, cyclin E, p19, p21 and p27) were differentially altered by VPA. Predominantly cdk1 was decreased and p27 was up-regulated in all models. Apoptosis-related proteins were altered in vivo with up-regulation of bax and down-regulation of bcl-2. VPA exerts anti-neoplastic activity in colorectal tumor cell lines in vitro and in vivo by altering cell cycle regulation.
    Keywords: Valproic Acid ; Tumor Cell Lines ; Histone Deacetylase Inhibition ; Colorectal Cancer
    ISSN: 1792-0981
    E-ISSN: 1792-1015
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  • 2
    Language: English
    In: The Journal of Urology, April 2012, Vol.187(4), pp.e130-e130
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
    Source: ScienceDirect Journals (Elsevier)
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  • 3
    Language: English
    In: The Journal of Urology, April 2012, Vol.187(4), pp.e180-e180
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
    Source: ScienceDirect Journals (Elsevier)
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  • 4
    Language: English
    In: The Journal of Urology, April 2013, Vol.189(4), pp.e70-e70
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
    Source: ScienceDirect Journals (Elsevier)
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  • 5
    Language: English
    In: The Journal of Urology, April 2011, Vol.185(4), pp.e96-e96
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
    Source: ScienceDirect Journals (Elsevier)
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  • 6
    Language: English
    In: The Journal of Urology, 2010, Vol.183(4), pp.e34-e34
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
    Source: ScienceDirect Journals (Elsevier)
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  • 7
    Language: English
    In: International Journal of Rock Mechanics and Mining Sciences, 2015, Vol.77, p.77(12)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ijrmms.2015.03.012 Byline: R. Blaheta, R. Kohut, A. Kolcun, K. Soucek, L. Stas, L. Vavro Abstract: The presented paper describes procedures of numerical upscaling and experience with X-ray CT based finite element (FEM) analysis of properties of geocomposites. The upscaling technique is used for obtaining the macro-level response of material by loading test (representative) volumes with described micro-level structure. The application is focused on geocomposites arising from chemical grouting of coal substances. The obtained (homogenized) macro-level properties serve for solving stability problems by numerical modeling in geotechnical engineering. The paper touches several interacting topics - numerical upscaling and understanding to its results; application of X-ray computed tomography (CT) for visualization of structure of geomaterials; processing the digital image data for constructing FEM models of test volumes; numerical testing of digitalized samples for obtaining homogenized properties and clearing up sensitivity to changes in local material properties, micro-level structure and FE mesh; validation of numerical results by comparison with laboratory testing of samples; use of identification technique for refining the local material properties and calibration of the upscaling procedure. Author Affiliation: Institute of Geonics AS CR, v.v.i., Ostrava-Poruba, the Czech Republic Article History: Received 3 February 2012; Revised 26 February 2015; Accepted 7 March 2015
    Keywords: Visualization (Computer)
    ISSN: 1365-1609
    Source: Cengage Learning, Inc.
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  • 8
    Book chapter
    Book chapter
    Bentham Science Publishers Ltd.
    Language: English
    In: Efficient Preconditioned Solution Methods for Elliptic Partial Differential Equations, pp.i-ii
    Description: The present book is a collection of chapters written by outstanding specialists, and is devoted to one of the most challenging topics of contemporary numerical mathematics. The topic ? development of efficient preconditioners and solution methods for (discretized) elliptic partial differential equations ? is crucial for the mathematical modelling of complex physical and other processes in most branches of science and engineering. Efficient solution methods usually arise as a combination of a suitable iterative technique and an efficient preconditioner, which is typically problem specific, using a proper approximation to the solved problem with further attributes as cheap actions with it, a possibility of parallel implementation, numerical and parallel scalability and robustness with respect to the problem parameters. The development of preconditioners has now its own history starting from matrix splittings, diagonal scaling and incomplete factorization for model elliptic problems and continuing with multigrid and multilevel methods, approximate inverses, domain decomposition methods and other approaches to the solution of complicated elliptic problems discretized by the finite element or other discretization methods. A substantial progress in the field of preconditioners has been achieved, but at the same time many new questions and challenges have arisen, and this is why the research is even more intensive nowadays than it was previously. The present book covers many topics of the contemporary research in the field of efficient preconditioners, namely: Chapter 1, written by P. Boyanova and S. Margenov, concerns the Algebraic Multilevel Iterative (AMLI) methods first introduced by Axelsson and Vassilevski. The paper overviews the methods with a special care of efficiency and robustness as well as application to both elliptic and parabolic problems discretized by either conforming or nonconforming finite element methods......
    Source: Bentham Science Publishers
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  • 9
    Language: Czech
    In: Český finanční a účetní časopis, 2013
    Description: Článek se zabývá problematikou ocenění akciových trhů v průběhu nedávné finanční krize optikou FED modelu. Ačkoli tento model má poměrně dobrou vypovídací schopnost na historických datech od roku 1979 do roku 2002, jeho predikční schopnost v průběhu poslední finanční krize, která nastala v letech 2007 až 2009, se značně zhoršila. V předkládané studii jsou rovněž nastíněny vybrané modifikace FED modelu a analyzována jejich predikční schopnost identifikovat finanční krizi a diskutovány ekonomické fundamenty, které zapříčinily zhoršení vypovídací hodnoty modelu. Příspěvek se rovněž zabývá teoretickými nedostatky FED modelu.
    Description: The paper deals with problems related to valuation of equity capital markets using a well known FED model. Although the model has a relatively good explanatory power on historical data starting from 1979 to 2002, the recent development during the last financial crisis which started in 2007 and finished in 2009 resulted in significant deterioration of the models’ usefulness for forecasting. We also outline selected specifications of the FED model and analyze its behavior during the financial crisis. We conclude that the reason for decrease in explanatory power stems from the change in economic fundamentals. The paper also explores theoretical drawbacks of the FED model.
    Keywords: Fed Model ; Fed Model ; Financial Crisis ; Finanční Krize ; Ocenění ; Valuation
    Source: Vysoká škola ekonomická (University of Economics, Prague)
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  • 10
    Language: English
    Source: Bentham Science Publishers
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