Kooperativer Bibliotheksverbund

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Format: X, 76 S. : graph. Darst.

ISBN: 3-540-52597-1 , 0-387-52597-1

Note: Literaturangaben

Language: German

Keywords: Diabetes mellitus ; Therapie ; Angiopathia diabetica ; Prävention ; Angiopathia diabetica ; Prävention ; Aufsatzsammlung

Author information: Dreyer, Manfred

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Format: XII, 317 S. : , Ill.

ISBN: 978-981-270-648-5 , 981-270-648-8

Language: English

URL: Inhaltsverzeichnis

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Format: xviii, 249 p. : , ill. (some col.).

Edition: Electronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries.

Language: English

Keywords: Electronic books.

URL: Click to View

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Format: viii, 390 p. : , ill. (some col.)

Edition: Electronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries.

Language: English

Keywords: Electronic books.

URL: Click to View

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Format: xvii, 316 p. : , ill.

Edition: Electronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries.

Language: English

Keywords: Electronic books.

URL: Click to View

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Format: 1 online resource (399 p.)

Edition: 1st ed.

ISBN: 1-283-59367-X , 9786613906120 , 981-4335-36-3

Content: The role of the cytokine, macrophage migration inhibitory factor (MIF), in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well established. The aim of this handbook is to provide an authoritative volume covering all aspects of MIF, from basic molecular biology to structure-function relationships, pathophysiology, genetics, and drug development.Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, cardiac physiology, and

Note: Description based upon print version of record. , Contents; Preface; Part I MIF Structure and Mechanism of Action; I-1 MIF, MIF Alleles, and the Regulation of the Host Response Richard Bucala; 1. Introduction; 2. MIF Gene; 3. MIF Production and Signal Transduction; 4. Innate Immunity; 5. Adaptive Immunity; 6. MIF Integrates Immune, Metabolic, and Oncogenic Responses; 7. MIF Alleles in Human Disease; 8. Therapeutic Implications and Future Directions; Acknowledgments; References; I-2 MIF and the Chemokine Axis Sandra Kraemer, Christian Weber and Jürgen Bernhagen; 1. Introduction; 2. Chemokines: Classes, Structure, Function, and Receptors , 3. Structural Classification of MIF4. Nonclassical MIF Secretion and Link to Secretion of CLF Chemokines; 5. Chemokine-like Function (CLF) Chemokines and MIF as a CLF Chemokine; 6. MIF/ Chemokine Receptor Interactions and Functional Role in Inflammation and Atherogenesis; 7. Structural Basis Underlying MIF/Chemokine Receptor Interactions; 8. MIF Receptor Complexes; 9. Conclusion; 10. Acknowledgments; References; I-3 CD74, the Natural Receptor for MIF, Regulates Cell Survival in Health and Disease Idit Shachar, Maya Gordin, Sivan Cohen, Inbal Binsky, Ayelet Marom and Shirly Becker-Herman , 1. Introduction2. CD74 (Invariant Chain, Ii); 3. CD74 Functions as a Chaperone for MHC Class II; 4. CD74 as a Signaling Molecule; 4.1 CD74 is a cell surface receptor that induces signaling cascades; 4.2 CD74 is subjected to regulated intramembrane proteolysis (RIP); 5. MIF Regulates B Cell Survival in a CD74-Dependent Manner; 5.1 A complex of CD74 and CD44 is essential for initiating the signaling cascade induced by MIF; 5.2 c-Met and its ligand HGF regulate mature B cell survival in a pathway induced by MIF binding to CD74/CD44 , 5.3 MIF induces TAp63 expression, which regulates B cell survival in a CD74-dependent manner6. MIF Is Secreted from Perivascular Bone Marrow Dendritic Cell Clusters that Regulate B Cell Survival; 7. MIF and CD74 in Tumors; 7.1 MIF and CD74 in CLL survival; 7.2 MIF and CD74 regulate CLL homing to the BM; References; I-4 Towards the MIF Interactome Jörg Klug and Andreas Meinhardt; 1. Introduction; 2. MIF Affects Degradation of Regulatory Proteins by Modulating the Ubiquitin Proteasome System; 3. Ribosomal Protein S19 as Endogenous Inhibitor of Extracellular MIF , 4. Interactors Involved in MIF Redox Activity4.1. Insulin; 4.2. Hepatopoietin (HPO); 4.3. Proliferation-associated gene (PAG) protein; 4.4. p53; 4.5. Protein (NM23A) expressed in nonmetastatic cells (NM23-H1); 4.6. α1-inhibitor-3 (α1-I3); 5 Concluding Remarks; Acknowledgments; References; I-5 Structural Studies of Small Molecule Inhibitors of MIF Yoonsang Cho and Elias J. Lolis; 1. Introduction; 2. Small Molecule Structures; 3. Catalytic Site Inhibitors; 4. Covalent Inhibitors; 5. Allosteric and Mixed Inhibitors; References; Part II Regulation of MIF Expression , II-1 Epigenetic Control of MIF Expression Thierry Roger, Jérôme Lugrin, Xavier C. Ding and Thierry Calandra , English

