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  • 1
    Language: English
    In: BJU international, August 2013, Vol.112(4), pp.E383-90
    Description: What's known on the subject? and what does the study add?: Only little and partly contradictory data are currently published about the prognostic role of immunohistochemically detectable proliferation-associated biomarkers in surgically treated squamous cell carcinoma of the penis (SCCP), and no data are available at present about their usefulness for refining the delineation between different Broders' grading categories (e.g. still G2 or just G3 SCCP?). Moreover, the accuracy of various conventional histopathological parameters for predicting cancer-specific survival (CSS) in surgically treated SCCP has not been systematically evaluated yet. Based on the so far largest study cohort encompassing 158 consecutive patients with surgically treated PSCCs characterised by means of a central histopathological review, our data add the following to the currently available literature: (i) Ki-67, mini-chromosome maintenance 2 protein (MCM2), and geminin indicate a more aggressive behaviour in SCPP but do not represent independent prognostic parameters in the multivariable analysis in terms of CSS, (ii) these three biomarkers are not helpful for refining the delineation between different Broders' grading categories at the immunohistochemical level, and (iii) the conventional histopathological parameters staging, grading, nodal involvement, and lymphovascular invasion are independent prognostic parameters that together achieve a predictive accuracy of 82% for CSS. To assess the role of cell proliferation-associated biomarkers to predict cancer-specific survival (CSS) in patients with surgically treated squamous cell carcinoma of the penis (SCCP). A multicentre study enrolling 158 consecutive patients with surgically treated SCCP was performed. After conducting a central histopathological review, the staining profiles of Ki-67, mini-chromosome maintenance 2 protein (MCM2) and geminin were evaluated for their correlation with conventional histopathological criteria and their prognostic relevance for predicting CSS in a multivariable Cox proportional hazards regression model (median [interquartile range] follow-up 33 [6-63] months). Staining evaluation showed high interobserver agreement (92-96%). Ki-67 and MCM2 displayed a significant positive correlation with histological tumour grade, lymphovascular invasion (LVI) and nodal status, whereas geminin expression only correlated with tumour grade. The 5-year CSS for the entire study cohort was 62%. Univariable analysis showed a significant prognostic impact of Ki-67 (P = 0.026), MCM2 (P = 0.007), and geminin (P = 0.036). In multivariable analysis, only pT (hazard ratio [HR] 1.67; P = 0.003) and pN stage (HR 2.62; P = 0.015) as well as tumour grade (HR 1.89; P = 0.036) and LVI (HR 2.66; P = 0.028) were identified as independent prognostic parameters for CSS. The accuracy of the Cox model for CSS prediction was 0.820 (95% confidence interval 0.741-0.898). At present, conventional histopathological criteria remain the most powerful predictors of CSS in surgically treated SCCP. Due to overlapping staining profiles, Ki-67, MCM2 and geminin, either singly or in various combinations, failed to immunohistochemically refine the boundaries between Broders' grading categories. Ki-67, MCM2 and geminin do not represent independent prognostic parameters but reflect a more aggressive behaviour in surgically treated SCCP. Further studies are needed to clarify the currently contradictory predictive role of proliferation-associated biomarkers in terms of predicting nodal involvement in SCCPs.
    Keywords: Ki-67 ; Geminin ; Immunohistochemistry ; Mini-Chromosome Maintenance 2 Protein (Mcm2) ; Proliferation-Related Biomarkers ; Squamous Cell Carcinoma of the Penis (Sccp) ; Carcinoma, Squamous Cell -- Chemistry ; Cell Cycle Proteins -- Analysis ; Ki-67 Antigen -- Analysis ; Nuclear Proteins -- Analysis ; Penile Neoplasms -- Chemistry
    ISSN: 14644096
    E-ISSN: 1464-410X
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  • 2
    In: Cancer, 15 November 2014, Vol.120(22), pp.3584-3584
    Keywords: Cystectomy ; Neoplasm Recurrence, Local -- Etiology ; Urinary Bladder Neoplasms -- Surgery;
    ISSN: 0008-543X
    E-ISSN: 1097-0142
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  • 3
    In: BJU International, June 2013, Vol.111(7), pp.1015-1017
    Description: Byline: Sabine Brookman-May, Martin Marszalek, Steven Joniau, Andrea Minervini, Johan F. Langenhujisen, Vincenzo Ficarra, Maciej Salagierski, Marco Roscigno, Bulent Akdogan, Alkuin Vandromme, Oscar Rodriguez-Faba, Alessandro Volpe, ***** No abstract is available for this article. ***** Author Affiliation:
    Keywords: Medical Research -- Health Aspects ; Cancer Treatment -- Health Aspects;
