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  • 1
    Language: English
    In: The Journal of Urology, April 2016, Vol.195(4), pp.e119-e120
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.juro.2016.02.2391 Byline: Hendrik Borgmann Author Affiliation: Frankfurt, Germany Article Note: (footnote) Source of Funding: none
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
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  • 2
    Language: English
    In: The Journal of Urology, April 2016, Vol.195(4), pp.e812-e812
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.juro.2016.02.909 Byline: Hendrik Borgmann, Kush Dalal, Eliana Beraldi, Artem Cherkasov, Paul Rennie, Martin Gleave Author Affiliation: Vancouver, Canada Article Note: (footnote) Source of Funding: none
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
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  • 3
    Language: English
    In: The Journal of Urology, April 2018, Vol.199(4), pp.e484-e485
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
    Source: ScienceDirect Journals (Elsevier)
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  • 4
    Language: English
    In: The Journal of Urology, April 2016, Vol.195(4), pp.e119-e119
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.juro.2016.02.2390 Byline: Juan Gomez Rivas Author Affiliation: Madrid, Spain Article Note: (footnote) Source of Funding: none
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
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  • 5
    Language: English
    In: The Journal of Urology, September 2016, Vol.196(3), pp.664-671
    Description: Several nephrometry scores have been proposed to predict perioperative outcomes in renal surgery. We evaluated which nephrometry score correlates best with the MIC (margin, ischemia and complications) score and quantitative perioperative outcomes in nephron sparing surgery. Data on 188 patients undergoing nephron sparing surgery were retrospectively investigated for patient, operative and tumor characteristics. Nephrometry scores, including R.E.N.A.L. (radius, exophytic/endophytic properties, nearness of tumor to collecting system or sinus, anterior/posterior, hilar tumor touching the main renal artery or vein and location relative to polar lines), PADUA (preoperative aspects and dimensions used for an anatomical), C-index (concordance index) and DAP (diameter-axial-polar), were measured on preoperative computerized tomography or magnetic resonance imaging and coded continuously and categorically. Parameters pertaining to tumor margin, ischemia and complications were recorded as binary scores and classified as MIC achievement. Operative time, estimated blood loss, warm ischemia time and hospital stay were recorded as quantitative perioperative outcomes. The R.E.N.A.L. score correlated best with MIC and quantitative perioperative outcomes. The continuously coded R.E.N.A.L. score was predictive of MIC on univariate analysis (OR 0.75, 95% CI 0.58–0.97, p = 0.03) and it had the best predictive value on multivariate logistic regression analysis (OR 0.31, 95% CI 0.18–0.82, p = 0.03). The C-index but not the PADUA or the DAP score was predictive of MIC on univariate and multivariate logistic regression analysis. MIC achievement rates were significantly higher for low than for high complexity tumors as assessed by categorically coded R.E.N.A.L. score, C-index and DAP scores. Continuously coded R.E.N.A.L. and PADUA scores positively correlated with operative time, warm ischemia time and hospital stay. The C-index and the DAP score correlated with warm ischemia time. Of 4 nephrometry scores the R.E.N.A.L. score correlated best with MIC achievement and quantitative perioperative outcomes of nephron sparing surgery.
    Keywords: Kidney Neoplasms ; Ischemia ; Complications ; Prognosis ; Decision Support Techniques ; Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
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  • 6
    Language: English
    In: Canadian Urological Association Journal (CUAJ), Oct, 2015, Vol.9(10), p.E713
    Description: Introduction: Twitter use has grown exponentially within the urological community. We aimed to determine the perceptions of the impact of Twitter on users' clinical practice, research, and other professional activities. Methods: We performed an 11-item online survey of Twitter contributors during two major urological meetings: the European Association of Urology (EAU) and the American Urological Association (AUA) annual meetings. During the EAU 2014 meeting, we distributed the survey via the meeting official Twitter feed. During the AUA 2014 meeting, we applied a new method by directly sending the survey to Twitter contributors. We performed a subset analysis for assessing the perceived impact of Twitter on the clinical practice of physicians. Results: Among 312 total respondents, the greatest perceived benefits of Twitter among users were for networking (97%) and disseminating information (96%), followed by research (75%), advocacy (74%) and career development (62%). In total, 65% of Twitter users have dealt with guidelines on online medical professionalism and 71% of physician users found that Twitter had an impact on their clinical practice, and 33% had made a clinical decision based on an online case discussion. Conclusions: Our results suggest that Twitter users in the urological community perceive important benefits. These benefits extend to multiple professional domains, particularly networking, disseminating information, remote conference participation, research, and advocacy. This is the first study that has been disseminated to targeted individuals from the urological community directly through tweets, providing a proof of principle for this research method.
    Keywords: Career Development -- Analysis ; Social Media -- Analysis
    ISSN: 1911-6470
    Source: Cengage Learning, Inc.
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  • 7
    Language: English
    In: Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 2015, Vol.9(9-10), pp.E713-7
    Description: Twitter use has grown exponentially within the urological community. We aimed to determine the perceptions of the impact of Twitter on users' clinical practice, research, and other professional activities. We performed an 11-item online survey of Twitter contributors during two major urological meetings: the European Association of Urology (EAU) and the American Urological Association (AUA) annual meetings. During the EAU 2014 meeting, we distributed the survey via the meeting official Twitter feed. During the AUA 2014 meeting, we applied a new method by directly sending the survey to Twitter contributors. We performed a subset analysis for assessing the perceived impact of Twitter on the clinical practice of physicians. Among 312 total respondents, the greatest perceived benefits of Twitter among users were for networking (97%) and disseminating information (96%), followed by research (75%), advocacy (74%) and career development (62%). In total, 65% of Twitter users have dealt with guidelines on online medical professionalism and 71% of physician users found that Twitter had an impact on their clinical practice, and 33% had made a clinical decision based on an online case discussion. Our results suggest that Twitter users in the urological community perceive important benefits. These benefits extend to multiple professional domains, particularly networking, disseminating information, remote conference participation, research, and advocacy. This is the first study that has been disseminated to targeted individuals from the urological community directly through tweets, providing a proof of principle for this research method.
