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Berlin Brandenburg

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  • 1
    In: Journal of Bacteriology, Nov, 1995, Vol.177(21-22), p.6390(11)
    Description: A physical map representing the chromosome of Neisseria meningitidis Z2491 is presented. Probes corresponding to single-copy genes or sequences are utilized on Southern blots of chromosomal DNA digested with the various mapping enzymes and exposed to CHEF electrophoresis. Comparison of gene locations with that of the Neisseria gonorrhoeae strain FA1090, which has been mapped previously, shows complex differences in their gene locations.
    Keywords: Neisseria Meningitidis -- Genetic Aspects ; Neisseria Gonorrhoeae -- Genetic Aspects
    ISSN: 0021-9193
    Source: Cengage Learning, Inc.
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  • 2
    In: Journal of Bacteriology, April, 1994, Vol.176(7-8), p.2055(6)
    Description: 28 genetic markers are used to specify positions on the chromosomal map of Neisseria gonorrhoeae FA1090. Southern blots of enzyme-digested DNA sequences analyzed by cloned gonococcal genes are used to detect gene positions in the strains. The total number of markers is 68. Genetic markers provide data about gene regulation and chromosome arrangement.
    Keywords: Neisseria Gonorrhoeae -- Genetic Aspects ; Genetic Markers -- Analysis
    ISSN: 0021-9193
    E-ISSN: 10985530
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  • 3
    Language: English
    In: The Journal of Infectious Diseases, 03/1999, Vol.179(s2), pp.S375-S379
    Description: Infection with Neisseria gonorrhoeae has adverse consequences for reproductive health and facilitates the transmission of the human immunodeficiency virus. A major limitation in the development of gonococcal vaccines has been the lack of an animal model. Urethral infection can be initiated in male volunteer subjects through urethral inoculation. Several hundred patients have participated in studies using this experimental infection model. These studies have helped define the natural history of experimental infection and provided a better understanding of phenotypic and genotypic variation of gonococci in vivo. Isogenic molecular mutants can be used to define a role for gonococcal surface structures, including pilin and transferrin-binding proteins; recent results demonstrate that gonococci unable to express transferrin- and lactoferrin-binding proteins cannot cause urethral infection. The experimental model has proven to be an efficient means of studying gonococcal infection and focusing vaccine development. In addition, this model should allow vaccines to be tested quickly and efficiently.
    Keywords: Medicine ; Biology;
    ISSN: 0022-1899
    E-ISSN: 1537-6613
    Source: CrossRef
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  • 4
    Language: English
    In: The Journal of Infectious Diseases, 1 March 1999, Vol.179, pp.S375-S379
    Description: Infection with Neisseria gonorrhoeae has adverse consequences for reproductive health and facilitates the transmission of the human immunodeficiency virus. A major limitation in the development of gonococcal vaccines has been the lack of an animal model. Urethral infection can be initiated in male volunteer subjects through urethral inoculation. Several hundred patients have participated in studies using this experimental infection model. These studies have helped define the natural history of experimental infection and provided a better understanding of phenotypic and genotypic variation of gonococci in vivo. Isogenic molecular mutants can be used to define a role for gonococcal surface structures, including pilin and transferrin-binding proteins; recent results demonstrate that gonococci unable to express transferrin- and lactoferrin-binding proteins cannot cause urethral infection. The experimental model has proven to be an efficient means of studying gonococcal infection and focusing vaccine development. In addition, this model should allow vaccines to be tested quickly and efficiently.
