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  • 1
    Language: German
    In: Aktuelle Urologie, July 2013, Vol.44(4), pp.260-1
    Keywords: Cystectomy ; Postoperative Complications -- Epidemiology ; Robotics -- Methods ; Urinary Bladder Neoplasms -- Surgery ; Urinary Diversion -- Methods
    ISSN: 00017868
    E-ISSN: 1438-8820
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  • 2
    Language: English
    In: The Journal of Urology, April 2015, Vol.193(4), pp.e726-e726
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.juro.2015.02.2152 Byline: Atiqullah Aziz, Michael Rink, Marianne Schmid, Felix Chun, Roland Dahlem Author Affiliation: Hamburg, Germany Article Note: (footnote) Source of Funding: none
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
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  • 3
    Language: English
    In: The Journal of Urology, April 2017, Vol.197(4), pp.996-997
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
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  • 4
    Language: English
    In: The Journal of Urology, 2017, Vol.197(4), p.996(2)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.juro.2016.10.129 Byline: Philipp Gild, Felix K.H. Chun, Andreas Becker Author Affiliation: Center for Surgery and Public Health and Division of Urology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
    ISSN: 0022-5347
    Source: Cengage Learning, Inc.
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  • 5
    Language: English
    In: The Journal of Urology, April 2016, Vol.195(4), pp.e898-e899
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.juro.2016.02.1381 Byline: Philipp Mandel, Felix Chun, Markus Graefen, Hartwig Huland, Derya Tilki Author Affiliation: Hamburg, Germany Article Note: (footnote) Source of Funding: None
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
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  • 6
    Language: English
    In: The Journal of Urology, April 2016, Vol.195(4), pp.e1050-e1050
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.juro.2016.02.2049 Byline: Philipp Mandel, Markus Graefen, Felix Chun, Hartwig Huland, Derya Tilki Author Affiliation: Hamburg, Germany Article Note: (footnote) Source of Funding: None
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
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  • 7
    Language: German
    In: Aktuelle Urologie, September 2014, Vol.45(5), pp.348-9
    Description: Besonders im Kindesalter ergeben sich bei Verdacht auf eine Harnwegsinfektion immer wieder folgende Fragen: Was ist die richtige Art der Uringewinnung? Ist eine bakteriologische Urindiagnostik immer notwendig? Wann kommt eine weiterführende bildgebende Diagnostik zum Einsatz? Und wie sieht die diagnostische Strategie nach Pyelonephritis aus?
    Keywords: Medicine & Public Health ; Urology ; Medicine;
    ISSN: 14329026
    E-ISSN: 1438-8820
    E-ISSN: 21965676
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  • 8
    Language: English
    In: The Journal of Urology, May 2012, Vol.187(5), pp.1608-1613
    Description: The longer operative time of holmium laser enucleation of the prostate compared to transurethral resection of the prostate or simple open prostatectomy reported in the literature might have been biased by the unavailability of a soft tissue morcellator, limited surgical experience with holmium laser prostate enucleation or the fact that significantly more tissue was removed by enucleation than by resection. We objectively compared the resection speed of contemporary holmium laser enucleation vs transurethral resection of the prostate and of holmium laser enucleation vs simple open prostatectomy. The study cohort consisted of 100 cases of transurethral prostate resection and 60 of simple open prostatectomy from our previous randomized, controlled trials. These cases were subjected to matched pair analysis with greater than 1,000 from our prospective contemporary database on holmium laser prostate enucleation. Exact matches were made for the same amount of resected tissue. In all contemporary holmium laser enucleation cases a mechanical soft tissue morcellator was used. We calculated and compared the specific resection speed in gm per minute and operative time for the same amount of resected tissue. In groups 1 and 2 we matched 99 exact laser enucleation-transurethral resection pairs and 53 exact laser enucleation-simple open prostatectomy pairs, respectively. Resection speed and operative time for laser enucleation were statistically significantly faster than for resection (0.61 vs 0.51 gm per minute and 62 vs 73 minutes, p 〈0.01) and similar to those of simple open prostatectomy (0.92 vs 1.0 gm per minute and 101 vs 90 minutes, respectively, p ≥0.21). Resection speed seems to be an objective criterion for comparing the efficacy of prostatic tissue removal. Based on resection speed holmium laser enucleation of the prostate is faster than transurethral resection of the prostate and similar to simple open prostatectomy.