Additional Edition: ISBN 981-4335-35-5

Language: English

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Format: 1 online resource (335 p.)

Edition: 1st ed.

ISBN: 1-280-66943-8 , 9786613646361 , 981-4343-72-2

Content: This volume provides a comprehensive and multidisciplinary overview of fibrocytes, written by the main researchers in the field. It is aimed at a broad audience of scientists and clinicians with an interest in the role of circulating fibrocytes in the etiopathogenesis of different fibrosing disorders, atherosclerosis, autoimmunity, and cancer.

Note: Description based upon print version of record. , Contents; Preface; Contributors; Chapter 1. Hematopoietic Origin of Fibrocytes Mehrdad Abedi; 1.1. Introduction; 1.2. Structure of Bone Marrow; 1.3. Marrow-Derived Fibroblasts; 1.4. Origin of Fibroblasts in Tissue; 1.5. Fibrocytes; 1.6. What is the Relation between Macrophages and Circulating Fibroblasts Precursors?; 1.7. Perspective; References; Chapter 2. Fibrocytes and Collagen-Producing Cells of the Peripheral Blood Richard H. Gomer and Darrell Pilling; 2.1. Introduction: Fibrocytes Precursors Originate in Bone Marrow, and Exist in Blood , 2.2. The Chemokine CXCL12 Attracts Circulating Fibrocyte Precursors to Sites of Injury2.3. Identification of Circulating CCPCs in the Blood; 2.4. Pulmonary Fibrosis Patients have Abnormally High Numbers of CCPCs; 2.5. Scleroderma Patients have Abnormally High Numbers of CCPCs; 2.6. Differences between CCPCs from Scleroderma Patients and Controls; 2.7. Patients with Chronic Asthma have Abnormally High Numbers of CCPCs; 2.8. CCPCs in Rheumatoid Arthritis Patients; 2.9. The Number of CCPCs Increases with Age; 2.10. The Number of CCPCs Increases in an Animal Injury Model , 2.11. Summary and Future DirectionsAcknowledgements; References; Chapter 3. Regulatory Pathways of Fibrocyte Development Darrell Pilling and Richard H. Gomer; 3.1. Introduction; 3.2. Inhibition of Initial Fibrocyte Differentiation by Fcγ Receptor Ligation; 3.3. Inhibition of Initial Fibrocyte Differentiation by Cytokines; 3.4. Profibrotic Cytokines Promote Fibrocyte Differentiation; 3.5. Regulation of Mature Fibrocyte Differentiation; References; Chapter 4. Fibrocyte Differentiation Pathways Ellen C. Keeley, Borna Mehrad and Robert M. Strieter; 4.1. Introduction , 4.2. Fibrocyte Differentiation along Mesenchymal Lineages4.2.1. Myofibroblasts; 4.2.2. Adipocytes; 4.2.3. Osteoblasts and Chondrocytes; 4.3. Fibrocytes can be Reprogrammed to Modify the Fibroproliferative Response; 4.4. Factors that Influence Differentiation of Fibrocytes from their Precursors; 4.5. Conclusion; References; Chapter 5. Immunoregulation of Fibrocyte Differentiation Matthias Mack, Marianne Niedermeier and Barbara Reich; 5.1. Detection and Origin of Fibrocytes; 5.2. Interaction of Monocytes with CD4+ T Cells Enables Differentiation of Fibrocytes , 5.3. Cytokines and CD4+ T Cell Phenotypes Regulate Fibrocyte Differentiation5.4. Influence of Serum on Fibrocyte Differentiation; 5.5. Proliferation of Fibrocytes?; 5.6. Migration of Fibrocytes; 5.7. How Fibrocytes Affect CD4+ T Cells; 5.8. Conclusion; References; Chapter 6. The Role of Fibrocytes in Wound Repair and Hypertrophic Scarring Abelardo Medina, Jie Ding, Moein Momtazi, and Edward E. Tredget; 6.1. Introduction; 6.2. Dysregulated Repair of the Extracellular Matrix of Hypertrophic Scars; 6.3. Dysregulated Apoptosis in Hypertrophic Scar , 6.4. Increased Levels of the Profibrotic Growth Factors TGF-β and CTGF in Hypertrophic Scarring , English