    Keywords: Health sciences -- Medical conditions -- Infections -- Neisseria gonorrhoeae ; Health sciences -- Medical treatment -- Biological therapy -- Neisseria gonorrhoeae ; Physical sciences -- Chemistry -- Chemical compounds -- Neisseria gonorrhoeae ; Biological sciences -- Biology -- Microbiology -- Neisseria gonorrhoeae ; Health sciences -- Medical conditions -- Infections -- Neisseria gonorrhoeae ; Health sciences -- Medical conditions -- Infections -- Neisseria gonorrhoeae ; Applied sciences -- Research methods -- Modeling -- Neisseria gonorrhoeae ; Behavioral sciences -- Human behavior -- Social behavior -- Neisseria gonorrhoeae ; Health sciences -- Medical sciences -- Immunology -- Neisseria gonorrhoeae ; Biological sciences -- Biology -- Genetics -- Neisseria gonorrhoeae
    ISSN: 00221899
    Source: Archival Journals (JSTOR)
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  • 5
    Language: English
    In: The Journal of Infectious Diseases, 1 March 1999, Vol.179, pp.S375-S379
    Description: Infection with Neisseria gonorrhoeae has adverse consequences for reproductive health and facilitates the transmission of the human immunodeficiency virus. A major limitation in the development of gonococcal vaccines has been the lack of an animal model. Urethral infection can be initiated in male volunteer subjects through urethral inoculation. Several hundred patients have participated in studies using this experimental infection model. These studies have helped define the natural history of experimental infection and provided a better understanding of phenotypic and genotypic variation of gonococci in vivo. Isogenic molecular mutants can be used to define a role for gonococcal surface structures, including pilin and transferrin-binding proteins; recent results demonstrate that gonococci unable to express transferrin- and lactoferrin-binding proteins cannot cause urethral infection. The experimental model has proven to be an efficient means of studying gonococcal infection and focusing vaccine development. In addition, this model should allow vaccines to be tested quickly and efficiently.
    Keywords: Health sciences -- Medical conditions -- Infections -- Neisseria gonorrhoeae ; Health sciences -- Medical treatment -- Biological therapy -- Neisseria gonorrhoeae ; Physical sciences -- Chemistry -- Chemical compounds -- Neisseria gonorrhoeae ; Biological sciences -- Biology -- Microbiology -- Neisseria gonorrhoeae ; Health sciences -- Medical conditions -- Infections -- Neisseria gonorrhoeae ; Health sciences -- Medical conditions -- Infections -- Neisseria gonorrhoeae ; Applied sciences -- Research methods -- Modeling -- Neisseria gonorrhoeae ; Behavioral sciences -- Human behavior -- Social behavior -- Neisseria gonorrhoeae ; Health sciences -- Medical sciences -- Immunology -- Neisseria gonorrhoeae ; Biological sciences -- Biology -- Genetics -- Neisseria gonorrhoeae
    ISSN: 00221899
    Source: Archival Journals (JSTOR)
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  • 6
    In: Journal of Bacteriology, June, 1994, Vol.176(11-12), p.3397(3)
    Description: Mature moieties of maltose-binding protein (MBP) have an active role in export in E. coli. Thirty three amino acids of the mature moiety of MBP initiate export and orient the signal peptide with regard to the membrane and interact with the secretion-machinery, including signal peptidase I. MBP is translocated across the cytoplasmic membrane of E. coli aided by the 33 amino acids which inhibit processing of ribose binding protein.
    Keywords: Escherichia Coli -- Genetic Aspects ; Transport Proteins -- Analysis ; Amino Acid Sequencing -- Analysis
    ISSN: 0021-9193
    E-ISSN: 10985530
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  • 7
    In: Journal of Bacteriology, Nov, 1993, Vol.175(21-22), p.6988(8)
    Description: The export of maltose-binding protein (MBP) in Escherichia coli is dependent on chaperone SecB, whereas export of ribose-binding protein (RBP) is independent of SecB. The sites of MBP involved in the interaction with SecB are determined by constructing hybrids between MBP and RBP in SecB mutant cells.
    Keywords: Transport Proteins -- Analysis ; Escherichia Coli -- Research
    ISSN: 0021-9193
    E-ISSN: 10985530
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  • 8
    In: Infection and Immunity, 1999, Vol. 67(6), p.3009
    Description: Many mucosal pathogens, including Neisseria gonorrhoeae, produce proteases that cleave immunoglobulin A (IgA), the predominant immunoglobulin class produced at mucosal surfaces. While considerable circumstantial evidence suggests that IgA1 protease contributes to gonococcal virulence, there is no direct evidence that N. gonorrhoeae requires IgA1 protease activity to infect a human host. We constructed a N. gonorrhoeae iga mutant without introducing new antibiotic resistance markers into the final mutant strain and used human experimental infection to test the ability of the mutant to colonize the male urethra and to cause gonococcal urethritis. Four of the five male volunteers inoculated with the Iga super(-) mutant became infected. In every respect--clinical signs and symptoms, incubation period between inoculation and infection, and the proportion of volunteers infected--the outcome of human experimental infection with FA1090iga was indistinguishable from that previously reported for a variant of parent strain FA1090 matching the mutant in expression of Opa proteins, lipooligosaccharide, and pilin. These results indicate that N. gonorrhoeae does not require IgA1 protease production to cause experimental urethritis in males.