    ISSN: 1464-4096
    E-ISSN: 1464-410X
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  • 4
    In: BJU International, May 2013, Vol.111(5), pp.692-694
    Description: Byline: Sabine Brookman-May, Andrea Minervini, Alessandro Volpe, Vincenzo Ficarra, Maciej Salagierski, Martin Marszalek, Marco Roscigno, Bulent Akdogan, Alkuin Vandromme, Hans Langenhuijsen, Oscar Rodriguez-Faba, Steven Joniau, ***** No abstract is available for this article. ***** Author Affiliation:
    Keywords: Recurrence (Disease) -- Care And Treatment ; Robots ; Robotics Industry ; Robotic Surgery;
    ISSN: 1464-4096
    E-ISSN: 1464-410X
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  • 5
    In: BJU International, October 2012, Vol.110(8b), pp.E350-E356
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/j.1464-410X.2012.11087.x/abstract Byline: Oleg Rud(1), Johannes Moersler(2), Julia Peter(1), Przemyslaw Waliszewski(1)(3), Christian Gilfrich(1), Hannes Hauser(2), Maximilian Burger(4), Hans-Martin Fritsche(4), Wolf F. Wieland(4), Ali M. Ahmed(1), Sabine Brookman-May(4), Matthias May(1) Keywords: acute hydronephrosis; acute renal colic; hydronephrosis index; interobserver variability; renal resistive index; urolithiasis Study Type - Diagnosis (reliability) Level of Evidence 2b What's known on the subject? and What does the study add? Conventional sonography is the standard imaging technique used in patients with acute renal colic. A decreasing hydronephrosis index (HI) is associated with an increase in obstructive uropathy. Obstructive uropathy leads to an increase in the renal resistive index (RRI). The present study shows that both the RRI and HI methods are easily practicable in patients presenting with stone-related renal colic. The grade of hydronephrosis correlates positively with the HI but not with the RI. OBJECTIVE To confirm the reliability of assessements of the renal resistive index (RRI) and the hydronephrosis index (HI) comprising two sonographic techniques providing additional information in patients with acute renal colic. PATIENTS AND METHODS Sonographic measurement of hydronephrosis and assessment of common clinical criteria was performed in 22 consecutive patients presenting with unilateral stone-related renal colic. RRI and HI were separately recorded by two investigators within a prospective study. Interobserver agreement and comparison of sonographic with computed tomography (CT) findings were assessed with the Cohen's kappa statistic (I*) for attributive ordinal characteristics and Spearman's rank correlation/rho (I) for attributive metric characteristics. RESULTS There was a significant correlation between HI and the sonographically-evaluated grade of hydronephrosis, although not between RRI and the grade of hydronephrosis. For all procedures (RRI, HI, sonography and CT), significant differences between the symptomatic and the asymptomatic kidney were assessed. Interobserver agreement was excellent for the grade assessment of hydronephrosis by conventional sonography (I*= 0.82; P 0.001), good to very good for HI (I= 0.60; P= 0.003) and acceptable to good for RRI (I= 0.49; P= 0.021). CONCLUSIONS The RRI and HI methods are both easily practicable as stageless examination methods in patients presenting with stone-related renal colic, and both also reliably distinguish between obstruction and non-obstruction. Exact thresholds for both methods must still be defined based on further successive studies. Additionally, changes of values under medical expulsive therapy and correlation with the functional status of the obstructed kidney remain to be examined. Author Affiliation: (1)Department of Urology (2)Institute of Radiology, St Elisabeth-Hospital, Straubing (3)Department of Urology, Philipps-University Marburg, Marburg (4)Department of Urology, Caritas-Hospital St Josef, University Regensburg, Regensburg, Germany Correspondence: (*) Oleg Rud, Department of Urology, St Elisabeth Klinikum Straubing, St Elisabeth Street 23, 94315 Straubing, Germany. e-mail: oleg.rud@klinikum-straubing.de Accepted for publication 10 November 2011
    Keywords: Acute Hydronephrosis ; Acute Renal Colic ; Hydronephrosis Index ; Interobserver Variability ; Renal Resistive Index ; Urolithiasis
    ISSN: 1464-4096
    E-ISSN: 1464-410X
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  • 6
    In: BJU International, November 2013, Vol.112(7), pp.909-916
