UID:
edoccha_9960161229202883
Format:
1 online resource (182 pages) :
,
illustrations, tables
Content:
Begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease.--
Note:
Preface -- History and modern view on DNA modifications in the brain / B.F. Vanyushin and V.V. Ashapkin -- Approaches to detecting DNA base modification in the brain / X. Li and W. Wei -- Active DNA demethylation in neurodevelopment / Y. Kang, Z. Wang and P. Jin -- TET and 5hmC in neurodevelopment and the adult brain / M. Fasolino, S.A. Welsh and Z. Zhou -- Beyond mCG : DNA methylation in noncanonical sequence context / E.A. Mukamel and R. Lister -- DNA modifications and memory / J.J. Day -- Measuring CpG methylation by SMRT sequencing / Y. Suzuki, J. Korlach and S. Morishita -- Epigenetic modifications of DNA and drug addiction / J. Feng and E.J. Nestler -- What does the future hold for the study of nucleic acid modifications in the brain? / P.R. Marshall and T.W. Bredy.
Additional Edition:
ISBN 0-12-801596-9
Additional Edition:
ISBN 0-12-801781-3
Language:
English
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