    Keywords: Neisseria Gonorrhoeae ; Proteinase ; Immunoglobulins ; Urethra ; Genitourinary Tract Diseases ; Mutants ; Enzymes;
    ISSN: 0019-9567
    ISSN: 00199567
    E-ISSN: 10985522
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  • 9
    Language: English
    In: The Journal of Infectious Diseases, 1 April 1985, Vol.151(4), pp.650-657
    Description: Antigenic diversity among and within strains of Neisseria gonorrhoeae and Neisseria meningitidis has complicated studies of the pathogenesis of these strains and obstructed vaccine development. We previously described a distinct surface antigen (H.8) common to pathogenic Neisseria. We have now demonstrated in vivo expression of the H.8 antigen by detecting antibody responses to the antigen in 13 patients with disseminated neisserial infections. Each serum sample from a convalescent patient blocked the binding between the infecting meningococcal or gonococcal strain and a monoclonal antibody directed to the H.8 antigen, as demonstrated by binding-inhibition studies in enzyme-linked immunosorbent assays (P 〈 .005). Testing by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and western blotting demonstrated an IgG response in each convalescent serum to an antigen co-migrating with the H.8 antigen. Specificity of this antibody response was confirmed by probing recombinant bacteriophage that expressed the H.8 antigen. The commonality and the immunogenicity of the H.8 antigen indicate its possible role in the pathogenesis of, and its potential as a vaccine component for, gonococcal and meningococcal diseases.
    Keywords: Health sciences -- Medical sciences -- Immunology -- Monoclonal antibodies ; Biological sciences -- Biology -- Microbiology -- Neisseria gonorrhoeae ; Health sciences -- Medical sciences -- Immunology -- Neisseria meningitidis ; Health sciences -- Medical sciences -- Immunology -- Neisseria meningitidis ; Health sciences -- Medical conditions -- Infections -- Neisseria meningitidis ; Biological sciences -- Biology -- Microbiology -- Neisseria meningitidis ; Biological sciences -- Biology -- Microbiology -- Neisseria meningitidis ; Biological sciences -- Biology -- Microbiology -- Neisseria meningitidis ; Health sciences -- Medical sciences -- Immunology -- Neisseria meningitidis ; Physical sciences -- Physics -- Microphysics -- Neisseria meningitidis
    ISSN: 00221899
    E-ISSN: 15376613
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  • 10
    Language: English
    In: The Journal of Infectious Diseases, 1 February 1986, Vol.153(2), pp.196-201
    Description: Cette étude analyse successivement les variations des pili, la variation d'une protéine (RII) de la membrane externe et les implications cliniques.
    Keywords: Physical sciences -- Chemistry -- Chemical compounds -- Neisseria gonorrhoeae ; Biological sciences -- Biology -- Genetics -- Neisseria gonorrhoeae ; Biological sciences -- Biology -- Genetics -- Neisseria gonorrhoeae ; Biological sciences -- Biology -- Genetics -- Neisseria gonorrhoeae ; Biological sciences -- Biology -- Microbiology -- Neisseria gonorrhoeae ; Physical sciences -- Chemistry -- Chemical compounds -- Neisseria gonorrhoeae ; Biological sciences -- Biology -- Genetics -- Neisseria gonorrhoeae ; Biological sciences -- Biology -- Cytology -- Neisseria gonorrhoeae ; Physical sciences -- Chemistry -- Chemical compounds -- Neisseria gonorrhoeae ; Biological sciences -- Biology -- Genetics -- Neisseria gonorrhoeae
    ISSN: 00221899
    E-ISSN: 15376613
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