Brain Research, Jan 12, 2011, Vol.1368, p.271(10)
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.brainres.2010.10.055 Byline: Starlee Lively, Ian R. Brown Keywords: Status epilepticus; Heat shock protein; Cerebral cortex; Astrocyte; Neuron Abbreviations: GFAP, glial fibrillary acidic protein; HO-1, heme oxygenase-1; Hsc, heat shock cognate protein; Hsp, heat shock protein; IB4, GSA-isolectin B4; IL-1[beta], interleukin-1 beta; PBS, phosphate buffered saline; SE, status epilepticus; TNF[alpha], tumor necrosis factor alpha Abstract: The expression pattern of a global set of Hsps in the adult rat cerebral cortex was examined during the first week following pilocarpine-induced status epilepticus (SE). Hsp70 and Hsp32 protein were induced at 1day post-SE and decreased thereafter, whereas Hsp25 exhibited a prolonged induction with increased levels at 3 and 7days post-SE. Hsp70 was induced in neurons, while Hsp25 and Hsp32 localized to GFAP-positive hypertrophied astrocytes. The induction of Hsp25, Hsp32 and Hsp70 at 1day following SE suggests the involvement of these Hsps in early events after SE. Interestingly, while Hsp32 and Hsp70 expression was transient, Hsp25 demonstrated a sustained induction pattern, which may reflect an additional role of Hsp25 in subsequent remodeling events in the days following SE. Article History: Accepted 14 October 2010
Heme ; Status Epilepticus ; Heat Shock Proteins ; Intermediate Filament Proteins ; Phosphates ; Brain
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