Additional Edition: ISBN 981-4343-71-4

Language: English

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Format: 1 online resource (236 p.)

ISBN: 981-4405-58-2

Content: Malaria is one of the most important "emerging" or "resurgent" infectious diseases. According to the World Health Organization, this mosquito-borne infection is a leading cause of suffering, death, poverty, and underdevelopment in the world today. Every year 500 million people become severely ill from malaria and more than a million people die, the great majority of them women and children living in sub-Saharan Africa. In 2008, it was estimated, a child would die of the disease every thirty seconds, making malaria - together with HIV/AIDS and tuberculosis - a global public health emergency. Th

Note: Includes index. , Contents; Introduction; Acknowledgements; Contributors; Part I Lessons of History; Chapter 1 Malaria in America; Introduction; The Parasites and Their Vectors; Immigrants to the New World and the Arrival of Malaria; Fighting Back; World War II and New Tools for the Malaria Wars; Lessons Learned; Chapter 2 Technological Solutions: The Rockefeller Insecticidal Approach to Malaria Control, 1920-1950; Chapter 3 Malaria Control and Eradication Projects in Tropical Africa, 1945-1965; Introduction; A Basis For Optimism, I - Malaria Control Outside of Tropical Africa , A Basis for Optimism, II - Malaria Control in Africa Before and Immediately After WWIIThe Transfer of Synthetic Insecticide, 1945-1950; The First African Malaria Conference: Kampala, 1950; The WHO Project Sites; The Entomological Labyrinth; The Mixed Record of Synthetic Insecticides; The Loss of Acquired Immunities and Epidemic 'Rebound' Malaria; Antimalarial Drugs and the Pilot Projects; The Lessons of the Malaria Control and Eradication Projects; Chapter 4 The Use and Misuse of History: Lessons from Sardinia; Introduction; Malaria and Sardinia as Synonyms , The First Campaign against Malaria: Before DDTThe Crisis after World War II; The Second Campaign against Malaria: ERLAAS and DDT; Additional Factors in Eradication; Conclusion; Chapter 5 Popular Education and Participation in Malaria Control: A Historical Overview; Introduction; Italian PEP Experience; Early Rockefeller Foundation Enthusiasm Concerning Popular Education; IHB's New Orientation Under New Leadership; Neglect of Italian Experience by Foundation's Malarialogists; Post-WWII Developments; PEP in the post-Eradication period (1970-1990); The modern era (1990-today) , Concluding CommentsPart II Scientific, Medical, and Public Health Perspectives; Chapter 6 The Contribution of The Gambia to Malaria Research; The Gambia; Malaria in The Gambia in the Pre-colonial Period; Malaria in Colonial Times; The 1902 Expedition to The Gambia; The Medical Research Council (MRC) Unit, The Gambia; The MRC laboratories; Malaria entomology; Immunity to malaria; Pathogenesis of malaria; Treatment of malaria; Chemoprophylaxis; Vector control; Malaria vaccines; Malaria in The Gambia in 2012; Conclusion; Acknowledgements , Chapter 7 Insecticide-Treated Bednets and Malaria Control: Strategies, Implementation, and OutcomeOverview; Parasite and Vector Biology; Bednets: A Historical Perspective; Bednet Materials and Design; Netting materials; Net design; Insecticides; Retreatment of ITNs; Long-lasting insecticidal nets; Other insecticide-treated materials; Efficacy of untreated bednets; Efficacy of ITNs and LLINs; Experimental hut trials; Field trials; Field Trials: All-cause childhood mortality; Field Trials: Malaria morbidity; ITNs and malaria in pregnancy; Community effect; LLINs; ITN Efficacy: Conclusions , Insecticide Resistance , English

Additional Edition: ISBN 981-4405-57-4

Additional Edition: ISBN 1-306-56617-7

Language: English

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Format: 1 online resource (332 p.)