    Keywords: Prostate ; Prostatectomy ; Transurethral Resection of Prostate ; Laser Therapy ; Prostatic Hyperplasia ; Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
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  • 9
    In: BJU International, December 2012, Vol.110(11b), pp.E771-E777
    Description: Byline: Jens Bedke, Felix K.-H. Chun, Axel Merseburger, Marcus Scharpf, Kathrin Kasprzyk, David Schilling, Karl-Dietrich Sievert, Arnulf Stenzl, Stephan Kruck Keywords: renal cell cancer; systemic inflammation; biomarkers; CRP; WBC; threshold; predictive accuracy What's known on the subject? and What does the study add? White blood cell count and C-reactive protein are reliable prognostic RCC Biomarkers.Nevertheless, accepted cut-offs for risk stratifications are missing. Therefore, both parameters were re-evaluated and multivariable analyses revealed an optimal CRP breakpoint at 0.25mg/dL to be best to stratify patients at risk of cancer-specific mortality. However, this CRP-based prediction added no additional information compared to a clinico-pathological based model. Objective To re-evaluate the prognostic and predictive significance of the preoperative white blood cell (WBC) count and C-reactive protein (CRP) that independently predicts patient prognosis and to determine optimal threshold values for CRP. Patients and Methods From 1996 to 2005, 327 patients with surgery for clear cell renal cell carcinoma were retrospectively evaluated. Cox proportional hazard models were used, adjusted for the effects of tumour stage, size, Fuhrman grade and Karnofsky index, to evaluate the prognostic significance of WBC count and CRP and to identify threshold values. Identified thresholds were correlated with clinicopathological parameters and used to estimate cancer-specific survival. To prove any additional predictive accuracy of the identified threshold it was compared with a clinicopathological base model using the Harrell concordance index (c-index). Results In univariable analyses WBC count was a significant prognostic marker at a concentration of 9.5/I1/4L (hazard ratio [HR] 1.83) and 11.0/I1/4L (HR 2.09) and supported CRP values of 0.25mg/dL (HR 6.47, P 0.001) and 0.5mg/dL (HR 7.15, P 0.001) as potential threshold values. If adjusted by the multivariable models WBC count showed no clear breakpoint, but a CRP value of 0.25mg/dL (HR 2.80, P = 0.027) proved to be optimal. Reduced cancer-specific survival was proved for CRP 0.25mg/dL (median 69.9 vs 92.3 months). Median follow-up was 57.5 months with 72 (22%) tumour-related deaths. The final model built by the addition of CRP 0.25mg/dL did not improve predictive accuracy (c-index 0.877) compared with the clinicopathological base model (c-index 0.881) which included TNM stage, grading and Karnofsky index. Conclusions Multivariable analyses revealed that an optimal breakpoint of CRP at a value of 0.25mg/dL was best to stratify patients at risk of cancer-specific mortality, but CRP 0.25mg/dL added no additional information in the prediction model. Therefore we cannot recommend measuring CRP as the traditional parameters of TNM stage, grading and Karnofsky index are already of high predictive accuracy. CAPTION(S): Supporting info item Testosterone levels and percentage of biopsy affected by tumour. Linear regression between the variables testosterone and percentage of tumour representation in the biopsy sample is displayed (P 0.01). In our centre, the tumour burden in the biopsy is expressed as the percentage of tumour in each prostatic lobe, ranging from 〉0% to 100%. Thus, the percentage of tumour represented in the biopsy adding the two prostatic lobes ranges from 〉0% to 200%. Testosterone levels and progression risk. Tumours were subclassified depending on their D'Amico risk of progression: low risk, PSA 10, DRE [less than or equal to] T2a and Gleason score [less than or equal to]6; intermediate risk, PSA 10-20, DRE = T2b and Gleason score 7; high risk, PSA 〉 20 or DRE a[yen] T2c or Gleason score a[yen]8. Low risk, testosterone 470 [+ or -] 171 ng/dL; intermediate risk, testosterone 445 [+ or -] 151 ng/dL; high risk, testosterone 365 [+ or -] 162 ng/dL; P= 0.03. Supporting info item
    Keywords: Renal Cell Cancer ; Systemic Inflammation ; Biomarkers ; Crp ; Wbc ; Threshold ; Predictive Accuracy
    ISSN: 1464-4096
    E-ISSN: 1464-410X
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  • 10
    Language: English
    In: The Journal of Urology, April 2017, Vol.197(4), pp.e988-e988
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.juro.2017.02.2212 Byline: Raisa Sinaida Pompe, Philipp Gild, Felix K. Chun Author Affiliation: Hamburg, Germany Article Note: (footnote) Source of Funding: none
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
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