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Berlin Brandenburg

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  • 1
    Language: English
    In: Nature medicine, October 2018, Vol.24(10), pp.1492-1493
    Description: Acquired resistance to CD19-targeted CAR T cell therapy can occur through mutations in the CD19 gene or after insertion of a chimeric antigen receptor (CAR) into leukemia cells, resulting in the adjacent receptor being masked by the CAR.
    Keywords: Immunotherapy – Complications and Side Effects ; Membrane Proteins – Health Aspects ; Tumors – Care and Treatment ; Tumors – Development and Progression ; T Cell Antigen Receptors – Health Aspects ; Leukemia – Care and Treatment;
    ISSN: 10788956
    E-ISSN: 1546-170X
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  • 2
    Language: English
    In: Clinical Cancer Research, 01/01/2016, Vol.22(1 Supplement), pp.IA20-IA20
    ISSN: 1078-0432
    E-ISSN: 1557-3265
    Source: CrossRef
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  • 3
    Language: English
    In: Clinical advances in hematology & oncology : H&O, January 2016, Vol.14(1), pp.17-9
    Keywords: Recombinant Fusion Proteins ; Antibodies, Monoclonal -- Genetics ; Receptors, Antigen, T-Cell -- Genetics ; T-Lymphocytes -- Immunology
    ISSN: 1543-0790
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 4
    Language: English
    In: Blood, 26 April 2012, Vol.119(17), pp.3872-3
    Description: In this issue of Blood, Till et al present 3 patients with relapsed B-cell lymphomas treated with autologous T cells genetically modified to express a CD20-targeted chimeric antigen receptor (CAR) demonstrating both safety and clinical efficacy.
    Keywords: Medicine ; Biology ; Chemistry ; Anatomy & Physiology;
    ISSN: 00064971
    E-ISSN: 1528-0020
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  • 5
    In: Clinical Infectious Diseases, 2018, Vol. 67(4), pp.533-540
    Description: Cytokine release syndrome grade 3 or higher was independently associated with increased risk of subsequent infection and in particular with bloodstream infection in patients with relapsed B-cell acute lymphoblastic leukemia treated with CD19 chimeric antigen receptor T-cell therapy.
    Keywords: Cytokine Release Syndrome ; Car T - Cell Therapy ; Relapsed Acute Lymphoblastic Leukemia ; Early Infections ; Late Infections
    ISSN: 1058-4838
    E-ISSN: 1537-6591
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  • 6
    Language: English
    In: Stem cells and development, 01 July 2013, Vol.22(13), pp.1861-9
    Description: Human embryonic stem cell (hESC)-derived natural killer (NK) cells are a promising source of antitumor lymphocytes for immunotherapeutics. They also provide a genetically tractable platform well suited for the study of antitumor immunotherapies in preclinical models. We have previously demonstrated the potency of hESC-derived NK cells in vivo. Here we use both bioluminescent and fluorescent imaging to demonstrate trafficking of hESC-derived NK cells to tumors in vivo. Our dual-imaging approach allowed us to more specifically define the kinetics of NK cell trafficking to tumor sites. NK cell persistence and trafficking were further evaluated by flow cytometry and immunohistochemistry. This integrated approach provides a unique system to apply the use of human pluripotent stem cells to study the kinetics and biodistribution of adoptively transferred lymphocytes, advances broadly applicable to the field of immunotherapy.
    Keywords: Cell Differentiation ; Embryonic Stem Cells -- Metabolism ; Killer Cells, Natural -- Metabolism ; Lymphocytes -- Metabolism ; Neoplasms -- Therapy
    ISSN: 15473287
    E-ISSN: 1557-8534
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  • 7
    Language: English
    In: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 20 May 2015, Vol.33(15), pp.1703-6
    Keywords: Bone Neoplasms -- Therapy ; Immunotherapy -- Methods ; Receptor, Erbb-2 -- Metabolism ; Sarcoma -- Therapy ; T-Lymphocytes -- Immunology
    ISSN: 0732183X
    E-ISSN: 1527-7755
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  • 8
    Language: English
    In: Expert Review of Hematology, 02 June 2016, Vol.9(6), pp.511-513
    Keywords: Car T Cell ; Chimeric Antigen Receptor ; Cytokine Release Syndrome ; Immunotherapy ; Cd19
    ISSN: 1747-4086
    E-ISSN: 1747-4094
    Source: Taylor & Francis (Taylor & Francis Group)
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  • 9
    Language: English
    In: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 20 February 2015, Vol.33(6), pp.651-3
    Keywords: Antigens, Cd19 -- Immunology ; Antineoplastic Combined Chemotherapy Protocols -- Therapeutic Use ; Immunotherapy, Adoptive -- Methods ; Lymphoma, B-Cell -- Therapy ; Lymphoma, Large B-Cell, Diffuse -- Therapy ; Receptors, Antigen, T-Cell -- Immunology ; T-Lymphocytes -- Transplantation
    ISSN: 0732183X
    E-ISSN: 1527-7755
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  • 10
    Language: English
    In: Cancer Research, 04/15/2010, Vol.70(8 Supplement), pp.1940-1940
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
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