    Description: Byline: Sabine D. Brookman-May, Matthias May, Shahrokh F. Shariat, Giacomo Novara, Richard Zigeuner, Luca Cindolo, Ottavio De Cobelli, Cosimo De Nunzio, Sascha Pahernik, Manfred P. Wirth, Nicola Longo, Alchiede Simonato, Sergio Serni, Salvatore Siracusano, Alessandro Volpe, Giuseppe Morgia, Roberto Bertini, Orietta Dalpiaz, Christian Stief, Vincenzo Ficarra, Keywords: renal cell carcinoma (RCC); time to recurrence; early recurrence; late recurrence; prognostic parameters; cancer-specific survival; nephrectomy Objectives * To assess the prognostic impact of time to recurrence (TTR) on cancer-specific survival (CSS) after recurrence in patients with renal cell carcinoma (RCC) undergoing radical nephrectomy or nephron-sparing surgery. * To analyse differences in clinical and histopathological criteria between patients with early and late recurrence. Patients and Methods * Of 13107 patients with RCC from an international multicentre database, 1712 patients developed recurrence in the follow-up (FU), at a median (interquartile range) of 50.1 (25-106) months. * In all, 1402 patients had recurrence at [less than or equal to]5 years (Group A) and 310 patients beyond this time (Group B). * Differences in clinical and histopathological variables between patients with early and late recurrence were analysed. * The influence of TTR and further variables on CSS after recurrence was assessed by Cox regression analysis. Results * Male gender, advanced age, tumour diameter and stage, Fuhrman grade 3-4, lymphovascular invasion (LVI), and pN + stage were significantly more frequent in patients with early recurrence, who had a significantly reduced 3-year CSS of 30% compared with patients in Group B (41%; P = 0.001). * Age, gender, tumour histology, pT stage, and continuous TTR (hazard ratio 0.99, P = 0.006; monthly interval) independently predicted CSS. * By inclusion of dichotomised TTR in the multivariable model, a significant influence of this variable on CSS was present until 48 months after surgery, but not beyond this time. Conclusions * Advanced age, male gender, larger tumour diameters, LVI, Fuhrman grade 3-4, pN + stage, and advanced tumour stages are associated with early recurrence. * Up to 4 years from surgery, a shorter TTR independently predicts a reduced CSS after recurrence. Article Note: S.D.B.-M. and M.M contributed equally to this manuscript Supporting information: Additional Supporting Information may be found in the online version of this article CAPTION(S): Fig.S1 OS after disease recurrence by risk stratification related to TTR ([less than or equal to]12, 〉12-60, 〉60 months). Fig.S2 OS after disease recurrence by risk stratification related to TTR ([less than or equal to]12, 〉12-48, 〉48 months).
    Keywords: Renal Cell Carcinoma ; Time To Recurrence ; Early Recurrence ; Late Recurrence ; Prognostic Parameters ; Cancer‐Specific Survival ; Nephrectomy
    ISSN: 1464-4096
    E-ISSN: 1464-410X
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  • 7
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  • 9
    Language: English
    In: Urology, April 2016, Vol.90, pp.9-15
    Description: Focal cryoablation is an established minimally invasive technique for the treatment of small renal masses. Because of the lack of robust evidence, it is indicated in selected patients who have relative contraindications to extirpative approaches. With appropriate selection of patients, cryoablation is safe and effective. Main advantages are low risk for complication, minimal invasiveness, and good functional outcomes; oncological outcomes require further studies. The role of the percutaneous approach has been expanding because of its ability to reduce pain and hospitalization, the possibility of performing the procedure under sedation, and the fact that it is potentially more cost effective.
    Keywords: Medicine
    ISSN: 0090-4295
    E-ISSN: 1527-9995
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  • 10
    Language: English
    In: Expert Review of Vaccines, 01 June 2011, Vol.10(6), pp.837-852
    Description: As renal cell carcinoma represents one of the most immune-responsive cancers, immunotherapy exhibits a suitable treatment basis. Beside nonspecific stimulation via cytokines, passive specific and active immunotherapy are also appropriate options to recognize and destroy tumor cells. For more than 30 years, research regarding vaccination therapy has been of special interest for the treatment of renal cell carcinoma. However, apart from occasional promising results in Phase I and II trials, vaccination therapy is still considered experimental in this tumor entity, especially owing to missing results from Phase III trials demonstrating clinical efficacy. In the present article, we review data from completed clinical trials of vaccination therapy and also discuss scheduled future trials, in order to assess the current position and possible future fields of application of vaccination therapy in renal cell carcinoma in the era of recently developed targeted therapies.
    Keywords: Autologous Tumor Cell Vaccine ; Dendritic Cell-Based Vaccine ; Genetically Modified Vaccine ; Immunomodulation ; Peptide-Based Vaccine ; Renal Cell Carcinoma ; Vaccination Therapy ; Biology
    ISSN: 1476-0584
    E-ISSN: 1744-8395
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