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Berlin Brandenburg

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  • 1
    In: Journal of Virology and Emerging Diseases ( ISSN 2471-822X ), 2016, Vol.1(2)
    ISSN: Journal of Virology and Emerging Diseases ( ISSN 2471-822X )
    E-ISSN: 2471822X
    Source: CrossRef
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  • 2
    Language: English
    In: European Journal of Cancer, December 2016, Vol.69, pp.S53-S53
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0959-8049(16)32745-9 Byline: M. Michaelis, M. Wass, J. Cinatl
    Keywords: Medicine
    ISSN: 0959-8049
    E-ISSN: 1879-0852
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  • 3
    Language: English
    In: European Journal of Cancer, December 2016, Vol.69, pp.S72-S72
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0959-8049(16)32806-4 Byline: M. Michaelis, M. Wass, J. Cinatl
    Keywords: Medicine
    ISSN: 0959-8049
    E-ISSN: 1879-0852
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  • 4
    Language: English
    In: European Journal of Cancer, July 2016, Vol.61, pp.S120-S120
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0959-8049(16)61426-0 Byline: M. Michaelis, M. Wass, J. Cinatl
    Keywords: Medicine
    ISSN: 0959-8049
    E-ISSN: 1879-0852
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  • 5
    In: Oncogene, 2013
    Description: Chemotherapy is the most common treatment for cancer. However, multidrug resistance (MDR) remains a major obstacle to effective chemotherapy, limiting the efficacy of both conventional chemotherapeutic and novel biologic agents. The constitutive androstane receptor (CAR), a xenosensor, is a key regulator of MDR. It functions in xenobiotic detoxification by regulating the expression of phase I drug-metabolizing enzymes and ATP-binding cassette (ABC) transporters, whose overexpression in cancers and whose role in drug resistance make them potential therapeutic targets for reducing MDR. MicroRNAs (miRNAs) are endogenous negative regulators of gene expression and have been implicated in most cellular processes, including drug resistance. Here, we report the inversely related expression of miR-137 and CAR in parental and doxorubicin-resistant neuroblastoma cells, wherein miR-137 is downregulated in resistant cells. miR-137 overexpression resulted in downregulation of CAR protein and mRNA (via mRNA degradation);it sensitized doxorubicin- resistant cells to doxorubicin (as shown by reduced proliferation, increased apoptosis and increased G2-phase cell cycle arrest) and reduced the in vivo growth rate of neuroblastoma xenografts. We observed similar results in cellular models of hepatocellular and colon cancers, indicating that the doxorubicin-sensitizing effect of miR-137 is not tumor type-specific. Finally, we show for the first time a negative feedback loop whereby miR-137 downregulates CAR expression and CAR downregulates miR-137 expression. Hypermethylation of the miR-137 promoter and negative regulation of miR-137 by CAR contribute in part to reduced miR-137 expression and increased CAR and MDR1 expression in doxorubicin-resistant neuroblastoma cells. These findings demonstrate that miR-137 is a crucial regulator of cancer response to doxorubicin treatment, and they identify miR-137 as a highly promising target to reduce CAR-driven doxorubicin resistance. Oncogene (2014) 33, 3717-3729; doi:10.1038/onc.2013.330; published online 12 August 2013 Keywords: microRNA; constitutive androstane receptor; miR-137; MDR1; doxorubicin
    Keywords: Drug Resistance -- Genetic Aspects ; Neuroblastoma -- Genetic Aspects ; Neuroblastoma -- Drug Therapy ; Microrna -- Health Aspects ; Doxorubicin -- Dosage And Administration ; Doxorubicin -- Genetic Aspects ; Cell Receptors -- Genetic Aspects ; Cell Receptors -- Health Aspects ; Genetic Regulation -- Research ; Genetic Research;
    ISSN: 0950-9232
    E-ISSN: 14765594
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  • 6
    Language: English
    In: European Journal of Cancer, December 2016, Vol.69, pp.S72-S72
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0959-8049(16)32805-2 Byline: M. Michaelis, F. Rothweiler, N. Loeschmann, M. Sharifi, T. Ghafourian, J. Cinatl
    Keywords: Medicine
    ISSN: 0959-8049
    E-ISSN: 1879-0852
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  • 7
    Language: English
    In: Medical Microbiology and Immunology, 2012, Vol.201(1), pp.1-5
    Description: A look back is done to some clinical and basic research activities recently published in medical microbiology and immunology. The review covers clinical experiences and in vitro experiments to understand the emergency, pathogenicity, epidemic spread, and vaccine-based prevention of avian and swine-origin flu. Some new developments and concepts in diagnosis, (molecular) epidemiology, and therapy of AIDS, viral hepatitis C, and herpesvirus-associated diseases are outlined. Regulation of immune system has been discussed in a special issue 2010 including some aspects of CNS affections (measles). Mycobacterial infection and its prevention by modern recombinant vaccines have reached new interest, as well as new concepts of vaccination and prophylaxis against several other bacteria. Adaptation to host niches enables immune escape (example brucella) and determines virulence (example N. meningitidis). Chlamydia pneumoniae, previously considered to trigger atherosclerosis, is hypothetically associated to Alzheimer disease, while CMV, another putative trigger of atherosclerosis, gains evidence of oncomodulation in CNS tumor diseases. In terms of globalization, exotic virus infections are increasingly imported from southern countries.
    Keywords: Influenza ; AIDS ; Viral hepatitis ; Herpesviruses ; Tuberculosis ; Pathogen variation ; Immune response
    ISSN: 0300-8584
    E-ISSN: 1432-1831
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  • 8
    Language: English
    In: European Journal of Cancer, December 2016, Vol.69, pp.S47-S47
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0959-8049(16)32725-3 Byline: M. Michaelis, B. Agha, F. Rothweiler, N. Loeschmann, Y. Voges, F. Westermann, M. Wass, J. Cinatl
    Keywords: Medicine
    ISSN: 0959-8049
    E-ISSN: 1879-0852
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  • 9
    Language: English
    In: European Journal of Cancer, July 2016, Vol.61, pp.S120-S121
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0959-8049(16)61427-2 Byline: M. Michaelis, F. Rothweiler, N. Loschmann, M. Sharifi, T. Ghafourian, J. Cinatl
    Keywords: Medicine
    ISSN: 0959-8049
    E-ISSN: 1879-0852
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  • 10
    Language: English
    In: European Journal of Cancer, July 2016, Vol.61, pp.S120-S120
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0959-8049(16)61424-7 Byline: M. Michaelis, B. Agha, R. Florian, N. Loschmann, Y. Voges, F. Westermann, M. Wass, J. Cinatl
    Keywords: Medicine
    ISSN: 0959-8049
    E-ISSN: 1879-0852
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