    Keywords: Career Development – Analysis ; Social Media – Analysis;
    ISSN: 1911-6470
    E-ISSN: 19201214
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  • 8
    Language: English
    In: Urology Practice, July, 2017, Vol.4(4), p.349
    Description: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.urpr.2016.07.011 Byline: Hendrik Borgmann [borgmann.hendrik@gmail.com] (a,*), Matthew S. Katz (b), James Catto (c), Christopher Weight (d), Alexander Kutikov (e) Key Words social support; social media; urology; blogging; health communication Abstract Introduction The social media microblogging service Twitter is gaining popularity in the field of urology as a fast and effective communication platform. We assessed volume, subject matter, influencers and content of urology related discussions on the Twitter platform using the recently proposed Urology Tag Ontology hashtag list. Methods We queried the Symplur Signals database for tweet activity during a 1-year period. We used the Urology Tag Ontology hashtag list, comprised of 45 disease related hashtags in 9 urological subspecialties, to assess activity (numbers of tweets, users and impressions), users (geolocation, influencers) and content (words, tweet enhancements) of urology related Twitter traffic. Results Twitter activity during the study period included 334,642 tweets by 104,166 users with 1,397,107,305 impressions. Tweet activity varied among urological subspecialties and was largely dominated by urological oncology topics driven by #ProstateCancer. Users came from 224 countries and from all continents around the globe. Health care organizations accounted for the largest proportion of influencers (44%), followed by other individuals (22%) and physicians (13%). The top words were "prevent" (used 20,955 times), "cancer" (19,610), "follow" (19,169), "men" (19,165) and "condom" (18,425). The median (range) number of shares was 2,200 (1,414-8,854) for the top 10 links, 2,123 (1,878-2,737) for the top 10 retweets and 207 (12-438) for the top 10 photos. Conclusions Twitter activity in the field of urology can be assessed using a standardized list of social media communication descriptors. The value of the Twitter communication platform is underscored by the large number of tweets and impressions in the urology space. Abbreviation and Acronym UTO, Urology Tag Ontology Author Affiliation: (a) Department of Urology, University Hospital Mainz, Mainz, Rheinland-Pfalz, Germany (b) Department of Radiation Medicine, Lowell General Hospital, Lowell, Massachusetts (c) Academic Urology Unit, University of Sheffield, Sheffield, United Kingdom (d) Department of Urology, University of Minnesota, Minneapolis, Minnesota (e) Division of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania * Correspondence: Department of Urology, University Hospital Mainz, Langenbeckstr. 1, 55131 Mainz, Germany (telephone: +49 176 61502875; FAX: +49 69 6301 81137). Article History: Accepted 12 April 2016 (footnote) No direct or indirect commercial incentive associated with publishing this article. (footnote) The corresponding author certifies that, when applicable, a statement(s) has been included in the manuscript documenting institutional review board, ethics committee or ethical review board study approval; principles of Helsinki Declaration were followed in lieu of formal ethics committee approval; institutional animal care and use committee approval; all human subjects provided written informed consent with guarantees of confidentiality; IRB approved protocol number; animal approved project number.
    Keywords: Social Support -- Analysis ; Urology -- Research
    ISSN: 2352-0779
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  • 9
    Language: English
    In: Cancer Research, 07/15/2016, Vol.76(14 Supplement), pp.4644-4644
    Description: The androgen receptor (AR) is a hormone inducible transcription factor that continues to be an important drug-target to prevent or slow the progression of prostate cancer. Current small molecule inhibitors, such as Enzalutamide (anti-androgens), compete with naturally occurring steroids that bind to the hormone binding pocket of the AR ligand binding domain (LBD). In advanced or castration resistant prostate cancer (CRPC), mutations in the LBD confer drug-resistance by converting anti-androgens into agonists, prompting research to develop small molecule inhibitors that target different sites on the AR protein surface. Recently, we characterized a set of small molecules that could interact with the DNA binding domain (DBD) of the AR and block its transcriptional activity. Here, we extend the pioneering observations by clarifying the mechanism of two classes of compounds that either block AR-chromatin interactions or reduce AR-dimerization in the cell nucleus. Compound efficacy is demonstrated across multiple prostate cancer cells lines, including enzalutamide resistant forms, with respect to AR transactivation, cell viability and expression of downstream genes. We also characterize the pharmacological properties of the lead compound and its effects on tumour xenografts in mice. Collectively, these results lay the foundation for the development of alternative prostate cancer drugs that interfere with the biochemical function of the activated, nuclear localized AR.
    Keywords: Drug Resistance ; Drug Development ; Steroid Hormones ; Hormones ; Castration ; Androgen Receptors ; Tumor Cell Lines ; Prostate Cancer ; Transcription Factors ; DNA ; Xenografts ; Nuclei ; Mutation ; Androgens ; Protein-Nucleic Acids Association;
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
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  • 10
    Language: English
    In: The Journal of Urology, April 2015, Vol.193(4), pp.e77-e77
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.juro.2015.02.278 Byline: Hendrik Borgmann, Jan-Henning Wolm, Michael Reiter, Kilian Gust, Stefan Vallo, Georg Bartsch, Roman Blaheta, Igor Tsaur, Axel Haferkamp Author Affiliation: Frankfurt, Germany Article Note: (footnote) Source of Funding: none
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
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