ISBN: 1-281-92895-X , 9786611928957 , 981-277-591-9

Content: In recent years, researchers have identified a pivotal, upstream role for macrophage migration inhibitory factor (MIF) in the innate immune response. This pioneering book describes this renaissance of knowledge in the biology of MIF. Topics covered include MIF's molecular mechanism of action, its counterregulatory action on the immunosuppressive properties of glucocorticoids, its role in the production of proinflammatory mediators as shown in cell-based and animal studies; and its central role in human inflammation. Human genetic studies have identified allelic forms of the MIF gene, and high-

Note: Description based upon print version of record. , Historical overview / R. David -- MIF "rediscovered" / R. Bucala -- Immunopathologic mechanisms relevant to diseases / H.Y. Lan -- Structural studies of MIF / E. Lolis -- MIF redox activity / J. Bernhgaen -- MIF receptor-mediated signal transduction / C. Leng -- MIF in innate immunity and infectious diseases / T. Calandra -- MIF in parasitic and helminth infections / A.R. Satoskar -- MIF in the pathogenesis of kidney disease / R.C. Atkins -- MIF and CNS autoimmune disease / T.G. Forsthuber -- MIF: wound repair / G.S. Ashcroft -- MIF and atherosclerosis / C. Weber -- Inflammatory arthritis / E. Morand -- MIF alleles in infammatory arthritis / R. Donn -- Adhesion-dependent signaling and growth control / R. Mitchell. , English

Additional Edition: ISBN 981-270-648-8

Language: English

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Format: 1 online resource (268 p.)

Edition: 1st ed.

ISBN: 1-281-12089-8 , 9786611120894 , 981-270-669-0

Content: Since the discovery of the circulating "fibrocyte" in 1994 as a collagen-producing cell of the peripheral blood, the physiologic and pathologic role of this unique cell populaton has grown steadily. This pioneering new book provides the first comprehensive review of the role of fibrocytes in wound repair, granuloma formation, antigen presentation, scar formation, and various fibrosing disorders such as interstitial lung disease and nephrogenic systemic fibrosis. It also includes discussions of the recent studies on the molecular signals that influence fibrocyte migration, proliferation, and fu

Note: Description based upon print version of record. , Contributors; CONTENTS; Chapter 1 Fibrocytes: Discovery of a Circulating Connective Tissue Cell Progenitor Richard Bucala; Chapter 2 Fibrocytes: Immunologic Features Jason Chesney; Chapter 3 Regulatory Pathways for Fibrocyte Differentiation Darrell Pilling and Richard H. Gomer; Chapter 4 Hematopoietic Origin of Fibrocytes Amanda C. LaRue and Makio Ogawa; Chapter 5 The Role of Fibrocytes in Post-burn Hypertrophic Scarring JianFei Wang, Yaujiong Wu, Abelardo Medina, Paul. G. Scott and Edward E. Tredget; Chapter 6 Role in Asthmatic Lung Disease Sabrina Mattoli and Matthias Schmidt , Chapter 7 Fibrocytes and Other Fibroblast/Myofibroblast Progenitors in Systemic Sclerosis Arnold E. PostlethwaiteChapter 8 Fibrocytes in Interstitial Lung Disease Brigitte N. Gomperts and Robert M. Strieter; Chapter 9 Role of Fibrocytes in Renal Fibrosis Norihiko Sakai, Takashi Wada, Kouji Matsushima and Shuichi Kaneko; Chapter 10 Role of Fibrocytes in Atherogenesis Heather Medbury; Chapter 11 Nephrogenic Systemic Fibrosis: A Prototype Fibrocyte Disease Cynthia L. Kucher and Shawn E. Cowper; Chapter 12 CD34+ Fibrocytes in Normal and Neoplastic Human Tissues Peter J Barth; Index , English

Additional Edition: ISBN 981-256-869-7

Language: English